Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Georgios, Kanellos"'
Autor:
Owen J. Sansom, Martin Bushell, Anne E. Willis, Joanne Edwards, John Le Quesne, William J. Faller, Heather J. McKinnon, Martin E. Swarbrick, Neil P. Jones, Christopher G. Proud, Nahum Sonenberg, Kevin M. Haigis, Nicola Valeri, Georgios Vlachogiannis, Andrew D. Campbell, Joseph A. Waldron, Rene Jackstadt, Joshua D. Leach, Emma Stanway, Kerri McArthur, Anne Cheasty, Craig MacKay, Laura McDonald, Rachael C.L. Smith, Dustin J. Flanagan, Rachel A. Ridgway, Kathryn Gilroy, Arafath K. Najumudeen, Ewan M. Smith, Sebastian May-Wilson, David M. Gay, Georgios Kanellos, Ana Teodosio, Leah Officer, Kathryn Pennel, Nikola Vlahov, George L. Skalka, Constantinos Alexandrou, John R.P. Knight
All supplemental figures and legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cee3a26e547749f005f869f86f6004e
https://doi.org/10.1158/2159-8290.22540555
https://doi.org/10.1158/2159-8290.22540555
Autor:
Owen J. Sansom, Martin Bushell, Anne E. Willis, Joanne Edwards, John Le Quesne, William J. Faller, Heather J. McKinnon, Martin E. Swarbrick, Neil P. Jones, Christopher G. Proud, Nahum Sonenberg, Kevin M. Haigis, Nicola Valeri, Georgios Vlachogiannis, Andrew D. Campbell, Joseph A. Waldron, Rene Jackstadt, Joshua D. Leach, Emma Stanway, Kerri McArthur, Anne Cheasty, Craig MacKay, Laura McDonald, Rachael C.L. Smith, Dustin J. Flanagan, Rachel A. Ridgway, Kathryn Gilroy, Arafath K. Najumudeen, Ewan M. Smith, Sebastian May-Wilson, David M. Gay, Georgios Kanellos, Ana Teodosio, Leah Officer, Kathryn Pennel, Nikola Vlahov, George L. Skalka, Constantinos Alexandrou, John R.P. Knight
KRAS-mutant colorectal cancers are resistant to therapeutics, presenting a significant problem for ∼40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis, are significantly less potent in KRAS-mutant colorectal cancer. Using Kras-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f56670615fce027f717d8d9f47081b8
https://doi.org/10.1158/2159-8290.c.6549409
https://doi.org/10.1158/2159-8290.c.6549409
Autor:
Georgios Kanellos, Jing Zhou, Hitesh Patel, Rachel A. Ridgway, David Huels, Christine B. Gurniak, Emma Sandilands, Neil O. Carragher, Owen J. Sansom, Walter Witke, Valerie G. Brunton, Margaret C. Frame
Publikováno v:
Cell Reports, Vol 13, Iss 9, Pp 1949-1964 (2015)
Genetic co-depletion of the actin-severing proteins ADF and CFL1 triggers catastrophic loss of adult homeostasis in multiple tissues. There is impaired cell-cell adhesion in skin keratinocytes with dysregulation of E-cadherin, hyperproliferation of d
Externí odkaz:
https://doaj.org/article/68d74766f9794e91b13d8444278d7b47
Autor:
Anne E. Willis, Laura McDonald, George Skalka, Andrew D. Campbell, Heather McKinnon, Kevin M. Haigis, John R. P. Knight, Sebastian May-Wilson, Kathryn Gilroy, William J. Faller, Emma Stanway, Leah Officer, Rachael C. L. Smith, Joshua D.G. Leach, Joseph A. Waldron, Rachel A. Ridgway, Nicola Valeri, Ewan M. Smith, Arafath Kaja Najumudeen, Nahum Sonenberg, Joanne Edwards, Rene Jackstadt, Ana Teodósio, John Le Quesne, Dustin J. Flanagan, Anne Cheasty, Georgios Kanellos, Kerri McArthur, Christopher G. Proud, Constantinos Alexandrou, Georgios Vlachogiannis, Neil P. Jones, Nikola Vlahov, Owen J. Sansom, Kathryn Af Pennel, Craig MacKay, Martin E. Swarbrick, Martin Bushell
Publikováno v:
Knight, J R P, Alexandrou, C, Skalka, G L, Vlahov, N, Pennel, K, Officer, L, Teodosio, A, Kanellos, G, Gay, D M, May-Wilson, S, Smith, E M, Najumudeen, A K, Gilroy, K, Ridgway, R A, Flanagan, D J, Smith, R C L, McDonald, L, MacKay, C, Cheasty, A, McArthur, K, Stanway, E, Leach, J D, Jackstadt, R, Waldron, J A, Campbell, A D, Vlachogiannis, G, Valeri, N, Haigis, K M, Sonenberg, N, Proud, C G, Jones, N P, Swarbrick, M E, McKinnon, H J, Faller, W J, Quesne, J L, Edwards, J, Willis, A E, Bushell, M & Sansom, O J 2021, ' MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression ', Cancer discovery, vol. 11, no. 5, pp. 1228-1247 . https://doi.org/10.1158/2159-8290.CD-20-0652
KRAS-mutant colorectal cancers are resistant to therapeutics, presenting a significant problem for ∼40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis, are significantly less potent in KRAS-mutant colorectal cancer. Using Kras-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b093ca20383c7ab94bac414895dbf3
https://doi.org/10.1158/2159-8290.CD-20-0652
https://doi.org/10.1158/2159-8290.CD-20-0652
Autor:
John R P, Knight, Constantinos, Alexandrou, George L, Skalka, Nikola, Vlahov, Kathryn, Pennel, Leah, Officer, Ana, Teodosio, Georgios, Kanellos, David M, Gay, Sebastian, May-Wilson, Ewan M, Smith, Arafath K, Najumudeen, Kathryn, Gilroy, Rachel A, Ridgway, Dustin J, Flanagan, Rachael C L, Smith, Laura, McDonald, Craig, MacKay, Anne, Cheasty, Kerri, McArthur, Emma, Stanway, Joshua D, Leach, Rene, Jackstadt, Joseph A, Waldron, Andrew D, Campbell, Georgios, Vlachogiannis, Nicola, Valeri, Kevin M, Haigis, Nahum, Sonenberg, Christopher G, Proud, Neil P, Jones, Martin E, Swarbrick, Heather J, McKinnon, William J, Faller, John, Le Quesne, Joanne, Edwards, Anne E, Willis, Martin, Bushell, Owen J, Sansom
Publikováno v:
Cancer Discov
KRAS-mutant colorectal cancers (CRC) are resistant to therapeutics, presenting a significant problem for ~40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis, are significantly less potent in KRAS-mutant CRC. Using Kras-mutant mou
Autor:
Margaret C. Frame, Georgios Kanellos
Publikováno v:
Kanellos, G & Frame, M C 2016, ' Cellular functions of the ADF/cofilin family at a glance ', Journal of Cell Science . https://doi.org/10.1242/jcs.187849
The actin depolymerizing factor (ADF)/cofilin family comprises small actin-binding proteins with crucial roles in development, tissue homeostasis and disease. They are best known for their roles in regulating actin dynamics by promoting actin treadmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb14bfdcb2bab16add3bfb04952a580f
https://hdl.handle.net/20.500.11820/aec2730f-076b-4322-b0ba-4a041af312cd
https://hdl.handle.net/20.500.11820/aec2730f-076b-4322-b0ba-4a041af312cd