Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ger T. Molenaar"'
Autor:
Perry S. Kruijer, Adriaan A. Lammertsma, Danielle J. Vugts, Albert D. Windhorst, Bieneke Janssen, Uta Funke, Ger T. Molenaar, Bart N.M. van Berckel
Publikováno v:
Janssen, B, Vugts, D J, Funke, U, Molenaar, G T, Kruijer, P S, van Berckel, B N M, Lammertsma, A A & Windhorst, A D 2016, ' Imaging of neuroinflammation in Alzheimer's disease, multiple sclerosis and stroke: Recent developments in positron emission tomography ', Biochimica et Biophysica Acta. Molecular Basis of Disease, vol. 1862, no. 3, pp. 425-441 . https://doi.org/10.1016/j.bbadis.2015.11.011
Biochimica et Biophysica Acta. Molecular Basis of Disease, 1862(3), 425-441. Elsevier
Biochimica et Biophysica Acta. Molecular Basis of Disease, 1862(3), 425-441. Elsevier
Neuroinflammation is thought to play a pivotal role in many diseases affecting the brain, including Alzheimer's disease, multiple sclerosis and stroke. Neuroinflammation is characterised predominantly by microglial activation, which can be visualised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3350e029d36c9e5805bcc3c6b0eadb80
Autor:
Jeroen J.M. Hoozemans, Rostislav V Shevchenko, Ger T. Molenaar, Veerle Baekelandt, Sylvie Chalon, Aurélie Doméné, Guy Bormans, Adriana Maggi, Wissam Beaino, Michael Kassiou, Adriaan A. Lammertsma, Uta Funke, Shane M. Wilkinson, Robert C. Schuit, Alessandro Villa, Esther J.M. Kooijman, Johan van den Hoek, Bieneke Janssen, Anke Van der Perren, Mansoor Chishty, Danielle J. Vugts, Albert D. Windhorst, Dieter Ory
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Janssen, B, Vugts, D J, Wilkinson, S M, Ory, D, Chalon, S, Hoozemans, J J M, Schuit, R C, Beaino, W, Kooijman, E J M, Van Den Hoek, J, Chishty, M, Doméné, A, Van Der Perren, A, Villa, A, Maggi, A, Molenaar, G T, Funke, U, Shevchenko, R V, Baekelandt, V, Bormans, G, Lammertsma, A A, Kassiou, M & Windhorst, A D 2018, ' Identification of the allosteric P2X 7 receptor antagonist [ 11 C]SMW139 as a PET tracer of microglial activation ', Scientific Reports, vol. 8, no. 1, 6580 . https://doi.org/10.1038/s41598-018-24814-0
Scientific Reports, 8(1):6580. Nature Publishing Group
Janssen, B, Vugts, D J, Wilkinson, S M, Ory, D, Chalon, S, Hoozemans, J J M, Schuit, R C, Beaino, W, Kooijman, E J M, Van Den Hoek, J, Chishty, M, Doméné, A, Van Der Perren, A, Villa, A, Maggi, A, Molenaar, G T, Funke, U, Shevchenko, R V, Baekelandt, V, Bormans, G, Lammertsma, A A, Kassiou, M & Windhorst, A D 2018, ' Identification of the allosteric P2X 7 receptor antagonist [ 11 C]SMW139 as a PET tracer of microglial activation ', Scientific Reports, vol. 8, no. 1, 6580 . https://doi.org/10.1038/s41598-018-24814-0
Scientific Reports, 8(1):6580. Nature Publishing Group
The P2X7 receptor plays a significant role in microglial activation, and as a potential drug target, the P2X7 receptor is also an interesting target in positron emission tomography. The current study aimed at the development and evaluation of a poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09cc71df25ad681f797af725ffc97a78
https://doi.org/10.1038/s41598-018-24814-0
https://doi.org/10.1038/s41598-018-24814-0
Autor:
Bieneke, Janssen, Danielle J, Vugts, Shane M, Wilkinson, Dieter, Ory, Sylvie, Chalon, Jeroen J M, Hoozemans, Robert C, Schuit, Wissam, Beaino, Esther J M, Kooijman, Johan, van den Hoek, Mansoor, Chishty, Aurélie, Doméné, Anke, Van der Perren, Alessandro, Villa, Adriana, Maggi, Ger T, Molenaar, Uta, Funke, Rostislav V, Shevchenko, Veerle, Baekelandt, Guy, Bormans, Adriaan A, Lammertsma, Michael, Kassiou, Albert D, Windhorst
Publikováno v:
Scientific Reports
The P2X7 receptor plays a significant role in microglial activation, and as a potential drug target, the P2X7 receptor is also an interesting target in positron emission tomography. The current study aimed at the development and evaluation of a poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::21b81817e8cfd68703e5cd406318447c
https://pubmed.ncbi.nlm.nih.gov/29700413
https://pubmed.ncbi.nlm.nih.gov/29700413
Publikováno v:
Synlett. 25:2221-2224
An improved solid-phase synthesis of the neuroprotective tripeptide, glycyl-prolyl-glutamic acid, bearing a hydrophobic tail to create an amphiphile is described. The new solid-phase synthesis was adapted to prepare several analogues bearing differin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0250197d7be41916aa2b3bb3e27b446d
https://doi.org/10.1055/s-0034-1378539
https://doi.org/10.1055/s-0034-1378539
Autor:
Esther Lutgens, Hein J. Verberne, Vivian de Waard, Albert D. Windhorst, Berthe L. F. van Eck-Smit, Victorine A Pinas, Jos Eersels, Jan J. Piek, Ger T. Molenaar, Nazanin Hakimzadeh, Kora de Bruin, Jan Booij
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187767 (2017)
PLoS ONE
Hakimzadeh, N, Pinas, V A, Molenaar, G, de Waard, V, Lutgens, E, van Eck-Smit, B L F, de Bruin, K, Piek, J J, Eersels, J L H, Booij, J, Verberne, H J & Windhorst, A D 2017, ' Novel molecular imaging ligands targeting matrix metalloproteinases 2 and 9 for imaging of unstable atherosclerotic plaques ', PLoS ONE, vol. 12, no. 11, pp. e0187767 . https://doi.org/10.1371/journal.pone.0187767
PLoS ONE, 12(11). Public Library of Science
PLoS ONE, 12(11):e0187767. Public Library of Science
PLoS ONE
Hakimzadeh, N, Pinas, V A, Molenaar, G, de Waard, V, Lutgens, E, van Eck-Smit, B L F, de Bruin, K, Piek, J J, Eersels, J L H, Booij, J, Verberne, H J & Windhorst, A D 2017, ' Novel molecular imaging ligands targeting matrix metalloproteinases 2 and 9 for imaging of unstable atherosclerotic plaques ', PLoS ONE, vol. 12, no. 11, pp. e0187767 . https://doi.org/10.1371/journal.pone.0187767
PLoS ONE, 12(11). Public Library of Science
PLoS ONE, 12(11):e0187767. Public Library of Science
Molecular imaging of matrix metalloproteinases (MMPs) may allow detection of atherosclerotic lesions vulnerable to rupture. In this study, we develop a novel radiolabelled compound that can target gelatinase MMP subtypes (MMP2/9) with high selectivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d81292e09ce41e7c9b6ab1ec2d763b5
https://doi.org/10.1371/journal.pone.0187767
https://doi.org/10.1371/journal.pone.0187767