Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Georgia R. Frost"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Described as the “proteasome of the membrane” or the “scissors in the membrane,” γ-secretase has notoriously complicated biology, and even after decades of research, the full extent of its regulatory mechanism remains unclear. γ-Secretase i
Externí odkaz:
https://doaj.org/article/5217a41ed0cf4fe686aa2f27a9ac2a4d
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Alzheimer’s disease (AD) is marked by the presence of amyloid beta (Aβ) plaques, neurofibrillary tangles (NFT), neuronal death and synaptic loss, and inflammation in the brain. AD research has, in large part, been dedicated to the understanding of
Externí odkaz:
https://doaj.org/article/c6ca73c705f540388ed1a26fd2448012
Autor:
Georgia R. Frost, Yue-Ming Li
Publikováno v:
Open Biology, Vol 7, Iss 12 (2017)
Alzheimer's disease (AD) is marked by the presence of extracellular amyloid beta (Aβ) plaques, intracellular neurofibrillary tangles (NFTs) and gliosis, activated glial cells, in the brain. It is thought that Aβ plaques trigger NFT formation, neuro
Externí odkaz:
https://doaj.org/article/32d173c1db1f4805b6b9481d5afb58a4
Autor:
Courtney Alexander, Thomas Li, Yorito Hattori, Danica Chiu, Georgia R. Frost, Lauren Jonas, Chenge Liu, Corey J. Anderson, Eitan Wong, Laibaik Park, Costantino Iadecola, Yue-Ming Li
Publikováno v:
Mol Psychiatry
Hypoxic-ischemic injury has been linked with increased risk for developing Alzheimer’s disease (AD). The underlying mechanism of this association is poorly understood. Here, we report distinct roles for hypoxia-inducible factor-1α (Hif-1α) in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa4223a3233465412672a58fc73136f
https://doi.org/10.1038/s41380-022-01676-7
https://doi.org/10.1038/s41380-022-01676-7
Autor:
Merav Antman-Passig, Eitan Wong, Georgia R. Frost, Christian Cupo, Janki Shah, Albert Agustinus, Ziyu Chen, Chiara Mancinelli, Maikel Kamel, Thomas Li, Lauren A. Jonas, Yue-Ming Li, Daniel A. Heller
Publikováno v:
ACS Nano
Amyloid-beta (Aβ) deposition occurs in the early stages of Alzheimer’s disease (AD), but the early detection of Aβ is a persistent challenge. Herein, we engineered a near-infrared optical nanosensor capable of detecting Aβ intracellularly in liv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23057c3c9c35a6898c952c17e0f7ba74
https://pubmed.ncbi.nlm.nih.gov/35420796
https://pubmed.ncbi.nlm.nih.gov/35420796
Autor:
Yungui Zhou, Shiaoching Gong, John Hardy, Qingyun Li, Linas Mazutis, Li Fan, Yue Qiu, Pearly Ye, Dennis W. Dickson, Tara E. Tracy, Xiang Niu, Lay Kodama, Michael DeTure, Bin Zhang, Subhash C. Sinha, Wenjie Luo, Xueting Wang, Xueqiao Jiang, Lei Xie, Guoqiang Yu, Fei Wang, Li Gan, Zuolin Cheng, Georgia R. Frost, Maria Telpoukhovskaia, Rose Horowitz, John Q. Trajnowski, Man Ying Wong, Fuying Gao, Giovanni Coppola, Yaqiao Li, Virginia M.-Y. Lee, Faten A. Sayed, Lu Zhou, Hansruedi Mathys, Joe C. Udeochu, David Le, Gillian K. Carling, Matthew Brendel, Minghui Wang
Publikováno v:
Sci Transl Med
The hemizygous R47H variant of Triggering receptor expressed on myeloid cells 2 (TREM2), a microglia-specific gene in the brain, increases risk for late-onset Alzheimer’s disease (AD). Using transcriptomic analysis of single-nuclei from brain tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7bfaa5135ff0c66a29779f068ec0946
https://doi.org/10.1126/scitranslmed.abe3947
https://doi.org/10.1126/scitranslmed.abe3947
Autor:
George P. Liao, Thomas Li, Kelly E. Henry, Veronica L. Nagle, Blesida Punzalan, Xianzhong Wu, Jason S. Lewis, Lukas M. Carter, Naga Vara Kishore Pillarsetty, Pengju Nie, Teja Kalidindi, Georgia R. Frost, Yue-Ming Li
Publikováno v:
Clin Cancer Res
Purpose: Abnormal Notch signaling promotes cancer cell growth and tumor progression in various cancers. Targeting γ-secretase, a pivotal regulator in the Notch pathway, has yielded numerous γ-secretase inhibitors (GSIs) for clinical investigation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd8701089a39acff7d3d4e980642e68
https://pubmed.ncbi.nlm.nih.gov/34475100
https://pubmed.ncbi.nlm.nih.gov/34475100
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience
Described as the “proteasome of the membrane” or the “scissors in the membrane,” γ-secretase has notoriously complicated biology, and even after decades of research, the full extent of its regulatory mechanism remains unclear. γ-Secretase i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb01cf961db08433ccbed24febabcb5b
https://www.frontiersin.org/articles/10.3389/fnagi.2020.614690/full
https://www.frontiersin.org/articles/10.3389/fnagi.2020.614690/full
Autor:
Hansruedi Mathys, Yue Qiu, Joe C. Udeochu, David Le, Lei Xie, Linas Mazutis, Xueting Wang, Michael DeTure, Georgia R. Frost, Gillian K. Carling, John Hardy, Li Fan, Wenjie Luo, Li Gan, Zuolin Cheng, Lay Kodama, Fei Wang, Giovanni Coppola, Maria Telpoukhovskaia, Man Ying Wong, Fuying Gao, Minghui Wang, Matthew Brendel, Guoqiang Yu, Tara E. Tracy, Xiang Niu, Bin Zhang, Yaqiao Li, Faten A. Sayed, Dennis W. Dickson, Yungui Zhou, Lu Zhou, Xueqiao Jiang, Shiaoching Gong, Qingyun Li
The hemizygous R47H variant ofTREM2, a microglia-specific gene in the brain, increases risk for late-onset Alzheimer’s disease (AD). In this study, we identified a subpopulation of microglia with disease-enhancing proinflammatory signatures associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0aaf393e58f3fa98f504068eff9eae7
https://doi.org/10.1101/2020.07.24.218719
https://doi.org/10.1101/2020.07.24.218719
Autor:
Yue Ming Li, Valerie A. Longo, Simon R. Cherry, Carl Lekaye, Thomas Li, Lauren A. Jonas, Martin S. Judenhofer, Jason A. Koutcher, Pat Zanzonico, Georgia R. Frost
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific reports, vol 10, iss 1
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific reports, vol 10, iss 1
The emergence of PET probes for amyloid plaques and neurofibrillary tangles, hallmarks of Alzheimer disease (AD), enables monitoring of pathology in AD mouse models. However, small-animal PET imaging is limited by coarse spatial resolution. We have i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578deed3d1724f42881c010cdc7de84d
http://europepmc.org/articles/PMC7316864
http://europepmc.org/articles/PMC7316864