Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response

Autor: Julia Merkenschlager, Mickaël J. Ploquin, Urszula Eksmond, Rakieb Andargachew, Georgina Thorborn, Andrew Filby, Marion Pepper, Brian Evavold, George Kassiotis

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

During an immune response, CD4+ T cell repertoire is thought to increase in avidity at the expense of diversity. Here the authors show that B cells act as antigen-presenting cells to boost the development of low-avidity T cell clones, diversifying th

Externí odkaz: https://doaj.org/article/25bffa91449947648b99e2c787621c0f

Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial

Autor: Robert J Moots, Pier Paolo Sainaghi, Mattia Congia, Bernard Lauwerys, Rebecca Hands, Christopher Holroyd, Nagui Gendi, Carlomaurizio Montecucco, Louise Warren, Ernest Choy, Gaye Hadfield, Serena Bugatti, Mattia Bellan, Joanna Peel, Georgina Thorborn, Arthur G. Pratt, Julio A. Ramirez, Vasco C. Romão, Nora Ng, Stephen Kelly, John D. Isaacs, Felice Rivellese, Raquel Celis, Peter C. Taylor, Christopher J Edwards, Frances Humby, Giovanni Giorli, Patrick Verschueren, Maya H Buch, Costantino Pitzalis, Pauline Ho, Alessandra Nerviani, Piero Reynolds, Charlotte Thompson, Liliane Fossati-Jimack, João Eurico Fonseca, Juan D. Cañete, Peter Sasieni, Patrick Durez, Myles Lewis, Alberto Cauli, Arti Mahto, Laura White, Bhaskar Dasgupta, Hasan Rizvi, Michele Bombardieri

Publikováno v: Lancet (London, England), Vol. 397, no.10271, p. 305-317 (2021)
Lancet (London, England)

BACKGROUND: Although targeted biological treatments have transformed the outlook for patients with rheumatoid arthritis, 40% of patients show poor clinical response, which is mechanistically still unexplained. Because more than 50% of patients with r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a4419f1b41fe39d86f0860907ba70e
https://doi.org/10.1016/s0140-6736(20)32341-2

B Cell Synovitis and Clinical Phenotypes in Rheumatoid Arthritis: Relationship to Disease Stages and Drug Exposure

Autor: Myles Lewis, Katriona Goldmann, Hasan Rizvi, Frances Humby, Davide Lucchesi, Serena Bugatti, Giovanni Giorli, Liliane Fossati-Jimack, Antonio Manzo, Christopher R. John, Peac-R Ra Investigators, Barbara Frias, Alessandra Nerviani, Costantino Pitzalis, Edyta Jaworska, Michele Bombardieri, Georgina Thorborn, Felice Rivellese, Rebecca Hands, Gloria Lliso-Ribera

Publikováno v: Arthritis & rheumatology (Hoboken, N.J.), Vol. 72, no.5, p. 714-725 (2020)

Objective:To define the relationship of synovial B cells to clinical phenotypes at different stages of disease evolution and drug exposure in rheumatoid arthritis (RA). Methods:Synovial biopsy specimens and demographic and clinical data were collecte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718a6fad1fd18bf5a2217cd1207d91bf
https://hdl.handle.net/2078.1/261604

Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data

Autor: A. Gilmour, S Schwank, Frederic Geissmann, Christopher M Mela, B Kola, B Harvey, I Vranic, Evan Tzanis, H-D Zucht, Peter C. Taylor, J Diboll, Alexandra Belson, G Molyneux, MA Sleeman, Rekha Parmar, E Vernon, Stephen P. Young, Iona Donnelly, C Cuff, P Schulz-Knappe, Heidi Lempp, Christopher D. Buckley, N Payne, John D. Isaacs, Coziana Ciurtin, H Noble, M Macoritto, A Parke, S Jelinsky, James N. Galloway, Ian C. Scott, Frederique Ponchel, Sarah Keidel, Denny Verbeeck, A Didierlaurent, MF McDermot, J Tarn, AT Virlan, T Lazarov, J Ellis, S Kaymakcalan, Anthony Rowe, Catharien M. U. Hilkens, G Altobelli, M Loza, P Jones, Ayako Wakatsuki Pedersen, Ian N. Bruce, Duncan Porter, A Cuza, D Ziemek, S Talbot, C Marshall, A Herath, D Finch, D Baker, Maya H Buch, Y Zhong, R Toward, Ludbrook, Mark Coles, Barnes, M Ho, M Page, J Casement, M Maciejewski, Claudio Carini, Sarah Brockbank, D Nguyen, H Tipney, A Filer, Christopher R. John, S Kelly, Andrew P. Cope, W Burny, M Curran, Catharina Lindholm, Benjamin A Fisher, Ray Harris, Jehan J. El-Jawhari, P Stocks, D Dastros-Pitel, Z Liu, Bdm Tom, Dennis Lendrem, Wayne Tsuji, F Stirling, J Worthington, Deborah P M Symmons, Matthew A. Sleeman, D Padhji, Fowzia Ibrahim, Smm Verstappen, P Budde, Ehrenstein, Marc C. Levesque, R Harry, B Allen, T Sabin, Michael Binks, Sally Hollis, Gerry Parker, S Lipsky, Georgina Thorborn, M Jenkins, A Hughes-Morley, Costantino Pitzalis, N Joseph, H Edwards, Jamie C. Sergeant, Paul Emery, H Ali, JA Butler, Liliane Fossati-Jimack, S Wright, Fiona Clarke, W Wu, Amy E. Anderson, Sharmila Rana, F Humby, F Hong, Myles Lewis, A Haynes, Katriona Goldmann, S Martins, CT Mela, S Hasan, David Scott, L Rowell, David Watson, Neil Gozzard, Karim Raza, Simon Read, M Hodge, Carl S. Goodyear, Farewell, George Davey Smith, Michele Bombardieri, Iain B. McInnes, C Larminie, G Simpson, N Ward, K Hicks, R Rao, Z Jia, FB Capdevila, A Long

Publikováno v: RA-MAP Consortium, Tom, B & Symmons, D 2018, ' Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data ', RMD Open, vol. 4, no. 2, pp. e000721 . https://doi.org/10.1136/rmdopen-2018-000721
RMD Open

ObjectivesTo identify predictors of remission and disease activity patterns in patients with rheumatoid arthritis (RA) using individual participant data (IPD) from clinical trials.MethodsPhase II and III clinical trials completed between 2002 and 201

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b48a096d68180fc5745f1e771c2710f
https://doi.org/10.1136/rmdopen-2018-000721

Elevated effector cell sensitivity to Treg-cell suppression that is not associated with reduced Th17-cell expression distinguishes HIV+asymptomatic subjects from progressors

Autor: Georgina Thorborn, Barry Peters, Heidi Ishohanni, Annapurna Vyakarnam, Laura Pomeroy

Publikováno v: European Journal of Immunology. 42:138-146

Suppression mediated by Treg cells is a balance between Treg-cell suppressive potency versus sensitivity of effector cells to Treg-cell suppression. We assessed if this balance, along with Treg-cell number relative to the Treg-cell counter-regulatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f96f883e4d179c4d8138e15668c0bdb8
https://doi.org/10.1002/eji.201141426