Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Georgina Bombau"'
Publikováno v:
Cells, Vol 11, Iss 13, p 1984 (2022)
Human pluripotent stem cells (hPSCs) have generated unprecedented interest in the scientific community, given their potential applications in regenerative medicine, disease modeling, toxicology and drug screening. However, hPSCs are prone to acquire
Externí odkaz:
https://doaj.org/article/c0201c774c3a4da882e5b04a499ac984
Autor:
Marco Straccia, Gerardo Garcia-Diaz Barriga, Phil Sanders, Georgina Bombau, Jordi Carrere, Pedro Belio Mairal, Ngoc-Nga Vinh, Sun Yung, Claire M Kelly, Clive N Svendsen, Paul J Kemp, Jamshid Arjomand, Ryan C Schoenfeld, Jordi Alberch, Nicholas D Allen, Anne E Rosser, Josep M Canals
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss , Pp - (2015)
A systematic characterization of the spatio-temporal gene expression during human neurodevelopment is essential to understand brain function in both physiological and pathological conditions. In recent years, stem cell technology has provided an in v
Externí odkaz:
https://doaj.org/article/a9286052aa584356b06eb800c8941e2b
Autor:
Andrés Miguez, Cinta Gomis, Cristina Vila, Marta Monguió-Tortajada, Sara Fernández-García, Georgina Bombau, Mireia Galofré, María García-Bravo, Phil Sanders, Helena Fernández-Medina, Blanca Poquet, Cristina Salado-Manzano, Santiago Roura, Jordi Alberch, José Carlos Segovia, Nicholas D. Allen, Francesc E. Borràs, Josep M. Canals
Huntington's disease (HD) is an incurable inherited brain disorder characterized by massive degeneration of striatal neurons, which correlates with abnormal accumulation of misfolded mutant huntingtin (mHTT) protein. Research on HD has been hampered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ef0006a11fa5cb7df1d1c747dada069
https://doi.org/10.21203/rs.3.rs-2154496/v1
https://doi.org/10.21203/rs.3.rs-2154496/v1
Autor:
Jordi Alberch, Phil Sanders, Jordi Carrere, Josep M. Canals, Joan Blasi, Javier G. Orlandi, Andrea Comella-Bolla, Marco Straccia, Nicholas D. Allen, María García-Bravo, Georgina Bombau, José C. Segovia, Andrés Miguez, Jordi Soriano, Mireia Galofré
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Molecular Neurobiology
Universidad de Barcelona
Molecular Neurobiology
Human pluripotent stem cells (hPSCs) are a powerful tool for modelling human development. In recent years, hPSCs have become central in cell-based therapies for neurodegenerative diseases given their potential to replace affected neurons. However, di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c561875e7de52beb4260fd1b5a68277b
https://doi.org/10.1007/s12035-020-01907-4
https://doi.org/10.1007/s12035-020-01907-4
Autor:
Holger Heyn, Phil Sanders, Gustavo Rodriguez-Esteban, Waseem Abbas, Anna Esteve-Codina, Mireia Galofré, Josep M. Canals, Andrea Honrubia, Petia Radeva, Georgina Bombau
Publikováno v:
B: Models for HD.
Huntington’s disease (HD) is a neurodegenerative disorder that primarily affects the medium spiny neurons (MSNs) of the striatum. Recent evidence indicates that there is a neurodevelopmental component to HD where MSN specification, maturation and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::110b3a184493a55ea7aee6df7c395da9
https://doi.org/10.1136/jnnp-2021-ehdn.21
https://doi.org/10.1136/jnnp-2021-ehdn.21
Autor:
Charlene Geater, Andrew D. Randall, Andrea Comella, Emma L Cope, Alis Hughes, Georgina Bombau, Marco Straccia, Christian Schnell, Philip Sanders, Nicholas D. Allen, Polina Yarova, Jon T. Brown, Natalie Connor-Robson, Vsevolod Telezhkin, Luned Badder, Jane M. Hancock, Belinda A.N. Thompson, Sun Yung, Paul J. Kemp, Josep M. Canals, Shona Joy
Publikováno v:
American Journal of Physiology-Cell Physiology. 310:C520-C541
Although numerous protocols have been developed for differentiation of neurons from a variety of pluripotent stem cells, most have concentrated on being able to specify effectively appropriate neuronal subtypes and few have been designed to enhance o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d68156237fcb066e6c304b7bd26821
https://doi.org/10.1152/ajpcell.00166.2015
https://doi.org/10.1152/ajpcell.00166.2015
Publikováno v:
Models for HD.
Huntington’s disease (HD) is a hereditary neurodegenerative disorder mainly characterized by striatal atrophy and degeneration of medium spiny neurons (MSNs). Although mouse models have provided a substantial amount of information about HD, they sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed686b45de271474c0e16c4afca2d68a
https://doi.org/10.1136/jnnp-2018-ehdn.67
https://doi.org/10.1136/jnnp-2018-ehdn.67
Autor:
Rafael Artuch, Bru Cormand, Francesc Sanmartí, Jordi Muchart, Georgina Bombau, Claudio Toma, Belén Pérez-Dueñas, Aida Ormazabal, Mercedes Serrano, Angels García-Cazorla
Publikováno v:
Journal of Inherited Metabolic Disease. 33:795-802
Several unrelated disorders can lead to 5-methyltetrahydrofolate (5MTHF) depletion in the cerobrospinal fluid (CSF), including primary genetic disorders in folate-related pathways or those causing defective transport across the blood-CSF barrier. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28934e87ba092c99f75ab47384915c7e
https://doi.org/10.1007/s10545-010-9196-1
https://doi.org/10.1007/s10545-010-9196-1
Autor:
Anne Elizabeth Rosser, Georgina Bombau, Josep M. Canals, Ryan C. Schoenfeld, Claire Kelly, Marco Straccia, Jordi Alberch, Pedro Belio Mairal, Jamshid Arjomand, Ngoc-Nga Vinh, Clive N. Svendsen, Paul J. Kemp, Phil Sanders, Nicholas D. Allen, Gerardo García-Díaz Barriga, Jordi Carrere, Sun Yung
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss, Pp-(2015)
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss, Pp-(2015)
A systematic characterization of the spatio-temporal gene expression during human neurodevelopment is essential to understand brain function in both physiological and pathological conditions. In recent years, stem cell technology has provided an in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e6a12280987ed48e0ac606e2ebf6f3
http://europepmc.org/articles/PMC4571731
http://europepmc.org/articles/PMC4571731