Synthesis, biological evaluation, X-ray molecular structure and molecular docking studies of RGD mimetics containing 6-amino-2,3-dihydroisoindolin-1-one fragment as ligands of integrin αIIbβ3

Autor: Janusz Lipkowski, V. M. Kabanov, Tatyana A. Kabanova, Pavel G. Polishchuk, Tetiana M. Khristova, Victor E. Kuz’min, Georgiy V. Samoylenko, Sergei A. Andronati, Marina S. Fonari, A. A. Krysko, Victor Ch. Kravtsov, Alexandre Varnek, Olga L. Krysko

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2013, 21 (15), pp.4646-4661. ⟨10.1016/j.bmc.2013.05.019⟩

A series of novel RGD mimetics containing phthalimidine fragment was designed and synthesized. Their antiaggregative activity determined by Born’s method was shown to be due to inhibition of fibrinogen binding to αIIbβ3. Molecular docking of RGD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a0c8bc7b554bbddfcbc094bc560230
https://doi.org/10.1016/j.bmc.2013.05.019

Design, Virtual Screening, and Synthesis of Antagonists of α IIb β 3 as Antiplatelet Agents

Autor: Tatyana A. Kabanova, Tetiana M. Khristova, Georgiy V. Samoylenko, Olga L. Krysko, Sergei A. Andronati, Alexandre Varnek, V. M. Kabanov, Victor E. Kuz’min, Alexander Yu. Kornylov, Thierry Langer, Olga Klimchuk, Pavel G. Polishchuk, A. A. Krysko

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2015, 58 (19), pp.7681-7694. ⟨10.1021/acs.jmedchem.5b00865⟩

This article describes design, virtual screening, synthesis, and biological tests of novel αIIbβ3 antagonists, which inhibit platelet aggregation. Two types of αIIbβ3 antagonists were developed: those binding either closed or open form of the pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7dc92a9416499df300b22ea976f3b15
https://hal.archives-ouvertes.fr/hal-03150648

RGD mimetics containing phthalimidine fragment as novel ligands of fibrinogen receptor

Autor: Tatyana A. Kabanova, V. M. Kabanov, Alexandre Varnek, Tetiana M. Khristova, Ruslan Ya. Grygorash, Victor E. Kuz’min, A. A. Krysko, Georgiy V. Samoylenko, Pavel G. Polishchuk, Sergei A. Andronati, Olga L. Krysko

Publikováno v: Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters, 2011, 21 (19), pp.5971-5974. ⟨10.1016/j.bmcl.2011.07.063⟩

The novel RGD mimetics with phthalimidine central fragment were synthesized with the use of 4-piperidine-4-yl-butyric, 4-piperidine-4-yl-benzoic, 4-piperazine-4-yl-benzoic and 1,2,3,4-tetrahydroisoquinoline-7-carboxylic acids as surrogates of Arg mot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3a1e46969a2eb3a39ceb63c9593ed0
https://hal.archives-ouvertes.fr/hal-03143717