Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Georgina C Fletcher"'
Autor:
Nerea Borreguero-Muñoz, Georgina C Fletcher, Mario Aguilar-Aragon, Ahmed Elbediwy, Zoé I Vincent-Mistiaen, Barry J Thompson
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000509 (2019)
The Hippo signalling pathway restricts cell proliferation in animal tissues by inhibiting Yes-associated protein (YAP or YAP1) and Transcriptional Activator with a PDZ domain (TAZ or WW-domain-containing transcriptional activator [WWTR1]), coactivato
Externí odkaz:
https://doaj.org/article/49700236fbce48088ee3945b33c7f241
Autor:
Clara Sidor, Nerea Borreguero-Munoz, Georgina C Fletcher, Ahmed Elbediwy, Oriane Guillermin, Barry J Thompson
Publikováno v:
eLife, Vol 8 (2019)
Mask family proteins were discovered in Drosophila to promote the activity of the transcriptional coactivator Yorkie (Yki), the sole fly homolog of mammalian YAP (YAP1) and TAZ (WWTR1). The molecular function of Mask, or its mammalian homologs Mask1
Externí odkaz:
https://doaj.org/article/c164dd5a41d141f28cc8676d26edc45c
Autor:
Mario Aguilar-Aragon, Ahmed Elbediwy, Valentina Foglizzo, Georgina C. Fletcher, Vivian S.W. Li, Barry J. Thompson
Publikováno v:
Cell Reports, Vol 22, Iss 7, Pp 1639-1646 (2018)
Summary: Epithelial cells are polarized along their apical-basal axis by the action of the small GTPase Cdc42, which is known to activate the aPKC kinase at the apical domain. However, loss of aPKC kinase activity was reported to have only mild effec
Externí odkaz:
https://doaj.org/article/eaf4599611d44c6c98975889ba8b5dd6
Autor:
Teresa T Bonello, Danfeng Cai, Georgina C Fletcher, Kyler Wiengartner, Victoria Pengilly, Kimberly S Lange, Zhe Liu, Jennifer Lippincott‐Schwartz, Jennifer M Kavran, Barry J Thompson
The Hippo pathway was originally discovered to control tissue growth in Drosophila and includes the Hippo kinase (Hpo; MST1/2 in mammals), scaffold protein Salvador (Sav; SAV1 in mammals) and the Warts kinase (Wts; LATS1/2 in mammals). The Hpo kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed60927d663b1406c463ef1b77686d22
Autor:
Mario Aguilar-Aragon, Teresa T Bonello, Barry J. Thompson, Georgina C. Fletcher, Graham P. Bell
Publikováno v:
EMBO Reports
Epithelial cells undergo cortical rounding at the onset of mitosis to enable spindle orientation in the plane of the epithelium. In cuboidal epithelia in culture, the adherens junction protein E‐cadherin recruits Pins/LGN/GPSM2 and Mud/NuMA to orie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8469db13203f163925af4b930210d0d7
https://doi.org/10.15252/embr.201949700
https://doi.org/10.15252/embr.201949700
Publikováno v:
Developmental Biology
Crumbs (Crb in Drosophila; CRB1-3 in mammals) is a transmembrane determinant of epithelial cell polarity and a regulator of Hippo signalling. Crb is normally localized to apical cell-cell contacts, just above adherens junctions, but how apical traffi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8344e070ce9e7fe2fea674b3c6d2c734
Autor:
Ahmed Elbediwy, Georgina C. Fletcher, Vivian S. W. Li, Mario Aguilar-Aragon, Valentina Foglizzo, Barry J. Thompson
Publikováno v:
Cell Reports
Cell Reports, Vol 22, Iss 7, Pp 1639-1646 (2018)
Cell Reports, Vol 22, Iss 7, Pp 1639-1646 (2018)
Summary Epithelial cells are polarized along their apical-basal axis by the action of the small GTPase Cdc42, which is known to activate the aPKC kinase at the apical domain. However, loss of aPKC kinase activity was reported to have only mild effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443a1bc047dd2d2cb13703083982e58f
https://doi.org/10.1016/j.celrep.2018.01.060
https://doi.org/10.1016/j.celrep.2018.01.060
Autor:
Georgina C. Fletcher, Zoé I. Vincent-Mistiaen, Barry J. Thompson, Ahmed Elbediwy, Mario Aguilar-Aragon, Nerea Borreguero-Munoz
Publikováno v:
PLoS Biology
PLoS Biology, Vol 17, Iss 10, p e3000509 (2019)
PLoS Biology, Vol 17, Iss 10, p e3000509 (2019)
The Hippo signalling pathway restricts cell proliferation in animal tissues by inhibiting Yes-associated protein (YAP or YAP1) and Transcriptional Activator with a PDZ domain (TAZ or WW-domain–containing transcriptional activator [WWTR1]), coactiva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875fc7c6836873984ab369b96599e22f
https://eprints.kingston.ac.uk/id/eprint/44230/1/Elbediwy-A-44230-VoR.pdf
https://eprints.kingston.ac.uk/id/eprint/44230/1/Elbediwy-A-44230-VoR.pdf