Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Ger H Koek"'
Autor:
Toon J I De Munck, Markus Boesch, Pauline Verhaegh, Ad A M Masclee, Daisy Jonkers, Jos F van Pelt, Johannie du Plessis, Hannelie Korf, Frederik Nevens, Ger H Koek, Schalk Van der Merwe, Jef Verbeek
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251822 (2021)
BackgroundNeuregulin 4 (Nrg4), a novel adipokine enriched in brown adipose tissue has been observed to negatively regulate de novo hepatic lipogenesis and limit nonalcoholic fatty liver disease (NAFLD) progression to nonalcoholic steatohepatitis (NAS
Externí odkaz:
https://doaj.org/article/4fd2416859f4431aa48d925e75ea8bf8
Autor:
Romy M W Kremers, Marie-Claire Kleinegris, Marisa Ninivaggi, Bas de Laat, Hugo Ten Cate, Ger H Koek, Rob J Wagenvoord, H Coenraad Hemker
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177020 (2017)
Impaired coagulation factor synthesis in cirrhosis causes a reduction of most pro- and anticoagulant factors. Cirrhosis patients show no clear bleeding or thrombotic phenotype, although they are at risk for both types of hemostatic event. Thrombin ge
Externí odkaz:
https://doaj.org/article/1074baf786d4412cbed9327212ed6273
Autor:
Wen Liang, Aswin L Menke, Ann Driessen, Ger H Koek, Jan H Lindeman, Reinout Stoop, Louis M Havekes, Robert Kleemann, Anita M van den Hoek
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115922 (2014)
The recently developed histological scoring system for non-alcoholic fatty liver disease (NAFLD) by the NASH Clinical Research Network (NASH-CRN) has been widely used in clinical settings, but is increasingly employed in preclinical research as well.
Externí odkaz:
https://doaj.org/article/b646b4dc76244263af85254bb820701d
Autor:
Tim Hendrikx, Veerle Bieghs, Sofie M A Walenbergh, Patrick J van Gorp, Fons Verheyen, Mike L J Jeurissen, Mandy M F Steinbusch, Nathalie Vaes, Christoph J Binder, Ger H Koek, Rinke Stienstra, Mihai G Netea, Marten H Hofker, Ronit Shiri-Sverdlov
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e78792 (2013)
While non-alcoholic steatohepatitis (NASH) is characterized by hepatic steatosis combined with inflammation, the mechanisms triggering hepatic inflammation are unknown. In Ldlr(-/-) mice, we have previously shown that lysosomal cholesterol accumulati
Externí odkaz:
https://doaj.org/article/359a9c9b1316462799400f896734f03a
Autor:
Steven A L W Vanhoutvin, Freddy J Troost, Henrike M Hamer, Patrick J Lindsey, Ger H Koek, Daisy M A E Jonkers, Andrea Kodde, Koen Venema, Robert J M Brummer
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6759 (2009)
Fermentation of dietary fiber in the colon results in the production of short chain fatty acids (mainly propionate, butyrate and acetate). Butyrate modulates a wide range of processes, but its mechanism of action is mostly unknown. This study aimed t
Externí odkaz:
https://doaj.org/article/a3b54fccdb274f68b376c2b8c44b449c
Autor:
Fien de Boom, Ali Talib, Yvonne G. M. Roebroek, Givan F. Paulus, Ger H. Koek, Simon G. F. Robben, Bjorn Winkens, Nicole D. Bouvy, L. W. Ernest van Heurn
Publikováno v:
Children, Vol 11, Iss 8, p 965 (2024)
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease in adolescents with obesity. Nonetheless, the guidelines for screening and managing this disease are contradictory. The purpose of this stud
Externí odkaz:
https://doaj.org/article/5ded975011344be19efdac70d584bbdd
Autor:
Eray Yagmur, Samira Abu Jhaisha, Lukas Buendgens, Nadezhda Sapundzhieva, Jonathan F. Brozat, Philipp Hohlstein, Maike R. Pollmanns, Ger H. Koek, Ralf Weiskirchen, Christian Trautwein, Frank Tacke, Theresa H. Wirtz, Alexander Koch
Publikováno v:
Diagnostics, Vol 12, Iss 12, p 3010 (2022)
Clusterin is a multifunctional protein that is recognized to mediate cellular stress response associated with organ failure, systemic inflammation, and metabolic alterations. The aim of this study was to determine the value of clusterin as a clinical
Externí odkaz:
https://doaj.org/article/de9f32ba8e784f828c0135f697f59e33
Autor:
Joost Boeckmans, Alexandra Gatzios, Jörn M. Schattenberg, Ger H. Koek, Robim M. Rodrigues, Tamara Vanhaecke
Publikováno v:
Liver International. 43:975-988
BACKGROUND: It is unclear whether the patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 C-to-G single nucleotide polymorphism, resulting in the substitution of isoleucine to methionine at position 148 (I148M), impedes regressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f38d5c86dbf4781680aeca9c4d374d
https://doi.org/10.1111/liv.15533
https://doi.org/10.1111/liv.15533
Publikováno v:
Journal of Applied Laboratory Medicine. 7(1):259-267
Background Primary biliary cholangitis (PBC), autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC) are autoimmune liver diseases associated with distinct autoantibodies. Diagnosis is based upon clinical, serological, and histopathology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23bcf6fb475dfdd3be46df56d7f1e7c1
https://doi.org/10.1093/jalm/jfab099
https://doi.org/10.1093/jalm/jfab099
Autor:
Toon J.I. De Munck, Pauline Verhaegh, Corinne Spooren, Zlatan Mujagic, Tobias Wienhold, Daisy Jonkers, Ad A.M. Masclee, Ger H. Koek, Jef Verbeek
Publikováno v:
Digestive and Liver Disease, 614-621. Elsevier Science
STARTPAGE=614;ENDPAGE=621;ISSN=1590-8658;TITLE=Digestive and Liver Disease
STARTPAGE=614;ENDPAGE=621;ISSN=1590-8658;TITLE=Digestive and Liver Disease
BACKGROUND AND AIM: Intestinal permeability (IP) plays an important role in the pathophysiology of nonalcoholic fatty liver disease (NAFLD). We assessed site-specific (gastroduodenum, small intestine, colon and whole gut) IP in NAFLD patients and hea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902252b5a5fc662d610da109d1640496
https://cris.maastrichtuniversity.nl/en/publications/9aaa165e-fb50-4719-98cf-24eef7249edd
https://cris.maastrichtuniversity.nl/en/publications/9aaa165e-fb50-4719-98cf-24eef7249edd
