Sputum and blood transcriptomics characterisation of the inhaled PDE4 inhibitor CHF6001 on top of triple therapy in patients with chronic bronchitis

Autor: Mirco Govoni, Michele Bassi, Stefano Vezzoli, Germano Lucci, Aida Emirova, Marie Anna Nandeuil, Stefano Petruzzelli, Gera L. Jellema, Ebenezer K. Afolabi, Brendan Colgan, Brian Leaker, Oliver Kornmann, Kai Michael Beeh, Henrik Watz, Dave Singh

Publikováno v: Respiratory Research, Vol 21, Iss 1, Pp 1-11 (2020)

Abstract Background Although phosphodiesterase-4 (PDE4) inhibitors have been shown to reduce COPD exacerbation rate, their biological mechanism of action is not completely elucidated at the molecular level. We aimed to characterise the whole genome g

Externí odkaz: https://doaj.org/article/329954abcd014a2482d1ae81f7bede63

Gene expression profiling during intensive cardiovascular lifestyle modification: Relationships with vascular function and weight loss

Autor: Heather L. Blackburn, Seóna McErlean, Gera L. Jellema, Ryan van Laar, Marina N. Vernalis, Darrell L. Ellsworth

Publikováno v: Genomics Data, Vol 4, Iss C, Pp 50-53 (2015)

Heart disease and related sequelae are a leading cause of death and healthcare expenditure throughout the world. Although many patients opt for surgical interventions, lifestyle modification programs focusing on nutrition and exercise have shown subs

Externí odkaz: https://doaj.org/article/27808d9fd81b4ec0aa9363b2c1bd0064

A Novel Processing-Free Method for RNAseq Analysis of Spontaneous Sputum in Chronic Obstructive Pulmonary Disease

Autor: Michele Bassi, Francesca Ricci, Mirco Govoni, Cathy M. McGeough, Gera L. Jellema

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology

Background: Assessments of airways inflammation in patients with chronic obstructive pulmonary disease (COPD) require semi-invasive procedures and specialized sample processing know-how. In this study we aimed to set up and validate a novel non-invas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d29b24ad2e556cc15a3af4b29cc8db
https://www.frontiersin.org/articles/10.3389/fphar.2021.704969/full

Sputum and blood transcriptomics characterisation of the inhaled PDE4 inhibitor CHF6001 on top of triple therapy in patients with chronic bronchitis

Autor: Brendan Colgan, Michele Bassi, Stefano Vezzoli, Mirco Govoni, Germano Lucci, Oliver Kornmann, Ebenezer K. Afolabi, Aida Emirova, Gera L. Jellema, Kai Michael Beeh, Dave Singh, Marie Anna Nandeuil, Brian Leaker, Stefano Petruzzelli, Henrik Watz

Publikováno v: Respiratory Research
Respiratory Research, Vol 21, Iss 1, Pp 1-11 (2020)

Background Although phosphodiesterase-4 (PDE4) inhibitors have been shown to reduce COPD exacerbation rate, their biological mechanism of action is not completely elucidated at the molecular level. We aimed to characterise the whole genome gene expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152ce93e30a4349557d5903e780fb460
https://pubmed.ncbi.nlm.nih.gov/32197620

Molecular subgroup of primary prostate cancer presenting with metastatic biology

Autor: Elaine W. Kay, Noel W. Clarke, Andrena McCavigan, Christopher S. Foster, Simon S. McDade, Christopher G. Eden, Gemma E Logan, D. Paul Harkin, Steven Walker, Catherine Davidson, David E. Neal, David Waugh, Bethanie Price, Christopher Steele, Jaine K. Blayney, Amir Sherif, Hardev Pandha, Richard D. Kennedy, Gera L. Jellema, Anne Y. Warren, Viktor Berge, Ian G. Mills, R. William G. Watson, Malcolm David Mason, Aud Svindland, Adam Uprichard, Laura A. Knight

Publikováno v: Walker, S M, Knight, L A, McCavigan, A M, Logan, G E, Berge, V, Sherif, A, Pandha, H, Warren, A Y, Davidson, C, Uprichard, A, Blayney, J K, Price, B, Jellema, G L, Steele, C J, Svindland, A, McDade, S S, Eden, C G, Foster, C, Mills, I G, Neal, D E, Mason, M D, W Kay, E, Waugh, D J, Harkin, D P, Watson, R W, Clarke, N W & Kennedy, R D 2017, ' Molecular Subgroup of Primary Prostate Cancer Presenting with Metastatic Biology ', European Urology, vol. 72, no. 4, pp. 509 . https://doi.org/10.1016/j.eururo.2017.03.027

Background: Approximately 4-25% of patients with early prostate cancer develop disease recurrence following radical prostatectomy.Objective: To identify a molecular subgroup of prostate cancers with metastatic potential at presentation resulting in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca15b5a77554b9ed3f4dbb9b63c5cf9
http://ora.ox.ac.uk/objects/uuid: