Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva‐Derived Endothelial Cells

Autor: Gonzalo Sánchez‐Duffhues, Eleanor Williams, Pascal Benderitter, Valeria Orlova, Michiel vanWijhe, Amaya Garcia de Vinuesa, Georgina Kerr, Josselin Caradec, Kirsten Lodder, Hetty C. deBoer, Marie‐José Goumans, Elisabeth M W Eekhoff, Antonio Morales‐Piga, Javier Bachiller‐Corral, Pieter Koolwijk, Alex N. Bullock, Jan Hoflack, Peter tenDijke

Publikováno v: JBMR Plus, Vol 3, Iss 11, Pp n/a-n/a (2019)

ABSTRACT Fibrodysplasia ossificans progressiva (FOP) is an extremely rare congenital form of heterotopic ossification (HO), caused by heterozygous mutations in the activin A type I receptor (ACVR1), that encodes the bone morphogenetic protein (BMP) t

Externí odkaz: https://doaj.org/article/0a8805072273478a99c58ea64ddffeb9

Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19

Autor: Christos P Kotanidis, Cheng Xie, Donna Alexander, Jonathan C L Rodrigues, Katie Burnham, Alexander Mentzer, Daniel O’Connor, Julian Knight, Muhammad Siddique, Helen Lockstone, Sheena Thomas, Rafail Kotronias, Evangelos K Oikonomou, Ileana Badi, Maria Lyasheva, Cheerag Shirodaria, Sheila F Lumley, Bede Constantinides, Nicholas Sanderson, Gillian Rodger, Kevin K Chau, Archie Lodge, Maria Tsakok, Fergus Gleeson, David Adlam, Praveen Rao, Das Indrajeet, Aparna Deshpande, Amrita Bajaj, Benjamin J Hudson, Vivek Srivastava, Shakil Farid, George Krasopoulos, Rana Sayeed, Ling-Pei Ho, Stefan Neubauer, David E Newby, Keith M Channon, John Deanfield, Charalambos Antoniades, David J Ahern, Zhichao Ai, Mark Ainsworth, Chris Allan, Alice Allcock, Brian Angus, M Azim Ansari, Carolina Arancibia-Cárcamo, Dominik Aschenbrenner, Moustafa Attar, J Kenneth Baillie, Eleanor Barnes, Rachael Bashford-Rogers, Archana Bashyal, Sally Beer, Georgina Berridge, Amy Beveridge, Sagida Bibi, Tihana Bicanic, Luke Blackwell, Paul Bowness, Andrew Brent, Andrew Brown, John Broxholme, David Buck, Helen Byrne, Susana Camara, Ivan Candido Ferreira, Philip Charles, Wentao Chen, Yi-Ling Chen, Amanda Chong, Elizabeth Clutterbuck, Mark Coles, Christopher Conlon, Richard Cornall, Adam Cribbs, Fabiola Curion, Emma Davenport, Neil Davidson, Simon Davis, Calliope Dendrou, Julie Dequaire, Lea Dib, James Docker, Christina Dold, Tao Dong, Damien Downes, Hal Drakesmith, Susanna Dunachie, David Duncan, Chris Eijsbouts, Robert Esnouf, Alexis Espinosa, Rachel Etherington, Benjamin Fairfax, Rory Fairhead, Hai Fang, Shayan Fassih, Sally Felle, Maria Fernandez Mendoza, Ricardo Ferreira, Roman Fischer, Thomas Foord, Aden Forrow, John Frater, Anastasia Fries, Veronica Gallardo Sanchez, Lucy Garner, Clementine Geeves, Dominique Georgiou, Leila Godfrey, Tanya Golubchik, Maria Gomez Vazquez, Angie Green, Hong Harper, Heather Harrington, Raphael Heilig, Svenja Hester, Jennifer Hill, Charles Hinds, Clare Hird, Renee Hoekzema, Benjamin Hollis, Jim Hughes, Paula Hutton, Matthew Jackson-Wood, Ashwin Jainarayanan, Anna James-Bott, Kathrin Jansen, Katie Jeffery, Elizabeth Jones, Luke Jostins, Georgina Kerr, David Kim, Paul Klenerman, Vinod Kumar, Piyush Kumar Sharma, Prathiba Kurupati, Andrew