Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Georgios Skiniotis"'
Autor:
Kaavya Krishna Kumar, Michael J. Robertson, Elina Thadhani, Haoqing Wang, Carl-Mikael Suomivuori, Alexander S. Powers, Lipin Ji, Spyros P. Nikas, Ron O. Dror, Asuka Inoue, Alexandros Makriyannis, Georgios Skiniotis, Brian Kobilka
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Endocannabinoids (eCBs) are endogenous ligands of the cannabinoid receptor 1 (CB1), a G protein-coupled receptor that regulates a number of therapeutically relevant physiological responses. Hence, understanding the structural and functional
Externí odkaz:
https://doaj.org/article/71d62685464f40ccbb9b372800929824
Autor:
Geng Chen, Xiankun Wang, Qiwen Liao, Yunjun Ge, Haizhan Jiao, Qiang Chen, Yezhou Liu, Wenping Lyu, Lizhe Zhu, Gydo C. P. van Zundert, Michael J. Robertson, Georgios Skiniotis, Yang Du, Hongli Hu, Richard D. Ye
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Detection of invading bacteria is key to immunity. Here, the authors report cryo-electron microscopy structures of agonist-bound formyl peptide receptor 1 (FPR1), that reveal structural basis for recognition of bacteria-derived formyl peptides.
Externí odkaz:
https://doaj.org/article/213ab71046034930b5702d46eba98f44
Autor:
Luke F. Pennington, Pascal Gasser, Silke Kleinboelting, Chensong Zhang, Georgios Skiniotis, Alexander Eggel, Theodore S. Jardetzky
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Facilitated dissociation is a mechanism where antibody-mediated disruption of high-affinity complexes can enhance the therapeutic effects of a drug. Here the authors present a yeast display approach to select and engineer omalizumab variants that dis
Externí odkaz:
https://doaj.org/article/ce93054282b0409585dfb3dd0b17d1d1
Autor:
Yamuna Kalyani Mathiharan, Ian W. Glaaser, Yulin Zhao, Michael J. Robertson, Georgios Skiniotis, Paul A. Slesinger
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109619- (2021)
Summary: G-protein-gated inwardly rectifying potassium (GIRK) channels are important for determining neuronal excitability. In addition to G proteins, GIRK channels are potentiated by membrane cholesterol, which is elevated in the brains of people wi
Externí odkaz:
https://doaj.org/article/959412e4de4b446ba8d44e4d35df82c8
Autor:
Wei Kan, Michael D Enos, Elgin Korkmazhan, Stefan Muennich, Dong-Hua Chen, Melissa V Gammons, Mansi Vasishtha, Mariann Bienz, Alexander R Dunn, Georgios Skiniotis, William I Weis
Publikováno v:
eLife, Vol 9 (2020)
In Wnt/β-catenin signaling, the transcriptional coactivator β-catenin is regulated by its phosphorylation in a complex that includes the scaffold protein Axin and associated kinases. Wnt binding to its coreceptors activates the cytosolic effector D
Externí odkaz:
https://doaj.org/article/909d22a097d24da0a1d1f2431d614ce4
Autor:
Alpay Burak Seven, Daniel Hilger, Makaía M. Papasergi-Scott, Li Zhang, Qianhui Qu, Brian K. Kobilka, Gregory G. Tall, Georgios Skiniotis
Publikováno v:
Cell Reports, Vol 30, Iss 11, Pp 3699-3709.e6 (2020)
Summary: Many chaperones promote nascent polypeptide folding followed by substrate release through ATP-dependent conformational changes. Here we show cryoEM structures of Gα subunit folding intermediates in complex with full-length Ric-8A, a unique
Externí odkaz:
https://doaj.org/article/17f4656dd6a64188bc8fbddf98884eac
Autor:
Shoji Maeda, Antoine Koehl, Hugues Matile, Hongli Hu, Daniel Hilger, Gebhard F. X. Schertler, Aashish Manglik, Georgios Skiniotis, Roger J. P. Dawson, Brian K. Kobilka
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
The determination of high resolution structures of G protein coupled receptors (GPCRs) in complex with heterotrimeric G proteins is challenging. Here authors develop an antibody fragment, mAB16, which stabilizes GPCR/G-protein complexes and facilitat
Externí odkaz:
https://doaj.org/article/78767849a46d4536a969df36dd817784
Autor:
Moran Shalev-Benami, Yan Zhang, Haim Rozenberg, Yuko Nobe, Masato Taoka, Donna Matzov, Ella Zimmerman, Anat Bashan, Toshiaki Isobe, Charles L. Jaffe, Ada Yonath, Georgios Skiniotis
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Leishmaniasis is a parasitic disease transmitted by the bite of infected sand flies. Here the authors describe an atomic resolution cryo-EM structure of the Leishmania ribosome in complex with the recently approved drug paromomycin (PAR) and highligh
Externí odkaz:
https://doaj.org/article/4b7b9a6e66c84f36a4b0e669a2a51d88
Autor:
Moran Shalev-Benami, Yan Zhang, Donna Matzov, Yehuda Halfon, Arie Zackay, Haim Rozenberg, Ella Zimmerman, Anat Bashan, Charles L. Jaffe, Ada Yonath, Georgios Skiniotis
Publikováno v:
Cell Reports, Vol 16, Iss 2, Pp 288-294 (2016)
Leishmania is a single-cell eukaryotic parasite of the Trypanosomatidae family, whose members cause an array of tropical diseases. The often fatal outcome of infections, lack of effective vaccines, limited selection of therapeutic drugs, and emerging
Externí odkaz:
https://doaj.org/article/6b7985b7448545f39a7420e4af650987
Autor:
Kai Xu, Yee-Peng Chan, Birgit Bradel-Tretheway, Zeynep Akyol-Ataman, Yongqun Zhu, Somnath Dutta, Lianying Yan, YanRu Feng, Lin-Fa Wang, Georgios Skiniotis, Benhur Lee, Z Hong Zhou, Christopher C Broder, Hector C Aguilar, Dimitar B Nikolov
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005322 (2015)
Nipah virus (NiV) is a paramyxovirus that infects host cells through the coordinated efforts of two envelope glycoproteins. The G glycoprotein attaches to cell receptors, triggering the fusion (F) glycoprotein to execute membrane fusion. Here we repo
Externí odkaz:
https://doaj.org/article/d7d53e34d8c04943b73c50bfbe07fb34