The effect of combined β-lactoglobulin supplementation and resistance exercise training prior to limb immobilisation on muscle protein synthesis rates in healthy young adults: study protocol for a randomised controlled trial

Autor: Alix Hughes, Thomas Francis, Lindsey Marjoram, Jessica H. Rooney, Georgina Ellison-Hughes, Ross Pollock, Michael J. Curtis, Angela Cape, Mads Larsen, Bethan E. Phillips, Philip J. Atherton, Kenneth Smith, Oliver C. Witard

Publikováno v: Trials, Vol 24, Iss 1, Pp 1-11 (2023)

Abstract Background The decline in skeletal muscle mass experienced following a short-term period (days to weeks) of muscle disuse is mediated by impaired rates of muscle protein synthesis (MPS). Previous RCTs of exercise or nutrition prehabilitation

Externí odkaz: https://doaj.org/article/e7f89e2eaef94f89b8b81c7c4f1b35ea

Depletion of WFS1 compromises mitochondrial function in hiPSC-derived neuronal models of Wolfram syndrome

Autor: Malgorzata Zatyka, Tatiana R. Rosenstock, Congxin Sun, Adina M. Palhegyi, Georgina W. Hughes, Samuel Lara-Reyna, Dewi Astuti, Alessandro di Maio, Axel Sciauvaud, Miriam E. Korsgen, Vesna Stanulovic, Gamze Kocak, Malgorzata Rak, Sandra Pourtoy-Brasselet, Katherine Winter, Thiago Varga, Margot Jarrige, Hélène Polvèche, Joao Correia, Eva-Maria Frickel, Maarten Hoogenkamp, Douglas G. Ward, Laetitia Aubry, Timothy Barrett, Sovan Sarkar

Publikováno v: Stem Cell Reports. 18:1090-1106

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2eea67dac5d3e62e6cee12045d3442df
https://doi.org/10.1016/j.stemcr.2023.04.002

Analysis of Mitochondrial Dysfunction by Microplate Reader in hiPSC-Derived Neuronal Cell Models of Neurodegenerative Disorders

Autor: Tatiana R, Rosenstock, Congxin, Sun, Georgina Wynne, Hughes, Katherine, Winter, Sovan, Sarkar

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2549

Mitochondria are responsible for many vital pathways governing cellular homeostasis, including cellular energy management, heme biosynthesis, lipid metabolism, cellular proliferation and differentiation, cell cycle regulation, and cellular viability.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d94536f86de5795e4994bd1ee8752784
https://pubmed.ncbi.nlm.nih.gov/35347693

Process evaluation of the SImplification of Medications Prescribed to Long-tErm Care Residents (SIMPLER) cluster randomized controlled trial: a mixed methods study

Autor: Megan Corlis, Jan Van Emden, Esa Y. H. Chen, J. Simon Bell, Janet K. Sluggett, Tessa Caporale, Georgina A. Hughes, Choon Ean Ooi, Michelle Hogan

Publikováno v: International Journal of Environmental Research and Public Health
Volume 18
Issue 11
International Journal of Environmental Research and Public Health, Vol 18, Iss 5778, p 5778 (2021)

Complex medication regimens are highly prevalent, burdensome for residents and staff, and associated with poor health outcomes in residential aged care facilities (RACFs). The SIMPLER study was a non-blinded, matched-pair, cluster randomized controll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326e7b6b69ee6b9549069128db68cca9
https://hdl.handle.net/11541.2/148070

Simplifying Medication Regimens for People Receiving Community-Based Home Care Services: Outcomes of a Non-Randomized Pilot and Feasibility Study

Autor: Tessa Caporale, Janet K. Sluggett, Jan Van Emden, Manya Angley, Megan Corlis, J. Simon Bell, Choon Ean Ooi, Michelle Hogan, Georgina A. Hughes, Stephanie Gibson

Publikováno v: Clinical Interventions in Aging

Janet K Sluggett,1– 3 Choon Ean Ooi,1 Stephanie Gibson,1 Manya T Angley,4 Megan Corlis,3,5 Michelle E Hogan,3,5 Tessa Caporale,5 Georgina A Hughes,1,4 Jan Van Emden,3,5 J Simon Bell1,3,6 1Centre for Medicine Use and Safety, Faculty of Pharmacy and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5d7d77df73dabb618ce6856429e454
https://www.dovepress.com/simplifying-medication-regimens-for-people-receiving-community-based-h-peer-reviewed-article-CIA