Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Georgios Leonis"'
Autor:
Vasiliki Palli, Georgios Leonis, Nikoletta Zoupanou, Nikitas Georgiou, Maria Chountoulesi, Nikolaos Naziris, Demeter Tzeli, Costas Demetzos, Georgia Valsami, Konstantinos D. Marousis, Georgios A. Spyroulias, Thomas Mavromoustakos
Publikováno v:
Molecules, Vol 27, Iss 8, p 2421 (2022)
Losartan potassium salt (LSR) is a well-known antihypertensive drug with proven beneficial effects on human health. Its formulation with the non-toxic 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD) could improve its pharmacological profile. Thus, its m
Externí odkaz:
https://doaj.org/article/0590c7bb45b545318a939083bae8753b
Autor:
Georgia Melagraki, Evangelos Ntougkos, Dimitra Papadopoulou, Vagelis Rinotas, Georgios Leonis, Eleni Douni, Antreas Afantitis, George Kollias
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
An in silico drug discovery pipeline for the virtual screening of plant-origin natural products (NPs) was developed to explore new direct inhibitors of TNF and its close relative receptor activator of nuclear factor kappa-B ligand (RANKL), both repre
Externí odkaz:
https://doaj.org/article/9e601601f8714aa29c0759fc62551690
Autor:
Georgia Melagraki, Evangelos Ntougkos, Vagelis Rinotas, Christos Papaneophytou, Georgios Leonis, Thomas Mavromoustakos, George Kontopidis, Eleni Douni, Antreas Afantitis, George Kollias
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 4, p e1005372 (2017)
We present an in silico drug discovery pipeline developed and applied for the identification and virtual screening of small-molecule Protein-Protein Interaction (PPI) compounds that act as dual inhibitors of TNF and RANKL through the trimerization in
Externí odkaz:
https://doaj.org/article/bb8badfc680d46728e9988d005f3b0c7
Autor:
Georgios Leonis, Vasiliki Vakali, Nikoletta Zoupanou, Nikitas Georgiou, Demeter Tzeli, Dimitrios A. Diamantis, Andreas G. Tzakos, Thomas Mauromoustakos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::701f9bdf506ae3a77f25b2e40b1120b8
https://doi.org/10.2139/ssrn.4399273
https://doi.org/10.2139/ssrn.4399273
Autor:
Dimitrios Ntountaniotis, Eirini Christodoulou, Dimitrios Damalas, Georgios Liapakis, Georgia Valsami, Vlasios Karageorgos, Nikolaos Naziris, Nikolaos S. Thomaidis, Thomas Mavromoustakos, Maria V. Chatziathanasiadou, Andreas G. Tzakos, Maria Chountoulesi, Georgios Leonis, Costas Demetzos
Publikováno v:
Chemical Biology & Drug Design. 96:668-683
Irbesartan (IRB) exerts beneficial effects either alone or in combination with other drugs on numerous diseases, such as cancer, diabetes, and hypertension. However, due to its high lipophilicity, IRB does not possess the optimum pharmacological effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1056b9b60da28e5e32bbb7e21dfe0567
https://doi.org/10.1111/cbdd.13664
https://doi.org/10.1111/cbdd.13664
Autor:
Dimitrios Damalas, George Liapakis, Ioannis Andreadelis, Andreas G. Tzakos, Johanna Becker-Baldus, Antonios Kolocouris, Sofia Kiriakidi, Uroš Javornik, Thomas Mavromoustakos, Evgenios K. Stylos, Eirini Christodoulou, Nikolaos S. Thomaidis, Busecan Aksoydan, Georgios Leonis, Dimitrios Ntountaniotis, Clemens Glaubitz, Janez Plavec, Vlasios Karageorgos, Maria V. Chatziathanasiadou, Tahsin F. Kellici, Serdar Durdagi, Georgia Valsami, Christos M. Chatzigiannis
Publikováno v:
Molecular Pharmaceutics. 16:1255-1271
Renin-angiotensin aldosterone system inhibitors are for a long time extensively used for the treatment of cardiovascular and renal diseases. AT1 receptor blockers (ARBs or sartans) act as antihypertensive drugs by blocking the octapeptide hormone Ang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df16f0bae18c64d98bd66bd6d7f4cc9e
https://doi.org/10.1021/acs.molpharmaceut.8b01212
https://doi.org/10.1021/acs.molpharmaceut.8b01212
Autor:
Thomas Mavromoustakos, Georgia Valsami, Georgios Leonis, Eirini Christodoulou, Dimitrios Ntountaniotis
Publikováno v:
Supramolecules in Drug Discovery and Drug Delivery ISBN: 9781071609194
Bioavailability of active substances is of great importance for the formulation of a drug product, as it actually reflects drug absorption and achievement of the optimum pharmacological effect. A great number of chemical compounds with excellent phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2b175640dbaa2840873df2c02dfc66d
https://doi.org/10.1007/978-1-0716-0920-0_1
https://doi.org/10.1007/978-1-0716-0920-0_1
Publikováno v:
Supramolecules in Drug Discovery and Drug Delivery ISBN: 9781071609194
NMR spectroscopy is an effective technique, applicable for studying bioactive materials or drug delivery systems in order to obtain comprehensive details related to structural and dynamic characteristics at atomic resolution. The applications of NMR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65145030e13312c672d32cbe3f50dfe1
https://doi.org/10.1007/978-1-0716-0920-0_22
https://doi.org/10.1007/978-1-0716-0920-0_22
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2207
Hypertension treatment is a current therapeutic priority as there is a constantly increasing part of the population that suffers from this risk factor, which may lead to cardiovascular and encephalic episodes and eventually to death. A number of mark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::87c74fcc3ee702f51da02eead70c0045
https://pubmed.ncbi.nlm.nih.gov/33113131
https://pubmed.ncbi.nlm.nih.gov/33113131
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2207
NMR spectroscopy is an effective technique, applicable for studying bioactive materials or drug delivery systems in order to obtain comprehensive details related to structural and dynamic characteristics at atomic resolution. The applications of NMR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0658b436796f048a0af4cc7b1f289787
https://pubmed.ncbi.nlm.nih.gov/33113144
https://pubmed.ncbi.nlm.nih.gov/33113144