Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Georgia L, Isom"'
Autor:
Ashira Lubkin, Lucie Bernard-Raichon, Ashley L. DuMont, Ana Mayela Valero Jimenez, Gregory G. Putzel, Juan Gago, Erin E. Zwack, Olufolakemi Olusanya, Kristina M. Boguslawski, Simone Dallari, Sophie Dyzenhaus, Christin Herrmann, Juliana K. Ilmain, Georgia L. Isom, Miranda Pawline, Andrew I. Perault, Sofya Perelman, William E. Sause, Ifrah Shahi, Amelia St. John, Rebecca Tierce, Xuhui Zheng, Chunyi Zhou, Maria G. Noval, Anna O'Keeffe, Magda Podkowik, Sandra Gonzales, Kenneth Inglima, Ludovic Desvignes, Sarah E. Hochman, Kenneth A. Stapleford, Lorna E. Thorpe, Alejandro Pironti, Bo Shopsin, Ken Cadwell, Meike Dittmann, Victor J. Torres
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT Severe COVID-19 has been associated with coinfections with bacterial and fungal pathogens. Notably, patients with COVID-19 who develop Staphylococcus aureus bacteremia exhibit higher rates of mortality than those infected with either pathoge
Externí odkaz:
https://doaj.org/article/623845162cdd4f2baf78452f589aa583
Autor:
Emily C A Goodall, Georgia L Isom, Jessica L Rooke, Karthik Pullela, Christopher Icke, Zihao Yang, Gabriela Boelter, Alun Jones, Isabel Warner, Rochelle Da Costa, Bing Zhang, James Rae, Wee Boon Tan, Matthias Winkle, Antoine Delhaye, Eva Heinz, Jean-Francois Collet, Adam F Cunningham, Mark A Blaskovich, Robert G Parton, Jeff A Cole, Manuel Banzhaf, Shu-Sin Chng, Waldemar Vollmer, Jack A Bryant, Ian R Henderson
Publikováno v:
PLoS Genetics, Vol 17, Iss 12, p e1009586 (2021)
The cell envelope is essential for viability in all domains of life. It retains enzymes and substrates within a confined space while providing a protective barrier to the external environment. Destabilising the envelope of bacterial pathogens is a co
Externí odkaz:
https://doaj.org/article/ec2a22d24ae74fa89c1da995d1848199
Autor:
Nicolas Coudray, Georgia L Isom, Mark R MacRae, Mariyah N Saiduddin, Gira Bhabha, Damian C Ekiert
Publikováno v:
eLife, Vol 9 (2020)
In double-membraned bacteria, phospholipid transport across the cell envelope is critical to maintain the outer membrane barrier, which plays a key role in virulence and antibiotic resistance. An MCE transport system called Mla has been implicated in
Externí odkaz:
https://doaj.org/article/4016616d4aad4d58a6b5047540cc998d
Autor:
Ljuvica R Kolich, Ya-Ting Chang, Nicolas Coudray, Sabrina I Giacometti, Mark R MacRae, Georgia L Isom, Evelyn M Teran, Gira Bhabha, Damian C Ekiert
Publikováno v:
eLife, Vol 9 (2020)
ABC transporters facilitate the movement of diverse molecules across cellular membranes, but how their activity is regulated post-translationally is not well understood. Here we report the crystal structure of MlaFB from E. coli, the cytoplasmic port
Externí odkaz:
https://doaj.org/article/3537baf37d634cd1915f09b00ac02461
Autor:
Georgia L. Isom, Nathaniel J. Davies, Zhi-Soon Chong, Jack A. Bryant, Mohammed Jamshad, Maria Sharif, Adam F. Cunningham, Timothy J. Knowles, Shu-Sin Chng, Jeffrey A. Cole, Ian R. Henderson
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Bacterial proteins with MCE domains were first described as being important for Mammalian Cell Entry. More recent evidence suggests they are components of lipid ABC transporters. In Escherichia coli, the single-domain protein MlaD is known t
Externí odkaz:
https://doaj.org/article/946c60bcdf82485e9f3e638e0b3e3962
Publikováno v:
J Mol Biol
LetB is a tunnel-forming protein found in the cell envelope of some double-membraned bacteria, and is thought to be important for the transport of lipids between the inner and outer membranes. In Escherichia coli the LetB tunnel is formed from a stac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df69a5abb8186c417c1bc74f2da4525f
https://doi.org/10.1101/2021.09.30.462657
https://doi.org/10.1101/2021.09.30.462657
Autor:
Peter J. Wotherspoon, Christopher J. Harding, Gareth W. Hughes, Yasin Yakub, Jack A. Bryant, Mohammed Jamshad, Pooja Sridhar, Damon Huber, Andrew L. Lovering, Aneika C. Leney, Luke A. Clifton, Vaclav Spana, Rebecca J. Parr, Amirul H. Mahadi, Stephen Hall, Georgia L. Isom, Claire S. Laxton, Douglas G. Ward, Ian R. Henderson, Timothy J. Knowles, Mark Jeeves, Caitlin Hatton, Thomas J. Piggot, Ian T. Cadby
Publikováno v:
Nature Microbiology. 4:1692-1705
The Mla pathway is believed to be involved in maintaining the asymmetrical Gram-negative outer membrane via retrograde phospholipid transport. The pathway is composed of three components: the outer membrane MlaA-OmpC/F complex, a soluble periplasmic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7ca874e392769f594e10b0ee8c93cb5
https://doi.org/10.1038/s41564-019-0481-y
https://doi.org/10.1038/s41564-019-0481-y
Autor:
Shu-Sin Chng, James Rae, Jean-François Collet, Karthik Pullela, Eva Heinz, Bing Zhang, Georgia L. Isom, Emily C. A. Goodall, Matthias Winkle, Mark A. T. Blaskovich, Jessica L. Rooke, Waldemar Vollmer, Ian R. Henderson, Wee Boon Tan, Christopher Icke, Antoine Delhaye, Adam F. Cunningham, Jeffrey A. Cole, Jack A. Bryant, Robert G. Parton
The cell envelope is essential for viability in all kingdoms of life. It retains enzymes and substrates within a confined space while providing a protective barrier to the external environment. Destabilising the envelope of bacterial pathogens is a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c1f8cd32d6adfb5dcd7d716fea11e89
https://doi.org/10.1101/2021.04.16.440158
https://doi.org/10.1101/2021.04.16.440158
Autor:
Mariyah N. Saiduddin, Gira Bhabha, Georgia L. Isom, Damian C. Ekiert, Mark R. MacRae, Nicolas Coudray
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
In double-membraned bacteria, phospholipids must be transported across the cell envelope to maintain the outer membrane barrier, which plays a key role in antibiotic resistance and pathogen virulence. The Mla system has been implicated in phospholipi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f7952e3aef03a3a7cad569f8a7491f
https://elifesciences.org/articles/62518
https://elifesciences.org/articles/62518