Kwok, Angela Lee, Aline Linder, Teresa Lockett, Lorne Lonie, Maria Lopopolo, Martyna Lukoseviciute, Jian Luo, Spyridoula Marinou, Brian Marsden, Jose Martinez, Philippa Matthews, Michalina Mazurczyk, Simon McGowan, Stuart McKechnie, Adam Mead, Yuxin Mi, Claudia Monaco, Ruddy Montadon, Giorgio Napolitani, Isar Nassiri, Alex Novak, Darragh O'Brien, Daniel O'Connor, Denise O'Donnell, Graham Ogg, Lauren Overend, Inhye Park, Ian Pavord, Yanchun Peng, Frank Penkava, Mariana Pereira Pinho, Elena Perez, Andrew Pollard, Fiona Powrie, Bethan Psaila, T Phuong Quan, Emmanouela Repapi, Santiago Revale, Laura Silva-Reyes, Jean-Baptiste Richard, Charlotte Rich-Griffin, Thomas Ritter, Christine Rollier, Matthew Rowland, Fabian Ruehle, Mariolina Salio, Stephen Nicholas Sansom, Raphael Sanches Peres, Alberto Santos Delgado, Tatjana Sauka-Spengler, Ron Schwessinger, Giuseppe Scozzafava, Gavin Screaton, Anna Seigal, Malcolm Semple, Martin Sergeant, Christina Simoglou Karali, David Sims, Donal Skelly, Hubert Slawinski, Alberto Sobrinodiaz, Nikolaos Sousos, Lizzie Stafford, Lisa Stockdale, Marie Strickland, Otto Sumray, Bo Sun, Chelsea Taylor, Stephen Taylor, Adan Taylor, Supat Thongjuea, Hannah Thraves, John Todd, Adriana Tomic, Orion Tong, Amy Trebes, Dominik Trzupek, Felicia Anna Tucci, Lance Turtle, Irina Udalova, Holm Uhlig, Erinke van Grinsven, Iolanda Vendrell, Marije Verheul, Alexandru Voda, Guanlin Wang, Lihui Wang, Dapeng Wang, Peter Watkinson, Robert Watson, Michael Weinberger, Justin Whalley, Lorna Witty, Katherine Wray, Luzheng Xue, Hing Yuen Yeung, Zixi Yin, Rebecca Young, Jonathan Youngs, Ping Zhang, Yasemin-Xiomara Zurke, Adrian Banning, Alexios Antonopoulos, Andrew Kelion, Attila Kardos, Benjamin Hudson, Bon-Kwon Koo, Christos Kotanidis, Ciara Mahon, Colin Berry, David Newby, Derek Connolly, Diane Scaletta, Ed Nicol, Elisa McAlindon, Evangelos Oikonomou, Francesca Pugliese, Gianluca Pontone, Giulia Benedetti, Guo-Wei He, Henry West, Hidekazu Kondo, Imre Benedek, Intrajeet Das, John Graby, John Greenwood, Jonathan Rodrigues, Junbo Ge, Keith Channon, Larissa Fabritz, Li-Juan Fan, Lucy Kingham, Marco Guglielmo, Matthias Schmitt, Meinrad Beer, Michelle Anderson, Milind Desai, Mohamed Marwan, Naohiko Takahashi, Nehal Mehta, Neng Dai, Nicholas Screaton, Nikant Sabharwal, Pál Maurovich-Horvat, Rajesh Kharbanda, Rebecca Preston, Richard Wood, Ron Blankstein, Ronak Rajani, Saeed Mirsadraee, Shahzad Munir, Steffen Klömpken, Steffen Petersen, Stephan Achenbach, Susan Anthony, Sze Mak, Tarun Mittal, Theodora Benedek, Vinoda Sharma, Wen-Hua Lin

Publikováno v: The Lancet. Digital Health, 4, 10, pp. e705-e716
The Lancet. Digital Health, 4, e705-e716

Contains fulltext : 286832.pdf (Publisher’s version ) (Open Access) BACKGROUND: Direct evaluation of vascular inflammation in patients with COVID-19 would facilitate more efficient trials of new treatments and identify patients at risk of long-term

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667e9c3752db2a7c11d82a56de81ce50
https://ora.ox.ac.uk/objects/uuid:eae65b13-07e0-4f03-8fff-f05e44fa1bf9

A new class of small molecule inhibitor of BMP signaling.

