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Convection-enhanced delivery of [ ¹⁷⁷ Lu]Lu-labeled gold nanoparticles combined with anti-PD1 checkpoint immunotherapy improves the survival of immunocompetent C57BL/6J mice with orthotopic GL261 murine glioma tumors.

Autor: Georgiou CJ; Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada., Brown MK; Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada., Cai Z; Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada., Alshafai L; Department of Medical Imaging, University of Toronto, Toronto, ON, Canada; Joint Department of Medical Imaging, Division of Neuroradiology, Mount Sinai Hospital and University Health Network, Toronto, ON, Canada., Gao A; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Laboratory Medicine Program, University Health Network, Toronto, ON, Canada., Rutka JT; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada., Winnik MA; Department of Chemistry, University of Toronto, Toronto, ON, Canada., Reilly RM; Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada; Department of Medical Imaging, University of Toronto, Toronto, ON, Canada; Laboratory Medicine Program, University Health Network, Toronto, ON, Canada. Electronic address: raymond.reilly@utoronto.ca.

Publikováno v: Nuclear medicine and biology [Nucl Med Biol] 2024 Nov 09; Vol. 140-141, pp. 108970. Date of Electronic Publication: 2024 Nov 09.

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Akademický článek

Radiation nanomedicines for cancer treatment: a scientific journey and view of the landscape.

Autor: Reilly RM; Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada. raymond.reilly@utoronto.ca.; Princess Margaret Cancer Centre, Toronto, ON, Canada. raymond.reilly@utoronto.ca.; Department of Medical Imaging, University of Toronto, Toronto, ON, Canada. raymond.reilly@utoronto.ca.; Joint Department of Medical Imaging, University Health Network, Toronto, ON, Canada. raymond.reilly@utoronto.ca.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, M5S 3M2, Canada. raymond.reilly@utoronto.ca., Georgiou CJ; Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada., Brown MK; Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada., Cai Z; Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada.

Publikováno v: EJNMMI radiopharmacy and chemistry [EJNMMI Radiopharm Chem] 2024 May 04; Vol. 9 (1), pp. 37. Date of Electronic Publication: 2024 May 04.

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Akademický článek

Adjuvant Auger Electron-Emitting Radioimmunotherapy with [ ¹¹¹ In]In-DOTA-Panitumumab in a Mouse Model of Local Recurrence and Metastatic Progression of Human Triple-Negative Breast Cancer.

Autor: Facca VJ; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College St., Toronto, Ontario M5S 3M2, Canada., Cai Z; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College St., Toronto, Ontario M5S 3M2, Canada., Ku A; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College St., Toronto, Ontario M5S 3M2, Canada., Georgiou CJ; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College St., Toronto, Ontario M5S 3M2, Canada., Reilly RM; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College St., Toronto, Ontario M5S 3M2, Canada.; Department of Medical Imaging, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Joint Department of Medical Imaging and Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2C1, Canada.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2023 Dec 04; Vol. 20 (12), pp. 6407-6419. Date of Electronic Publication: 2023 Nov 20.

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Akademický článek

Treatment of Orthotopic U251 Human Glioblastoma Multiforme Tumors in NRG Mice by Convection-Enhanced Delivery of Gold Nanoparticles Labeled with the β-Particle-Emitting Radionuclide, ¹⁷⁷ Lu.

Autor: Georgiou CJ; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, OntarioM5S 3M2, Canada., Cai Z; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, OntarioM5S 3M2, Canada., Alsaden N; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, OntarioM5S 3M2, Canada., Cho H; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, OntarioM5S 3H6, Canada., Behboudi M; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, OntarioM5S 3M2, Canada., Winnik MA; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, OntarioM5S 3H6, Canada., Rutka JT; Division of Neurosurgery, The Hospital for Sick Children, 555 University Avenue, Toronto, OntarioM5G 1X8, Canada.; Division of Neurosurgery, Department of Surgery, Temerty Faculty of Medicine, University of Toronto, 149 College Street, Toronto, OntarioM5T 1P5, Canada., Reilly RM; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, OntarioM5S 3M2, Canada.; Department of Medical Imaging, Temerty Faculty of Medicine, University of Toronto, Toronto, OntarioM5S 1A8, Canada.; Joint Department of Medical Imaging and Princess Margaret Cancer Centre, University Health Network, Toronto, OntarioM5G 2C1, Canada.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2023 Jan 02; Vol. 20 (1), pp. 582-592. Date of Electronic Publication: 2022 Dec 14.

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Cellular dosimetry of ¹⁹⁷ Hg, ^197m Hg and ¹¹¹ In: comparison of dose deposition and identification of the cell and nuclear membrane as important targets.

Autor: Cai Z; Department of Pharmaceutical Sciences, University of Toronto, Toronto, Canada., Al-Saden N; Department of Pharmaceutical Sciences, University of Toronto, Toronto, Canada., Georgiou CJ; Department of Pharmaceutical Sciences, University of Toronto, Toronto, Canada., Reilly RM; Department of Pharmaceutical Sciences, University of Toronto, Toronto, Canada.; Department of Medical Imaging, University of Toronto, Toronto, Canada.; Princess Margaret Cancer Centre and Joint Department of Medical Imaging, University Health Network, Toronto, Canada.

Publikováno v: International journal of radiation biology [Int J Radiat Biol] 2023; Vol. 99 (1), pp. 53-63. Date of Electronic Publication: 2020 Dec 16.

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