Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Georgios Pavlou"'
Autor:
Thomas L. Maurissen, Alena J. Spielmann, Gabriella Schellenberg, Marc Bickle, Jose Ricardo Vieira, Si Ying Lai, Georgios Pavlou, Sascha Fauser, Peter D. Westenskow, Roger D. Kamm, Héloïse Ragelle
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Diabetic retinopathy (DR) is a microvascular disorder characterized by inner blood-retinal barrier (iBRB) breakdown and irreversible vision loss. While the symptoms of DR are known, disease mechanisms including basement membrane thickening,
Externí odkaz:
https://doaj.org/article/ec45dba5d88548cbb695e377fc41e056
Autor:
Zhengpeng Wan, Shun Zhang, Amy X. Zhong, Liling Xu, Mark F. Coughlin, Georgios Pavlou, Sarah E. Shelton, Huu Tuan Nguyen, Satomi Hirose, Seunggyu Kim, Marie A. Floryan, David A. Barbie, F. Stephen Hodi, Roger D. Kamm
Publikováno v:
Advanced Science, Vol 11, Iss 26, Pp n/a-n/a (2024)
Abstract Endothelial programmed death‐ligand 1 (PD‐L1) expression is higher in tumors than in normal tissues. Also, tumoral vasculatures tend to be leakier than normal vessels leading to a higher trans‐endothelial or transmural fluid flow. Howe
Externí odkaz:
https://doaj.org/article/e0b6d2b3cd9a4d6185b943c5ce795bda
Autor:
Eunkyung Clare Ko, Sarah Spitz, Francesca Michela Pramotton, Olivia M. Barr, Ciana Xu, Georgios Pavlou, Shun Zhang, Alice Tsai, Anna Maaser-Hecker, Mehdi Jorfi, Se Hoon Choi, Rudolph E. Tanzi, Roger D. Kamm
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
High failure rates in clinical trials for neurodegenerative disorders such as Alzheimer’s disease have been linked to an insufficient predictive validity of current animal-based disease models. This has created an increasing demand for alternative,
Externí odkaz:
https://doaj.org/article/5f0f854d8b8b434c9d0077855ad08b9d
Autor:
Claire Siebert, Corinne Villers, Georgios Pavlou, Bastien Touquet, Nandadeva Yakandawala, Isabelle Tardieux, Patricia Renesto
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228591 (2020)
Biofilms are currently considered as a predominant lifestyle of many bacteria in nature. While they promote survival of microbes, biofilms also potentially increase the threats to animal and public health in case of pathogenic species. They not only
Externí odkaz:
https://doaj.org/article/c5e634395def48b9b77349408726bacf
Publikováno v:
Advanced functional materials. 32(43)
Self-organized microvascular networks (MVNs) have become key to the development of many microphysiological models. However, the self-organizing nature of this process combined with variations between types or batches of endothelial cells (ECs) often
Autor:
Justin Rustenhoven, Georgios Pavlou, Steffen E. Storck, Taitea Dykstra, Siling Du, Zhengpeng Wan, Daniel Quintero, Joshua P. Scallan, Igor Smirnov, Roger D. Kamm, Jonathan Kipnis
Publikováno v:
Journal of Experimental Medicine. 220
The meningeal lymphatic network enables the drainage of cerebrospinal fluid (CSF) and facilitates the removal of central nervous system (CNS) waste. During aging and in Alzheimer’s disease, impaired meningeal lymphatic drainage promotes the buildup
Autor:
Zhengpeng Wan, Amy X. Zhong, Shun Zhang, Georgios Pavlou, Mark F. Coughlin, Sarah E. Shelton, Huu Tuan Nguyen, Jochen H. Lorch, David A. Barbie, Roger D. Kamm
Publikováno v:
Small methods. 6(6)
Micropost-based microfluidic devices are widely used for microvascular network (MVN) formation in diverse research fields. However, consistently generating perfusable MVNs of physiological morphology and dimension has proven to be challenging. Here,
Autor:
Thomas L. Maurissen, Georgios Pavlou, Colette Bichsel, Roberto Villaseñor, Roger D. Kamm, Héloïse Ragelle
Publikováno v:
Journal of personalized medicine. 12(2)
Blood-neural barriers regulate nutrient supply to neuronal tissues and prevent neurotoxicity. In particular, the inner blood-retinal barrier (iBRB) and blood–brain barrier (BBB) share common origins in development, and similar morphology and functi
Publikováno v:
Advanced Functional Materials. 32:2206767
Autor:
Delphine Débarre, Isabelle Tardieux, Patricia Renesto, Georgios Pavlou, Luis Vigetti, Bastien Touquet, Alexandre Bougdour, Martial Balland
Publikováno v:
ACS Nano
ACS Nano, American Chemical Society, 2020, 14 (6), pp.7121-7139. ⟨10.1021/acsnano.0c01893⟩
ACS Nano, 2020, 14 (6), pp.7121-7139. ⟨10.1021/acsnano.0c01893⟩
ACS Nano, American Chemical Society, 2020, 14 (6), pp.7121-7139. ⟨10.1021/acsnano.0c01893⟩
ACS Nano, 2020, 14 (6), pp.7121-7139. ⟨10.1021/acsnano.0c01893⟩
International audience; Among the eukaryotic cells that navigate through fully developed metazoan tissues, protozoans from the Apicomplexa phylum have evolved motile developmental stages that move much faster than the fastest crawling cells owing to