The Entrapment of Somatostatin in a Lipid Formulation: Retarded Release and Free Radical Reactivity

Autor: Anna Vita Larocca, Gianluca Toniolo, Silvia Tortorella, Marios G. Krokidis, Georgia Menounou, Giuseppe Di Bella, Chryssostomos Chatgilialoglu, Carla Ferreri

Publikováno v: Molecules, Vol 24, Iss 17, p 3085 (2019)

The natural peptide somatostatin has hormonal and cytostatic effects exerted by the binding to specific receptors in various tissues. Therapeutic uses are strongly prevented by its very short biological half-life of 1–2 min due to enzymatic hydroly

Externí odkaz: https://doaj.org/article/1505fdb093584283bee4d7fe23b7b657

Copper(II) and silver(I)-1,10-phenanthroline-5,6-dione complexes interact with double-stranded DNA: further evidence of their apparent multi-modal activity towards Pseudomonas aeruginosa

Autor: Anna Clara Milesi Galdino, Lívia Viganor, Matheus Mendonça Pereira, Michael Devereux, Malachy McCann, Marta Helena Branquinha, Zara Molphy, Sinéad O’Carroll, Conor Bain, Georgia Menounou, Andrew Kellett, André Luis Souza dos Santos

Publikováno v: Articles
JBIC Journal of Biological Inorganic Chemistry

Tackling microbial resistance requires continuous efforts for the development of new molecules with novel mechanisms of action and potent antimicrobial activity. Our group has previously identified metal-based compounds, [Ag(1,10-phenanthroline-5,6-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9258f0b5d3eacd3d585d2c363cadaf86
https://doi.org/10.1007/s00775-021-01922-3

Polypyridyl-Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition

Autor: John Colleran, Nicoló Zuin Fantoni, Sinéad O'Carroll, Chryssostomos Chatgilialoglu, Suainibhe Kelly, Anna Banasiak, Martin Clynes, Georgia Menounou, Andrew Kellett, George Mitrikas, Sandra Roche, Vickie McKee, Marios G. Krokidis, Zara Molphy

Publikováno v: Fantoni, N Z, Molphy, Z, O'Carroll, S, Menounou, G, Mitrikas, G, Krokidis, M G, Chatgilialoglu, C, Colleran, J, Banasiak, A, Clynes, M, Roche, S, Kelly, S, McKee, V & Kellett, A 2021, ' Polypyridyl-Based Copper Phenanthrene Complexes : Combining Stability with Enhanced DNA Recognition ', Chemistry-A European Journal, vol. 27, no. 3, pp. 971-983 . https://doi.org/10.1002/chem.202001996

We report a series of copper(II) artificial metallo-nucleases (AMNs) and demonstrate their DNA damaging properties and in-vitro cytotoxicity against human-derived pancreatic cancer cells. The compounds combine a tris-chelating polypyridyl ligand, di-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a429f0b85d62025e480930b686f3e22
https://pubmed.ncbi.nlm.nih.gov/32519773

Polypyridyl‐Based Copper Phenanthrene Complexes: A New Type of Stabilized Artificial Chemical Nuclease

Autor: Gianluca Toniolo, Vickie McKee, Nicoló Zuin Fantoni, Zara Molphy, George Mitrikas, Andrew Kellett, Chryssostomos Chatgilialoglu, Georgia Menounou, Creina Slator

Publikováno v: Chemistry-A European Journal 25 (2019): 221–237. doi:10.1002/chem.201804084
info:cnr-pdr/source/autori:Zuin Fantoni N.; Molphy Z.; Slator C.; Menounou G.; Toniolo G.; Mitrikas G.; McKee V.; Chatgilialoglu C.; Kellett A./titolo:Polypyridyl-Based Copper Phenanthrene Complexes: A New Type of Stabilized Artificial Chemical Nuclease/doi:10.1002%2Fchem.201804084/rivista:Chemistry-A European Journal/anno:2019/pagina_da:221/pagina_a:237/intervallo_pagine:221–237/volume:25
Chemistry-A European Journal
Zuin Fantoni, N, Molphy, Z, Slator, C, Menounou, G, Toniolo, G, Mitrikas, G, McKee, V, Chatgilialoglu, C & Kellett, A 2019, ' Polypyridyl-Based Copper Phenanthrene Complexes : A New Type of Stabilized Artificial Chemical Nuclease ', Chemistry: A European Journal, vol. 25, no. 1, pp. 221-237 . https://doi.org/10.1002/chem.201804084

The building of robust and versatile inorganic scaffolds with artificial metallo-nuclease (AMN) activity is an important goal for bioinorganic, biotechnology, and metallodrug research fields. Here, a new type of AMN combining a tris-(2-pyridylmethyl)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e635f4fad7e296cb0918c0a8962bb5c
https://doi.org/10.1002/chem.201804084

Effects of somatostatin and vitamin C on the fatty acid profile of breast cancer cell membranes

Autor: Tomris Ozben, Ferhat Hanikoglu, Giuseppe Di Bella, Carla Ferreri, Ertan Kucuksayan, Aysegul Hanikoglu, Anna Sansone, Georgia Menounou, Chrys Chatgilialoglu

Publikováno v: Anti-cancer agents in medicinal chemistry (Online) (2019). doi:10.2174/1871520619666190930130732
info:cnr-pdr/source/autori:ysegul Hanikoglu, Ertan Kucuksayan, Ferhat Hanikoglu, Tomris Ozben*, Georgia Menounou, Anna Sansone, Chrys Chatgilialoglu, Giuseppe Di Bella, Carla Ferreri/titolo:Effects of Somatostatin and Vitamin C on the Fatty Acid Profile of Breast Cancer Cell Membranes./doi:10.2174%2F1871520619666190930130732/rivista:Anti-cancer agents in medicinal chemistry (Online)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume

Kucuksayan, Ertan/0000-0002-1611-0875 WOS: 000506818900011 PubMed: 31566138 Background: Vitamin C (Vit C) is an important physiological antioxidant with growing applications in cancer. Somatostatin (SST) is a natural peptide with growth inhibitory ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ad2357ad66f41682eab4b4f9d9f3e6
https://hdl.handle.net/20.500.12445/1733