Discovery of the First-in-Class Inhibitors of Hypoxia Up-Regulated Protein 1 (HYOU1) Suppressing Pathogenic Fibroblast Activation.

Autor: Papadopoulou D; Institute for Bioinnovation, Biomedical Sciences Research Center 'Alexander Fleming', 16672, Vari, Greece., Mavrikaki V; Institute for Bioinnovation, Biomedical Sciences Research Center 'Alexander Fleming', Vari, 16672, Athens, Greece.; Department of Chemistry, Laboratory of Organic Chemistry, National and Kapodistrian University of Athens, 15784, Athens, Greece., Charalampous F; Institute for Bioinnovation, Biomedical Sciences Research Center 'Alexander Fleming', 16672, Vari, Greece., Tzaferis C; Institute for Bioinnovation, Biomedical Sciences Research Center 'Alexander Fleming', 16672, Vari, Greece., Samiotaki M; Institute for Bioinnovation, Biomedical Sciences Research Center 'Alexander Fleming', 16672, Vari, Greece., Papavasileiou KD; Department of ChemoInformatics, Novamechanics Ltd., 1070, Nicosia, Cyprus.; Department of Chemoinformatics, Novamechanics MIKE, 18545, Piraeus, Greece.; Division of Data Driven Innovation, Entelos Institute, 6059, Larnaca, Cyprus., Afantitis A; Department of ChemoInformatics, Novamechanics Ltd., 1070, Nicosia, Cyprus.; Department of Chemoinformatics, Novamechanics MIKE, 18545, Piraeus, Greece.; Division of Data Driven Innovation, Entelos Institute, 6059, Larnaca, Cyprus., Karagianni N; Biomedcode Hellas S.A., 16672, Vari, Greece., Denis MC; Biomedcode Hellas S.A., 16672, Vari, Greece., Sanchez J; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, NG7 2UH, Nottingham, U.K.; Centre of Membrane Proteins and Receptors, Universities of Birmingham and Nottingham, NG2 7AG, Midlands, U.K., Lane JR; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, NG7 2UH, Nottingham, U.K.; Centre of Membrane Proteins and Receptors, Universities of Birmingham and Nottingham, NG2 7AG, Midlands, U.K., Faidon Brotzakis Z; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, U.K.; Institute for Bioinnovation, Biomedical Sciences Research Center 'Alexander Fleming', 16672, Vari, Greece., Skretas G; Institute for Bioinnovation, Biomedical Sciences Research Center 'Alexander Fleming', 16672, Vari, Greece.; Institute of Chemical Biology, National Hellenic Research Foundation, 11635, Athens, Greece., Georgiadis D; Department of Chemistry, Laboratory of Organic Chemistry, National and Kapodistrian University of Athens, 15784, Athens, Greece., Matralis AN; Institute for Bioinnovation, Biomedical Sciences Research Center 'Alexander Fleming', 16672, Vari, Greece., Kollias G; Institute for Bioinnovation, Biomedical Sciences Research Center 'Alexander Fleming', 16672, Vari, Greece.; Department of Physiology, Medical School, National and Kapodistrian University of Athens, 11527, Athens, Greece.; Research Institute of New Biotechnologies and Precision Medicine, National and Kapodistrian University of Athens, 11527, Athens, Greece.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Apr 02; Vol. 63 (14), pp. e202319157. Date of Electronic Publication: 2024 Feb 26.

ERAP2 Inhibition Induces Cell‐Surface Presentation by MOLT‐4 Leukemia Cancer Cells of Many Novel and Potentially Antigenic Peptides

Autor: Temponeras, I. Stamatakis, G. Samiotaki, M. Georgiadis, D. Pratsinis, H. Panayotou, G. Stratikos, E.

Recent studies have linked the activity of ER aminopeptidase 2 (ERAP2) to increased efficacy of immune‐checkpoint inhibitor cancer immunotherapy, suggesting that pharmacological inhibition of ERAP2 could have important therapeutic implications. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::45d6514d21a1c5800b47026212e1d8a5
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2980539

Diastereoselective Synthesis of Phosphinic Dipeptide Isosteres: Domino Chirality Transfer during a Stereocontrolled P-Michael Reaction.

Autor: Lelis A; Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15784 Athens, Greece., Skoulikas N; Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15784 Athens, Greece., Papathanasopoulou M; Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15784 Athens, Greece., Voreakos K; Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15784 Athens, Greece., Georgiadis D; Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15784 Athens, Greece.

Publikováno v: Organic letters [Org Lett] 2023 Sep 15; Vol. 25 (36), pp. 6623-6627. Date of Electronic Publication: 2023 Sep 05.

Cruciate paralysis or man-in-the-barrel syndrome? Report of a case of Brachial Diplegia.

Autor: Georgiadis, D¹, Schulte-Mattler, W. J¹

Publikováno v: Acta Neurologica Scandinavica. Apr2002, Vol. 105 Issue 4, p337-340. 4p. 3 Graphs.

A Reliable Enantioselective Route to Mono-Protected N1-Cbz Piperazic Acid Building Block

Autor: Papadaki, E. Georgiadis, D. Tsakos, M.

The chiral N1-Cbz, N2-H derivative of the piperazic acid monomer is a valuable building block in the total synthesis of natural products, comprising this nonproteinogenic amino acid. In that context, we wish to report an improved synthetic protocol f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::651ba16043698790a21e7529dd7cd427
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3020601