Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Georgina Hotter"'
Autor:
Selene Torrico, Georgina Hotter, Ángeles Muñoz, Priscila Calle, Miriam García, Esteban Poch, Soraya Játiva
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 178, Iss , Pp 117186- (2024)
In this study, we investigated if the therapeutic potential of peripheral blood mononuclear cell (PBMC) therapy in a murine model of ischemic AKI is related with the survival pattern of monocyte/macrophages in tissue. CD-1 mice were subjected to bila
Externí odkaz:
https://doaj.org/article/6c21c474b8fe499aa550a99aa30820bb
Autor:
Soraya Játiva, Selene Torrico, Priscila Calle, Ángeles Muñoz, Miriam García, Ana Belén Larque, Esteban Poch, Georgina Hotter
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 153, Iss , Pp 113415- (2022)
We propose the use of a peripheral blood mononuclear cell therapy based on cell NGAL release to be used in the clinical setting for acute kidney injury (AKI) and the derived fibrosis. First, we designed a procedure whereby PBMC overexpress NGAL and a
Externí odkaz:
https://doaj.org/article/fafbf376872e494baba485bb9212843b
Publikováno v:
Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-10 (2019)
Abstract Background Macrophage are specialized cells that contributes to the removal of detrimental contents via phagocytosis. Lipid accumulation in macrophages, whether from phagocytosis of dying cells or from circulating oxidized low-density lipopr
Externí odkaz:
https://doaj.org/article/c887ce55b40b4cdd8fafcaf13581f7b7
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15943 (2022)
The incidence of renal disease is gradually increasing worldwide, and this condition has become a major public health problem because it is a trigger for many other chronic diseases. Cell therapies using multipotent mesenchymal stromal cells, hematop
Externí odkaz:
https://doaj.org/article/5d36ff11f6cc4b93be5fda902909a682
Autor:
Soraya Játiva, Priscila Calle, Selene Torrico, Ángeles Muñoz, Miriam García, Ivet Martinez, Anna Sola, Georgina Hotter
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 329 (2022)
Macrophages have mechanisms for eliminating cholesterol from cells. If excess cholesterol is not eliminated from the macrophages, then transformation into a foam cell may occur. Foam cells are a hallmark of the atherosclerotic lesions that contribute
Externí odkaz:
https://doaj.org/article/6853bf19dc7044afb561711e4da14f19
Autor:
Anna Sola, Laura Saenz del Burgo, Jesús Ciriza, Rosa Maria Hernandez, Gorka Orive, Jorge Martin Cordero, Priscila Calle, Jose Luis Pedraz, Georgina Hotter
Publikováno v:
Drug Delivery, Vol 25, Iss 1, Pp 91-101 (2018)
Epithelial to mesenchymal transition (EMT) has emerged as a key process in the development of renal fibrosis. In fact, EMT-derived fibroblasts contribute to the progression of chronic renal disease. In addition, anti-inflammatory M2 macrophages have
Externí odkaz:
https://doaj.org/article/cb14b5afde2643799afb6e0d8a38e4bc
Infusion of Phagocytic Macrophages Overexpressing CPT1a Ameliorates Kidney Fibrosis in the UUO Model
Autor:
Priscila Calle, Soraya Játiva, Selene Torrico, Angeles Muñoz, Miriam García, Anna Sola, Dolors Serra, Paula Mera, Laura Herrero, Georgina Hotter
Publikováno v:
Cells, Vol 10, Iss 7, p 1650 (2021)
Phagocytosis is an inherent function of tissue macrophages for the removal of apoptotic cells and cellular debris during acute and chronic injury; however, the dynamics of this event during fibrosis development is unknown. We aim to prove that during
Externí odkaz:
https://doaj.org/article/d38e17a126bc4c7ba4196b7dff5f587c
Autor:
Roser Guiteras, Anna Sola, Maria Flaquer, Georgina Hotter, Joan Torras, Josep Maria Grinyó, Josep Maria Cruzado
Publikováno v:
Cellular Physiology and Biochemistry, Vol 42, Iss 5, Pp 1945-1960 (2017)
Background/Aims: Alternatively activated macrophages (AAM) have regenerative and anti-inflammatory characteristics. Here, we sought to evaluate whether AAM cell therapy reduces renal inflammation and fibrosis in the unilateral ureteral obstruction (U
Externí odkaz:
https://doaj.org/article/db4d45b7c76949338a6f7c555203b893
Autor:
Priscila Calle, Georgina Hotter
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8, p 2806 (2020)
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease globally. The primary initiating mechanism in DN is hyperglycemia-induced vascular dysfunction, but its progression is due to different pathological mechanisms, including oxida
Externí odkaz:
https://doaj.org/article/ce08962c002042f49601beab16523dd5
Autor:
Maria Teresa Torres-Salido, Mireia Sanchis, Cristina Solé, Teresa Moliné, Marta Vidal, Xavier Vidal, Anna Solà, Georgina Hotter, Josep Ordi-Ros, Josefina Cortés-Hernández
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4601 (2019)
At present, Lupus Nephritis (LN) is still awaiting a biomarker to better monitor disease activity, guide clinical treatment, and predict a patient’s long-term outcome. In the last decade, novel biomarkers have been identified to monitor the disease
Externí odkaz:
https://doaj.org/article/885e3993cea94768a2b0a32fdf1ea77a