Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Georgirene D. Vladutiu"'
Autor:
Wilson Chen, Heather M Ochs-Balcom, Changxing Ma, Paul J Isackson, Georgirene D Vladutiu, Jasmine A Luzum
Publikováno v:
Future Cardiol
Aim: To determine the association of coenzyme Q10 (CoQ10) use with the resolution of statin-associated muscle symptoms (SAMS). Patients & methods: Retrospective analysis of a large, multicenter survey study of SAMS (total n = 511; n = 64 CoQ10 users)
Autor:
Daniel A. Perry, Georgirene D. Vladutiu, Chang-Xing Ma, Derek W. Linskey, Paul J. Isackson, Heather M. Ochs-Balcom, Joseph D. English, Jasmine A. Luzum
Publikováno v:
Pharmacogenet Genomics
The most common adverse drug reaction from statins are statin-associated muscle symptoms (SAMS), characterized by myopathy (weakness), myalgia (muscle pain), and commonly elevation in serum creatine kinase. All statins are substrates of the organic a
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 17, Iss, Pp 53-55 (2018)
Molecular Genetics and Metabolism Reports
Molecular Genetics and Metabolism Reports
Pathogenic variants in the PGAM2 gene are associated with glycogen storage disease type X (GSDX) and is characterized by exercise induced muscle cramping, weakness, myoglobinuria, and often tubular aggregates in skeletal muscle. We report here a pati
Autor:
Robert Schoenaker, Kathryn M. Camp, Valentina Emmanuele, Gregory M. Enns, Xiomara Q Rosales, Sumit Parikh, Richard Buchsbaum, Peter W. Stacpoole, Johan L.K. Van Hove, Austin Larson, Susanne D. DeBrosse, Andrea L. Gropman, Russell P. Saneto, Ralitza H. Gavrilova, Kristin Engelstad, Zarazuela Zolkipli-Cunningham, Richard Haas, Victoria Cooley, Danuta Krotoski, Jaya Ganesh, Salvatore DiMauro, John L.P. Thompson, Mark A. Tarnopolsky, Michio Hirano, Marni J. Falk, Georgirene D. Vladutiu, Emanuele Barca, Johnston Grier, Amy Goldstein, Joshua Kriger, Fernando Scaglia, Yuelin Long, Bruce H. Cohen, Jirair K. Bedoyan, Amel Karaa
Publikováno v:
Neurology: Genetics
ObjectiveTo describe clinical, biochemical, and genetic features of participants with mitochondrial diseases (MtDs) enrolled in the North American Mitochondrial Disease Consortium (NAMDC) Registry.MethodsThis cross-sectional, multicenter, retrospecti
Autor:
Smitha R. James, Jonathan E. Bard, Paul J. Isackson, Jianxin Wang, Tae Keun Lee, Adrian Levesque, Paul Spurgeon, Norma J. Nowak, Mohammad Zia, Georgirene D. Vladutiu
Aim: To examine the genetic differences between subjects with statin-associated muscle symptoms and statin-tolerant controls. Materials & methods: Next-generation sequencing was used to characterize the exomes of 76 subjects with severe statin-associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf4b22dcf0fcb75125fba11d20359a5
https://europepmc.org/articles/PMC6563124/
https://europepmc.org/articles/PMC6563124/
Autor:
Mark A. Tarnopolsky, Paul J. Isackson, Robert L. Wortmann, Georgirene D. Vladutiu, Chang-Xing Ma, Joseph P Kitzmiller, Lisa Christopher-Stine, Jasmine A. Luzum, Heather M. Ochs-Balcom, Ly Minh Nguyen, Michael H. Weisman, Wendy Peltier
Publikováno v:
Musclenerve. 59(5)
Introduction Statins reduce cardiovascular disease risk and are generally well tolerated, yet up to 0.5% of statin-treated patients develop incapacitating muscle symptoms including rhabdomyolysis. Our objective was to identify clinical factors relate
Autor:
Michael Roden, Alberico L. Catapano, Erik S.G. Stroes, Georgirene D. Vladutiu, Børge G. Nordestgaard, Baris Gencer, Paul D. Thompson, Robert A. Hegele, Henry N. Ginsberg, Jane K Stock, G. Kees Hovingh, Alberto Corsini, Raul D. Santos, Winfried März, Ulrich Laufs, Lawrence A. Leiter, Lale Tokgozoglu, Eric Bruckert, Terry A. Jacobson, Kausik K. Ray, Guy De Backer, François Mach, M. John Chapman, Olov Wiklund, Ronald M. Krauss, Frederick J. Raal, Evan A. Stein
Publikováno v:
European Atherosclerosis Society Consensus Panel 2018, ' Adverse effects of statin therapy : perception vs. the evidence-focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract ', European Heart Journal, vol. 39, no. 27, pp. 2526-2539 . https://doi.org/10.1093/eurheartj/ehy182
European heart journal, vol 39, iss 27
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
European Heart Journal
European heart journal, vol 39, iss 27
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
European Heart Journal
Aims: To objectively appraise evidence for possible adverse effects of long-term statin therapy on glucose homeostasis, cognitive, renal and hepatic function, and risk for haemorrhagic stroke or cataract.Methods and results: A literature search cover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f6e225d2d07a2b232702705a629dc0
https://curis.ku.dk/portal/da/publications/adverse-effects-of-statin-therapy(b2d7cbca-5095-4c15-87bc-17a79ace9147).html
https://curis.ku.dk/portal/da/publications/adverse-effects-of-statin-therapy(b2d7cbca-5095-4c15-87bc-17a79ace9147).html
Autor:
Anees M. Dauki, Joseph P Kitzmiller, Marisa W. Medina, Eduard B. Mikulik, Heather M. Ochs-Balcom, Paul J. Isackson, Chang-Xing Ma, Jasmine A. Luzum, Georgirene D. Vladutiu
Publikováno v:
Cell Metabolism. 21(4):622-627
Summary Statin-induced myopathy (SIM) is the most common reason for discontinuation of statin therapy. A polymorphism affecting the gene encoding glycine amidinotransferase ( GATM rs9806699 G > A) was previously associated with reduced risk for SIM.
Publikováno v:
Journal of neuromuscular diseases. 4(1)
BACKGROUND Statins have well-known benefits in the prevention of cardiovascular disease, however, 7-29% of patients develop muscle side effects and up to 0.5% develop severe symptoms. Mitochondrial dysfunction has been associated with severe statin-i
Publikováno v:
Muscle & Nerve. 47:224-229
Introduction: Twenty-six patients with clinical symptoms of adult onset carnitine palmitoyltransferase II (CPTII) deficiency were examined. All patients had skeletal muscle CPTII enzyme activity levels indicative of heterozygosity for CPT2 mutations,