Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Georgina H. Mason"'
Autor:
Yuan Chen, Georgina H. Mason, D. Oliver Scourfield, Alexander Greenshields-Watson, Tracey A. Haigh, Andrew K. Sewell, Heather M. Long, Awen M. Gallimore, Pierre Rizkallah, Bruce J. MacLachlan, Andrew Godkin
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112827- (2023)
Summary: CD4+ T cells recognize a broad range of peptide epitopes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which contribute to immune memory and limit COVID-19 disease. We demonstrate that the immunogenicity of SARS-CoV-2 pept
Externí odkaz:
https://doaj.org/article/89d593fdc3ac46c694db2226da7cae58
Autor:
Alexander Greenshields-Watson, Meriem Attaf, Bruce J. MacLachlan, Thomas Whalley, Cristina Rius, Aaron Wall, Angharad Lloyd, Hywel Hughes, Kathryn E. Strange, Georgina H. Mason, Andrea J. Schauenburg, Sarah L. Hulin-Curtis, James Geary, Yuan Chen, Sarah N. Lauder, Kathryn Smart, Dhanasekaran Vijaykrishna, Miguel L. Grau, Mikhail Shugay, Robert Andrews, Garry Dolton, Pierre J. Rizkallah, Awen M. Gallimore, Andrew K. Sewell, Andrew J. Godkin, David K. Cole
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107885- (2020)
Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by usi
Externí odkaz:
https://doaj.org/article/ac1881b0cc804226bb104e9cab830657
Autor:
Georgina H. Mason, David K. Cole, Frédéric Triebel, Awen Gallimore, Andrew James Godkin, Bruce J. MacLachlan, Alexander Greenshields-Watson
Publikováno v:
European Journal of Immunology
Immune checkpoint inhibitors (antibodies that block the T cell co‐inhibitory receptors PD‐1/PD‐L1 or CTLA‐4) have revolutionized the treatment of some forms of cancer. Importantly, combination approaches using drugs that target both pathways
Autor:
Andrew James Godkin, Alan L. Parker, Elise Moses, Rebecca J. Bayliss, Georgina H. Mason, Alicia Teijeira Crespo, Lorenzo Capitani, Awen Gallimore, James A. Davies, Stephanie E A Burnell
Publikováno v:
Immunology
Oncolytic viruses possess the ability to infect, replicate and lyse malignantly transformed tumour cells. This oncolytic activity amplifies the therapeutic advantage and induces a form of immunogenic cell death, characterized by increased CD8 + T‐c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8914e2f9ae1ff06e891522d1b1dce3ca
Autor:
Stephanie E A Burnell, Lorenzo Capitani, Bruce J MacLachlan, Georgina H Mason, Awen M Gallimore, Andrew Godkin
Publikováno v:
Immunotherapy advances. 2(1)
Despite three decades of research to its name and increasing interest in immunotherapies that target it, LAG-3 remains an elusive co-inhibitory receptor in comparison to the well-established PD-1 and CTLA-4. As such, LAG-3 targeting therapies have ye
Autor:
Robert Andrews, Sarah Nicol Lauder, Aaron Wall, Kathryn Smart, Bruce J. MacLachlan, Meriem Attaf, Pierre J. Rizkallah, Dhanasekaran Vijaykrishna, Yuan Chen, Georgina H. Mason, Andrew James Godkin, Garry Dolton, Mikhail Shugay, David K. Cole, Angharad Lloyd, Cristina Rius, Andrew K. Sewell, Miguel L. Grau, Andrea J. A. Schauenburg, Alexander Greenshields-Watson, Hywel Hughes, Kathryn E. Strange, Awen Gallimore, James Geary, Sarah Hulin-Curtis, Thomas Whalley
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107885-(2020)
Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75db8e6035331d3fe6e4c0c6bffbf5e9
Autor:
Andrea J. A. Schauenburg, Matthieu Besneux, Bruce J. MacLachlan, David K. Cole, Barbara Szomolay, Tim Elliott, Awen Gallimore, Garry Dolton, Andrew K. Sewell, Alexander Greenshields-Watson, Athanasios Papakyriakou, Pierre J. Rizkallah, Andrew James Godkin, Georgina H. Mason
Publikováno v:
The Journal of Biological Chemistry
CD4+ T-cells recognize peptide antigens, in the context of human leukocyte antigen (HLA) class II molecules (HLA-II), which through peptide-flanking residues (PFRs) can extend beyond the limits of the HLA binding. The role of the PFRs during antigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c61cec5cc9e6c62a6e657e5257cb79
https://eprints.soton.ac.uk/443721/
https://eprints.soton.ac.uk/443721/
Autor:
Alexander, Greenshields-Watson, Meriem, Attaf, Bruce J, MacLachlan, Thomas, Whalley, Cristina, Rius, Aaron, Wall, Angharad, Lloyd, Hywel, Hughes, Kathryn E, Strange, Georgina H, Mason, Andrea J, Schauenburg, Sarah L, Hulin-Curtis, James, Geary, Yuan, Chen, Sarah N, Lauder, Kathryn, Smart, Dhanasekaran, Vijaykrishna, Miguel L, Grau, Mikhail, Shugay, Robert, Andrews, Garry, Dolton, Pierre J, Rizkallah, Awen M, Gallimore, Andrew K, Sewell, Andrew J, Godkin, David K, Cole
Publikováno v:
Cell Reports
Summary T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by usin
Autor:
David K Cole, Anna Fuller, Andrew K Sewell, Pierre J Rizkallah, Valentina Bianchi, Andrea J Schauenburg, Georgina H Mason, Alexander Greenshields-Watson, Bruce J. MacLachlan
Publikováno v:
Journal of Visualized Experiments : JoVE
Human CD8+ cytotoxic T lymphocytes (CTLs) are known to play an important role in tumor control. In order to carry out this function, the cell surface-expressed T-cell receptor (TCR) must functionally recognize human leukocyte antigen (HLA)-restricted