Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Georgiana Nitulescu"'
Autor:
Octavian Tudorel Olaru, George Mihai Nitulescu, Andreea Miruna Codreanu, Valentina-Andreea Calmuc, Luanne Venables, Maryna van de Venter, Cerasela Elena Gird, Cosmina-Gabriela Duta-Bratu, Georgiana Nitulescu
Publikováno v:
Plants, Vol 13, Iss 10, p 1405 (2024)
A promising strategy for combating bacterial infections involves the development of agents that disarm the virulence factors of pathogenic bacteria, thereby reducing their pathogenicity without inducing direct lethality. Sortase A, a crucial enzyme r
Externí odkaz:
https://doaj.org/article/aa8ab52c4b1c4bff971fe07cee54acec
Autor:
Corina Andrei, Dragos Paul Mihai, Georgiana Nitulescu, Anca Ungurianu, Denisa Marilena Margina, George Mihai Nitulescu, Octavian Tudorel Olaru, Radu Mihai Busca, Anca Zanfirescu
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1563 (2023)
Osteoarthritis is characterized by progressive articular cartilage degradation, subchondral bone changes, and synovial inflammation, and affects various joints, causing pain and disability. Current osteoarthritis therapies, primarily focused on pain
Externí odkaz:
https://doaj.org/article/5294a96fb3a6425c9ae54eb18d75cc87
Publikováno v:
Cosmetics, Vol 10, Iss 4, p 101 (2023)
Sunscreens reduce the occurrence risk of skin disorders such as sunburn, skin aging, and cancer through their ability to absorb, reflect, and scatter ultraviolet (UV) radiation. This review provides an overview of UV filters as active ingredients of
Externí odkaz:
https://doaj.org/article/0777983d73ee4ccca1adb53d323ef5e9
Autor:
George Mihai Nitulescu, Gheorghe Stancov, Oana Cristina Seremet, Georgiana Nitulescu, Dragos Paul Mihai, Cosmina Gabriela Duta-Bratu, Stefania Felicia Barbuceanu, Octavian Tudorel Olaru
Publikováno v:
Molecules, Vol 28, Iss 14, p 5359 (2023)
The altered activation or overexpression of protein kinases (PKs) is a major subject of research in oncology and their inhibition using small molecules, protein kinases inhibitors (PKI) is the best available option for the cure of cancer. The pyrazol
Externí odkaz:
https://doaj.org/article/780606446a7b464196f22eb220eda6ff
Autor:
Georgiana Nitulescu, Dragos Paul Mihai, Anca Zanfirescu, Miruna Silvia Stan, Daniela Gradinaru, George Mihai Nitulescu
Publikováno v:
Life, Vol 12, Iss 12, p 2114 (2022)
Bacterial virulence factors are mediating bacterial pathogenesis and infectivity. Collagenases are virulence factors secreted by several bacterial stains, such as Clostridium, Bacillus, Vibrio and Pseudomonas. These enzymes are among the most efficie
Externí odkaz:
https://doaj.org/article/5a875e1aaf564d4a9bb0d01c8257db19
Publikováno v:
Pharmaceuticals, Vol 15, Iss 1, p 38 (2021)
Chronic pain determines a substantial burden on individuals, employers, healthcare systems, and society. Most of the affected patients report dissatisfaction with currently available treatments. There are only a few and poor therapeutic options—som
Externí odkaz:
https://doaj.org/article/b310b87d762644a589af82b58f66911e
Autor:
Georgiana Nitulescu, George Mihai Nitulescu, Anca Zanfirescu, Dragos Paul Mihai, Daniela Gradinaru
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 62 (2021)
The pharmacological inhibition of the bacterial collagenases (BC) enzymes is considered a promising strategy to block the virulence of the bacteria without targeting the selection mechanism leading to drug resistance. The chemical structures of the C
Externí odkaz:
https://doaj.org/article/0080d70437da4bf3aaeec2d106d94ad1
Autor:
Galyna Volynets, Hanna Vyshniakova, Georgiana Nitulescu, George Mihai Nitulescu, Anca Ungurianu, Denisa Margina, Olena Moshynets, Volodymyr Bdzhola, Ihor Koleiev, Olga Iungin, Sergiy Tarnavskiy, Sergiy Yarmoluk
Publikováno v:
Molecules, Vol 26, Iss 23, p 7095 (2021)
Staphylococcus aureus (S. aureus) is a causative agent of many hospital- and community-acquired infections with the tendency to develop resistance to all known antibiotics. Therefore, the development of novel antistaphylococcal agents is of urgent ne
Externí odkaz:
https://doaj.org/article/a58e16e59b4044fabbf36a93d5e2f425
Autor:
Georgiana Nitulescu, Denisa Margina, Anca Zanfirescu, Octavian Tudorel Olaru, George Mihai Nitulescu
Publikováno v:
Pharmaceuticals, Vol 14, Iss 5, p 415 (2021)
Increasingly ineffective antibiotics and rapid spread of multi- and pan-resistant bacteria represent a global health threat; hence, the need of developing new antimicrobial medicines. A first step in this direction is identifying new molecular target
Externí odkaz:
https://doaj.org/article/699558e1e38d4beb9a57f468d7b88c02
Autor:
Anca Zanfirescu, Georgiana Nitulescu, Gheorghe Stancov, Denise Radulescu, Cosmin Trif, George Mihai Nitulescu, Simona Negres, Octavian Tudorel Olaru
Publikováno v:
Scientia Pharmaceutica, Vol 88, Iss 2, p 26 (2020)
Medicinal plants hold a significant place as alternative treatments available for inflammatory diseases, with many phytoconstituents being frequently tested in vitro for their biological activities. In the current study, we investigated the in vivo a
Externí odkaz:
https://doaj.org/article/c956f2eeb8be4b3c9449ecb0c0b9e16a