Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Georgy Koentges"'
Autor:
Mike J Downey, Danuta M Jeziorska, Sascha Ott, T Katherine Tamai, Georgy Koentges, Keith W Vance, Till Bretschneider
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e27886 (2011)
The extraction of fluorescence time course data is a major bottleneck in high-throughput live-cell microscopy. Here we present an extendible framework based on the open-source image analysis software ImageJ, which aims in particular at analyzing the
Externí odkaz:
https://doaj.org/article/986f69cff5644414add7b98f87a58b61
Publikováno v:
Proceedings of the Royal Society B: Biological Sciences
CO 2 readily combines with H 2 O to form and H + . Because an increase of only 100 nM in the concentration of H + (a decrease of 0.1 unit of pH) in blood can prove fatal, the regulated excretion of CO 2 during breathing is an essential life-preservin
Publikováno v:
Jeziorska, D M, Koentges, G & Vance, K W 2012, ' Novel cis-regulatory modules control expression of the Hairy and Enhancer of Split-1 (HES1) transcription factor in myoblasts ', The Journal of biological chemistry, vol. 287, no. 8, pp. 5687-97 . https://doi.org/10.1074/jbc.M111.286484
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Background: DNA sequences called CRMs determine the precise patterns of gene expression. Results: We identify and characterize the function of six novel hes1 CRMs. Conclusion: HES1 expression is controlled by multiple distal CRMs in addition to the k
Autor:
Keith W, Vance, Dan J, Woodcock, John E, Reid, Till, Bretschneider, Sascha, Ott, Georgy, Koentges
Publikováno v:
Genome Biology and Evolution
The process of transcription is highly stochastic leading to cell-to-cell variations and noise in gene expression levels. However, key essential genes have to be precisely expressed at the correct amount and time to ensure proper cellular development
Autor:
Per E. Ahlberg, William D. Richardson, Andrew P. McMahon, Ulla Dennehy, Palma Iannarelli, Nicoletta Kessaris, Toshiyuki Matsuoka, Georgy Koentges
Publikováno v:
Nature. 436:347-355
The neck and shoulder region of vertebrates has undergone a complex evolutionary history. In order to identify its underlying mechanisms we map the destinations of embryonic neural crest and mesodermal stem cells using novel Cre-recombinase mediated
Publikováno v:
Zoological Journal of the Linnean Society. 143:577-597
Dendrerpeton acadianum from the Westphalian A (Upper Carboniferous) of Joggins, Nova Scotia, is a phylogenetically and chronologically early temnospondyl. Its external cranial anatomy has been used previously to suggest the presence of a tympanic mem
Publikováno v:
Neuron. 38(2):161-175
The extraordinary cellular heterogeneity of the mammalian nervous system has largely hindered the molecular analysis of neuronal identity and diversity. In order to uncover mechanisms involved in neuronal differentiation and diversification, we have
Autor:
Georgy Koentges, Alex L. Kolodkin, David D. Ginty, Jean-François Cloutier, Roman J. Giger, Catherine Dulac
Publikováno v:
Neuron. 33:877-892
The mechanisms that underlie axonal pathfinding of vomeronasal neurons from the vomeronasal organ (VNO) in the periphery to select glomeruli in the accessory olfactory bulb (AOB) are not well understood. Neuropilin-2, a receptor for secreted semaphor
Publikováno v:
Development. 124:1877-1885
Neurotrophins signal through members of the trk family of tyrosine kinase receptors and are known to regulate several neuronal properties. Although initially characterized by their ability to prevent naturally occurring cell death of subsets of neuro
Autor:
Michał Komorowski, Georgy Koentges, David A. Rand, Bärbel Finkenstädt, Dan J. Woodcock, Keith W. Vance
Publikováno v:
Bioinformatics
Woodcock, D J, Vance, K W, Komorowski, M, Koentges, G, Finkenstädt, B & Rand, D A 2013, ' A hierarchical model of transcriptional dynamics allows robust estimation of transcription rates in populations of single cells with variable gene copy number ', Bioinformatics, vol. 29, no. 12, pp. 1519-25 . https://doi.org/10.1093/bioinformatics/btt201
Woodcock, D J, Vance, K W, Komorowski, M, Koentges, G, Finkenstädt, B & Rand, D A 2013, ' A hierarchical model of transcriptional dynamics allows robust estimation of transcription rates in populations of single cells with variable gene copy number ', Bioinformatics, vol. 29, no. 12, pp. 1519-25 . https://doi.org/10.1093/bioinformatics/btt201
Motivation: cis-regulatory DNA sequence elements, such as enhancers and silencers, function to control the spatial and temporal expression of their target genes. Although the overall levels of gene expression in large cell populations seem to be prec