Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response

Autor: Julia Merkenschlager, Mickaël J. Ploquin, Urszula Eksmond, Rakieb Andargachew, Georgina Thorborn, Andrew Filby, Marion Pepper, Brian Evavold, George Kassiotis

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

During an immune response, CD4+ T cell repertoire is thought to increase in avidity at the expense of diversity. Here the authors show that B cells act as antigen-presenting cells to boost the development of low-avidity T cell clones, diversifying th

Externí odkaz: https://doaj.org/article/25bffa91449947648b99e2c787621c0f

A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNFα-Blockade in Rheumatoid Arthritis Patients

Autor: Frances Humby, Georgina Thorborn, Daniele Mauro, Marie-Astrid Boutet, Arti Mahto, Maria Di Cicco, Felice Rivellese, Myles Lewis, Mattia Bellan, Rebecca Hands, Costantino Pitzalis, Giovanni Giorli, Gloria Lliso-Ribera, Michele Bombardieri, Stephen Kelly, Alessandra Nerviani

Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology

Objectives: To assess whether the histopathological features of the synovium before starting treatment with the TNFi certolizumab-pegol could predict clinical outcome and examine the modulation of histopathology by treatment. Methods: Thirty-seven RA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e8bdd6005ec769145efe6aa190c2f7
https://www.frontiersin.org/article/10.3389/fimmu.2020.00845/full

Increased sensitivity of CD4+ T-effector cells to CD4+CD25+ Treg suppression compensates for reduced Treg number in asymptomatic HIV-1 infection.

Autor: Georgina Thorborn, Laura Pomeroy, Heidi Isohanni, Melissa Perry, Barry Peters, Annapurna Vyakarnam

Publikováno v: PLoS ONE, Vol 5, Iss 2, p e9254 (2010)

BACKGROUND: In HIV infection, uncontrolled immune activation and disease progression is attributed to declining CD4+CD25+FoxP3+ regulatory T-cell (Treg) numbers. However, qualitative aspects of Treg function in HIV infection, specifically the balance

Externí odkaz: https://doaj.org/article/b5fb31a0743f48e19fed509770123065

Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data

Autor: A. Gilmour, S Schwank, Frederic Geissmann, Christopher M Mela, B Kola, B Harvey, I Vranic, Evan Tzanis, H-D Zucht, Peter C. Taylor, J Diboll, Alexandra Belson, G Molyneux, MA Sleeman, Rekha Parmar, E Vernon, Stephen P. Young, Iona Donnelly, C Cuff, P Schulz-Knappe, Heidi Lempp, Christopher D. Buckley, N Payne, John D. Isaacs, Coziana Ciurtin, H Noble, M Macoritto, A Parke, S Jelinsky, James N. Galloway, Ian C. Scott, Frederique Ponchel, Sarah Keidel, Denny Verbeeck, A Didierlaurent, MF McDermot, J Tarn, AT Virlan, T Lazarov, J Ellis, S Kaymakcalan, Anthony Rowe, Catharien M. U. Hilkens, G Altobelli, M Loza, P Jones, Ayako Wakatsuki Pedersen, Ian N. Bruce, Duncan Porter, A Cuza, D Ziemek, S Talbot, C Marshall, A Herath, D Finch, D Baker, Maya H Buch, Y Zhong, R Toward, Ludbrook, Mark Coles, Barnes, M Ho, M Page, J Casement, M Maciejewski, Claudio Carini, Sarah Brockbank, D Nguyen, H Tipney, A Filer, Christopher R. John, S Kelly, Andrew P. Cope, W Burny, M Curran, Catharina Lindholm, Benjamin A Fisher, Ray Harris, Jehan J. El-Jawhari, P Stocks, D Dastros-Pitel, Z Liu, Bdm Tom, Dennis Lendrem, Wayne Tsuji, F Stirling, J Worthington, Deborah P M Symmons, Matthew A. Sleeman, D Padhji, Fowzia Ibrahim, Smm Verstappen, P Budde, Ehrenstein, Marc C. Levesque, R Harry, B Allen, T Sabin, Michael Binks, Sally Hollis, Gerry Parker, S Lipsky, Georgina Thorborn, M Jenkins, A Hughes-Morley, Costantino Pitzalis, N Joseph, H Edwards, Jamie C. Sergeant, Paul Emery, H Ali, JA Butler, Liliane Fossati-Jimack, S Wright, Fiona Clarke, W Wu, Amy E. Anderson, Sharmila Rana, F Humby, F Hong, Myles Lewis, A Haynes, Katriona Goldmann, S Martins, CT Mela, S Hasan, David Scott, L Rowell, David Watson, Neil Gozzard, Karim Raza, Simon Read, M Hodge, Carl S. Goodyear, Farewell, George Davey Smith, Michele Bombardieri, Iain B. McInnes, C Larminie, G Simpson, N Ward, K Hicks, R Rao, Z Jia, FB Capdevila, A Long

Publikováno v: RA-MAP Consortium, Tom, B & Symmons, D 2018, ' Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data ', RMD Open, vol. 4, no. 2, pp. e000721 . https://doi.org/10.1136/rmdopen-2018-000721
RMD Open

ObjectivesTo identify predictors of remission and disease activity patterns in patients with rheumatoid arthritis (RA) using individual participant data (IPD) from clinical trials.MethodsPhase II and III clinical trials completed between 2002 and 201

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b48a096d68180fc5745f1e771c2710f
https://doi.org/10.1136/rmdopen-2018-000721

Elevated effector cell sensitivity to Treg-cell suppression that is not associated with reduced Th17-cell expression distinguishes HIV+asymptomatic subjects from progressors

Autor: Georgina Thorborn, Barry Peters, Heidi Ishohanni, Annapurna Vyakarnam, Laura Pomeroy

Publikováno v: European Journal of Immunology. 42:138-146

Suppression mediated by Treg cells is a balance between Treg-cell suppressive potency versus sensitivity of effector cells to Treg-cell suppression. We assessed if this balance, along with Treg-cell number relative to the Treg-cell counter-regulatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f96f883e4d179c4d8138e15668c0bdb8
https://doi.org/10.1002/eji.201141426