Effective CRISPR/Cas9-mediated correction of a Fanconi anemia defect by error-prone end joining or templated repair

Autor: Georgina Alexantya, Joey Riepsaame, Josephine C. Dorsman, Rob M. F. Wolthuis, Rahmen Bin Ali, Tim Harmsen, Yne de Vries, Ivo J. Huijbers, Hein te Riele, Saskia E. van Mil, Henri J van de Vrugt

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
van de Vrugt, H J, Harmsen, T, Riepsaame, J, Alexantya, G, van Mil, S E, de Vries, Y, Bin Ali, R, Huijbers, I J, Dorsman, J C, Wolthuis, R M F & te Riele, H 2019, ' Effective CRISPR/Cas9-mediated correction of a Fanconi anemia defect by error-prone end joining or templated repair ', Scientific Reports, vol. 9, no. 1, 768 . https://doi.org/10.1038/s41598-018-36506-w
Scientific Reports, 9(1):768. Nature Publishing Group

Fanconi anemia (FA) is a cancer predisposition syndrome characterized by congenital abnormalities, bone marrow failure, and hypersensitivity to aldehydes and crosslinking agents. For FA patients, gene editing holds promise for therapeutic application

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9baca3f6229ec55854905ae120850500
http://link.springer.com/article/10.1038/s41598-018-36506-w