Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Georgina B. Gurrola"'
Autor:
Georgina B. Gurrola, E. Michelle Capes, Fernando Z. Zamudio, Lourival D. Possani, Héctor H. Valdivia
Publikováno v:
Pharmaceuticals, Vol 3, Iss 4, Pp 1093-1107 (2010)
Scorpion venoms are rich in ion channel-modifying peptides, which have proven to be invaluable probes of ion channel structure-function relationship. We previously isolated imperatoxin A (IpTxa), a 3.7 kDa peptide activator of Ca2+-release channels/r
Externí odkaz:
https://doaj.org/article/806209dee0ed4df49fd1afa4ae6bd663
Autor:
Omid Haji-Ghassemi, Yu Seby Chen, Kellie Woll, Georgina B. Gurrola, Carmen R. Valdivia, Wenxuan Cai, Songhua Li, Hector H. Valdivia, Filip Van Petegem
Publikováno v:
Science Advances. 9
Calcins are peptides from scorpion venom with the unique ability to cross cell membranes, gaining access to intracellular targets. Ryanodine Receptors (RyR) are intracellular ion channels that control release of Ca 2+ from the endoplasmic and sarcopl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59b93fe54b62e679f88a1c61584ad883
https://doi.org/10.1126/sciadv.adf4936
https://doi.org/10.1126/sciadv.adf4936
Autor:
Edson Norberto Carcamo-Noriega, I.A. García-Guerrero, Georgina B. Gurrola, Edmundo González-Santillán, Fernando Z. Zamudio, Lourival D. Possani, Froylan Gómez-Lagunas
Publikováno v:
Toxicon. 173:27-38
Every year in Mexico, around 300,000 people suffer from accidents related to scorpion stings. Among the scorpion species dangerous to human is Centruroides ornatus, whose venom characterization is described here. From this venom, a total of 114 compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511d4daa3c417cf0bf4dac19aa7b52d4
https://doi.org/10.1016/j.toxicon.2019.11.004
https://doi.org/10.1016/j.toxicon.2019.11.004
Autor:
R.L.L. Mendoza, J.I. Guijarro, Lourival D. Possani, Jimena I. Cid-Uribe, Muriel Delepierre, Georgina B. Gurrola, Fredy V. Coronas
Publikováno v:
Toxicon
Toxicon, Elsevier, 2019, 167, pp.184-191. ⟨10.1016/j.toxicon.2019.06.013⟩
Toxicon, 2019, 167, pp.184-191. ⟨10.1016/j.toxicon.2019.06.013⟩
Toxicon, Elsevier, 2019, 167, pp.184-191. ⟨10.1016/j.toxicon.2019.06.013⟩
Toxicon, 2019, 167, pp.184-191. ⟨10.1016/j.toxicon.2019.06.013⟩
International audience; A peptide (Cn29) from the venom of the scorpion Centruroides noxius (about 2% of the soluble venom) was purified and its primary and three-dimensional structures were determined. The peptide contains 27 amino acids with primar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48275c8ab58871322b4cc0efe019b942
https://doi.org/10.1016/j.toxicon.2019.06.013
https://doi.org/10.1016/j.toxicon.2019.06.013
Autor:
Agota Csoti, Rosby del Carmen Nájera Meza, Ferenc Bogár, Gabor Tajti, Tibor G. Szanto, Zoltan Varga, Georgina B. Gurrola, Gábor K. Tóth, Lourival D. Possani, Gyorgy Panyi
Publikováno v:
Biochemical Pharmacology. 199:115023
Kv1.3 K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad4636759b35ab3948a20ab34e7c310
https://doi.org/10.1016/j.bcp.2022.115023
https://doi.org/10.1016/j.bcp.2022.115023
Publikováno v:
Toxicon
Scorpions are well known for their dangerous stings that can result in severe consequences for human beings, including death. Neurotoxins present in their venoms are responsible for their toxicity. Due to their medical relevance, toxins have been the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5db7725f63b8c6046f45cae65d02518
https://doi.org/10.1016/j.toxicon.2014.11.233
https://doi.org/10.1016/j.toxicon.2014.11.233
Autor:
Yan-Ting Zhao, Héctor H. Valdivia, Carmen R. Valdivia, Georgina B. Gurrola, Jonathan J Hernandez
Publikováno v:
Science China. Life sciences
Ryanodine receptors (RyRs) are the calcium release channels of sarcoplasmic reticulum (SR) that provide the majority of calcium ions (Ca(2+)) necessary to induce contraction of cardiac and skeletal muscle cells. In their intracellular environment, Ry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716cb099932f8586cff2fcb923a7bd42
http://europepmc.org/articles/PMC6309702
http://europepmc.org/articles/PMC6309702
Autor:
Georgina B. Gurrola, Lourival D. Possani, Héctor H. Valdivia, Juana María Jiménez-Vargas, Verónica Quintero-Hernández
Publikováno v:
Toxicon. 76:328-342
The number and types of venom components that affect ion-channel function are reviewed. These are the most important venom components responsible for human intoxication, deserving medical attention, often requiring the use of specific anti-venoms. Sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818467e46d127760ab70d87158e0c848
https://doi.org/10.1016/j.toxicon.2013.07.012
https://doi.org/10.1016/j.toxicon.2013.07.012
Autor:
Georgina B. Gurrola, Patricia P. Powers, Carmen R. Valdivia, Richard L. Moss, Yan-Ting Zhao, José Jalife, Héctor H. Valdivia, B. Cicero Willis
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 112(13)
Current mechanisms of arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia (CPVT) require spontaneous Ca(2+) release via cardiac ryanodine receptor (RyR2) channels affected by gain-of-function mutations. Hence, hyperactive RyR2 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99af1eab5d0906a84400e5b4018b023
https://pubmed.ncbi.nlm.nih.gov/25775566
https://pubmed.ncbi.nlm.nih.gov/25775566
Autor:
Filippo Tempia, Tiziana Sacco, Lourival D. Possani, Enzo Wanke, Emanuele Schiavon, Rita Restano Cassulini, Georgina B. Gurrola
Publikováno v:
Journal of Biological Chemistry. 281:20326-20337
Resurgent currents are functionally crucial in sustaining the high frequency firing of cerebellar Purkinje neurons expressing Nav1.6 channels. β-Scorpion toxins, such as CssIV, induce a left shift in the voltage-dependent activation of Nav1.2 channe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7878edcc1f11c1d23ee1c8c06dec10dc
https://doi.org/10.1074/jbc.m600565200
https://doi.org/10.1074/jbc.m600565200