Autor: Caroline E Sanvitale, Georgina Kerr, Apirat Chaikuad, Marie-Christine Ramel, Agustin H Mohedas, Sabine Reichert, You Wang, James T Triffitt, Gregory D Cuny, Paul B Yu, Caroline S Hill, Alex N Bullock

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e62721 (2013)

Growth factor signaling pathways are tightly regulated by phosphorylation and include many important kinase targets of interest for drug discovery. Small molecule inhibitors of the bone morphogenetic protein (BMP) receptor kinase ALK2 (ACVR1) are nee

Externí odkaz: https://doaj.org/article/4f1ebb09c53a433cadc42dc14a4de370

Broad and strong memory CD4

Autor: Yanchun, Peng, Alexander J, Mentzer, Guihai, Liu, Xuan, Yao, Zixi, Yin, Danning, Dong, Wanwisa, Dejnirattisai, Timothy, Rostron, Piyada, Supasa, Chang, Liu, César, López-Camacho, Jose, Slon-Campos, Yuguang, Zhao, David I, Stuart, Guido C, Paesen, Jonathan M, Grimes, Alfred A, Antson, Oliver W, Bayfield, Dorothy E D P, Hawkins, De-Sheng, Ker, Beibei, Wang, Lance, Turtle, Krishanthi, Subramaniam, Paul, Thomson, Ping, Zhang, Christina, Dold, Jeremy, Ratcliff, Peter, Simmonds, Thushan, de Silva, Paul, Sopp, Dannielle, Wellington, Ushani, Rajapaksa, Yi-Ling, Chen, Mariolina, Salio, Giorgio, Napolitani, Wayne, Paes, Persephone, Borrow, Benedikt M, Kessler, Jeremy W, Fry, Nikolai F, Schwabe, Malcolm G, Semple, J Kenneth, Baillie, Shona C, Moore, Peter J M, Openshaw, M Azim, Ansari, Susanna, Dunachie, Eleanor, Barnes, John, Frater, Georgina, Kerr, Philip, Goulder, Teresa, Lockett, Robert, Levin, Yonghong, Zhang, Ronghua, Jing, Ling-Pei, Ho, Richard J, Cornall, Christopher P, Conlon, Paul, Klenerman, Gavin R, Screaton, Juthathip, Mongkolsapaya, Andrew, McMichael, Julian C, Knight, Graham, Ogg

Publikováno v: Nature immunology. 21(11)

The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery from COVID-19 (28 with mild disease and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a9297136ff57002dc5d66f91bec21ad
https://pubmed.ncbi.nlm.nih.gov/32895541

Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva-Derived Endothelial Cells

Autor: Peter ten Dijke, Pascal Andre Rene Benderitter, Gonzalo Sanchez-Duffhues, Alex N. Bullock, Amaya García de Vinuesa, Hetty C. de Boer, Valeria V. Orlova, Josselin Caradec, Elisabeth M.W. Eekhoff, Jan Hoflack, Javier Bachiller-Corral, Eleanor Williams, Georgina Kerr, Marie-José Goumans, Kirsten Lodder, Pieter Koolwijk, Michiel H. van Wijhe, Antonio Morales-Piga

Publikováno v: JBMR Plus, Vol 3, Iss 11, Pp n/a-n/a (2019)
JBMR Plus, 3(11):e10230. Wiley-Blackwell Publishing Ltd
Repisalud
Instituto de Salud Carlos III (ISCIII)
Sánchez-Duffhues, G, Williams, E, Benderitter, P, Orlova, V, van Wijhe, M, Garcia de Vinuesa, A, Kerr, G, Caradec, J, Lodder, K, de Boer, H C, Goumans, M-J, Eekhoff, E M W, Morales-Piga, A, Bachiller-Corral, J, Koolwijk, P, Bullock, A N, Hoflack, J & Ten Dijke, P 2019, ' Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva-Derived Endothelial Cells ', JBMR Plus, vol. 3, no. 11, e10230 . https://doi.org/10.1002/jbm4.10230
JBMR Plus

Fibrodysplasia ossificans progressiva (FOP) is an extremely rare congenital form of heterotopic ossification (HO), caused by heterozygous mutations in the activin A type I receptor (ACVR1), that encodes the bone morphogenetic protein (BMP) type I rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c9c996c8b5f78e8400fed539edddb3
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85083551715&origin=inward