Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Geracimos Rassias"'
Autor:
Geracimos Rassias, Neil R. Curtis, John M. Northall, Matthew Gray, Neil G. Stevenson, Andrew J. Walker, Jeremy C. Prodger
Publikováno v:
Organic Process Research & Development. 14:92-98
The supply route to GlaxoSmithKline’s 5HT4 receptor agonist 1 centred on the construction of key benzopyran fragment 2. Our attempts to define the final manufacturing route for this component are described through a series of disconnections. The sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::742ea08d1ff05825c70919217da5f4a2
https://doi.org/10.1021/op900188v
https://doi.org/10.1021/op900188v
Publikováno v:
Tetrahedron Letters. 50:5565-5568
Our synthetic efforts towards an iNOS (inducible isoform of the nitric oxide synthase) inhibitor led us to the relatively unexplored field of generating and controlling the reactivity of chiral, unsymmetrical thiiranium species. We found that product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e151cbd2a96b44ee25c4d2a460d618ab
https://doi.org/10.1016/j.tetlet.2009.07.059
https://doi.org/10.1016/j.tetlet.2009.07.059
Autor:
Gary T. Borrett, Graham R. Slater, Stephen A. Hermitage, Ian P. Andrews, Peter M. Kincey, Smith Neil, Mahesh J. Sanganee, Geracimos Rassias
Publikováno v:
Organic Process Research & Development. 13:774-780
The original medicinal chemistry synthesis of an iNOS inhibitor presented several challenges that had to be overcome in order to constitute a supply route suitable for operation on a multikilo scal...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d72df24bc2bd3724f8c202662671f764
https://doi.org/10.1021/op900108b
https://doi.org/10.1021/op900108b
Publikováno v:
Tetrahedron Letters. 49:6279-6281
A high yielding and selective method for producing methyl 5-amino-2H-1-benzopyran-8-carboxylate derivatives via gold(I)-catalysed intramolecular alkyne hydroarylation has been developed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82cc6e88e13b647ded1c78b1860cdda2
https://doi.org/10.1016/j.tetlet.2008.08.022
https://doi.org/10.1016/j.tetlet.2008.08.022
Autor:
David P. Day, Alexandra M. Z. Slawin, Phillip Parker, Yohan Chan, André Pinto, Philip C. Bulman Page, Steven M. Allin, Christopher J. Bartlett, Geracimos Rassias, Jérôme Lacour, Benjamin R. Buckley
Publikováno v:
Journal of Organic Chemistry, Vol. 77, No 14 (2012) pp. 6128-6138
J. Org. Chem.
J. Org. Chem.
Introduction of a pseudoaxial substituent at a stereogenic center adjacent to the nitrogen atom in binaphthyl- and biphenyl-derived azepinium salt organocatalysts affords improved enantioselectivities and yields in the epoxidation of unfunctionalized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca909d9099136253b90c98594cfd6816
https://pubmed.ncbi.nlm.nih.gov/22708806
https://pubmed.ncbi.nlm.nih.gov/22708806