Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Georgina M. Platt"'
Publikováno v:
Journal of Biological Chemistry. 286:9713-9725
Cyclin/cyclin-dependent kinase (CDK) complexes are critical regulators of cellular proliferation. A complex network of regulatory mechanisms has evolved to control their activity, including activating and inactivating phosphorylation of the catalytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334b97f6ab74cc5637de24f281b52640
https://doi.org/10.1074/jbc.m110.173872
https://doi.org/10.1074/jbc.m110.173872
Autor:
Axel Knebel, Nick Morrice, Maria Emanuela Cuomo, Georgina M. Platt, Sibylle Mittnacht, Philip Cohen
Publikováno v:
Journal of Biological Chemistry. 280:35844-35858
Kaposi sarcoma-associated herpes virus (KSHV) encodes a D-like cyclin (K-cyclin) that is thought to contribute to the viral oncogenicity. K-cyclin activates cellular cyclin-dependent kinases (CDK) 4 and 6, generating enzymes with a substrate selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4b1a590a57f374f0faf3a1729c43c9
https://doi.org/10.1074/jbc.m503877200
https://doi.org/10.1074/jbc.m503877200
Autor:
Georgina M. Platt, Garrett, Sibylle Mittnacht, Juliet Richards, Paul Workman, SE Barrie, David C. Bedford, Anthea Hardcastle, E Eno-Amooquaye, Wynne Aherne
Publikováno v:
Analytical Biochemistry. 320:66-74
The tumor suppressor protein, pRb, regulates progression through the G1 phase of the cell cycle by its ability to bind to and regulate the activity of a variety of transcription factors. This function of pRb is disabled through its phosphorylation by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05dd7baf3d099e5129a3004ff77bbb8
https://doi.org/10.1016/s0003-2697(03)00349-x
https://doi.org/10.1016/s0003-2697(03)00349-x
Publikováno v:
Europe PubMed Central
Kaposi’s sarcoma-associated herpesvirus (KSHV/HHV-8) is the likely infectious cause of Kaposi’s sarcoma, primary effusion lymphoma, and some cases of multicentric Castleman’s disease. Its latent nuclear antigen (LANA) is expressed in the nuclei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f551380944ba6e9a96ae93f9b2fc22
https://doi.org/10.1128/jvi.73.12.9789-9795.1999
https://doi.org/10.1128/jvi.73.12.9789-9795.1999
Autor:
Clive Price, Georgina M. Platt
Publikováno v:
Yeast. 13:463-474
Treatment of Schizosaccharomyces pombe with the C5 DNA methyltransferase (C5Mtase) inhibitor 5-azacytidine (5-azaC) has previously been shown to induce G2 checkpoint-dependent cell cycle arrest. S. pombe strains defective in both the checkpoint contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc401a2681375cb898abab80a732164f
https://doi.org/10.1002/(sici)1097-0061(199704)13:5<463::aid-yea89>3.0.co
https://doi.org/10.1002/(sici)1097-0061(199704)13:5<463::aid-yea89>3.0.co
Autor:
Csaba Kiss, Georgina M. Platt, Thomas F. Schulz, Karin Mattsson, Guy Simpson, Elena Kashuba, George Klein, Laszlo Szekely
Publikováno v:
The Journal of general virology. 83(Pt 1)
LANA, the major latency-associated nuclear antigen of Kaposi’s sarcoma herpesvirus/human herpesvirus-8 (KSHV/HHV-8), binds RING3 protein, one of five human homologues of thefsh(female sterile homeotic) gene product ofDrosophila. In KSHV/HHV-8-infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5014acb08ba6df6bdf621cc4693084f7
https://pubmed.ncbi.nlm.nih.gov/11752715
https://pubmed.ncbi.nlm.nih.gov/11752715
Publikováno v:
Oncogene. 21(12)
The Kaposi's Sarcoma associated Herpes virus (KSHV) encodes two genes with the potential to affect the activity of the retinoblastoma protein (Rb). Open reading frame (orf) 72 encodes a D type cyclin (kcyc) that can elicit p16INK4a resistant cdk acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0f2e003ed978135719676832d3b3cf
https://pubmed.ncbi.nlm.nih.gov/11896614
https://pubmed.ncbi.nlm.nih.gov/11896614
Autor:
H Stoiber, R Sarid, Guy Simpson, Patrick S. Moore, Lucille Rainbow, Georgina M. Platt, C S Herrington, Thomas F. Schulz, Shou-Jiang Gao
Publikováno v:
Europe PubMed Central
Kaposi's sarcoma (KS)-associated herpesvirus or human herpesvirus 8 (KSHV/HHV8) is the likely cause of KS and primary effusion lymphomas or body cavity-based lymphomas (BCBLs). A latency-associated nuclear immunofluorescence antigen (LANA) (D. H. Ked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205982a0ea9521077ba07d69092d0b3d
https://pubmed.ncbi.nlm.nih.gov/9223481
https://pubmed.ncbi.nlm.nih.gov/9223481
Autor:
Julian Blagg, Stuart Wilson, Michelle D. Garrett, Simon R. Stockwell, G. Wynne Aherne, Georgina M. Platt, S. Elaine Barrie, Robert te Poele, Peter Sheldrake, Edward McDonald, Mathilde Venet, Laurent Rigoreau, Georgia Zoumpoulidou, Christelle Soudy, Paul Workman, Frédéric Elustondo, Sibylle Mittnacht
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 1, p e28568 (2012)
PLoS ONE, Vol 7, Iss 1, p e28568 (2012)
Human cancers often contain genetic alterations that disable G1/S checkpoint control and loss of this checkpoint is thought to critically contribute to cancer generation by permitting inappropriate proliferation and distorting fate-driven cell cycle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b0e6ca5d9089621cd9876c47f338a2
https://doi.org/10.1371/journal.pone.0028568
https://doi.org/10.1371/journal.pone.0028568
Publikováno v:
Virology. (2):257-266
The human herpesvirus 8 (HHV8/KSHV), along with certain other herpesviruses, encodes a gene with cyclin homology. Although the functional significance of the encoded cyclin is not clear at present, various lines of evidence propose a role for this cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfeec02b51759cae2c5965a8976e3f80