Molecular Biomarkers for Predicting Cancer Patient Radiosensitivity and Radiotoxicity in Clinical Practice

Autor: Angeliki Gkikoudi, Spyridon A. Kalospyros, Sotiria Triantopoulou, Stella Logotheti, Vasiliki Softa, Constantin Kappas, Kiki Theodorou, Evagelia C. Laiakis, Gina Manda, Georgia I. Terzoudi, Alexandros G. Georgakilas

Publikováno v: Applied Sciences, Vol 13, Iss 23, p 12564 (2023)

Radiotherapy (RT) is a major part of cancer treatment. The reported variability in patient response to this modality can interfere with the continuation of best-possible care, promote side effects, and lead to long-term morbidity. Tools to predict a

Externí odkaz: https://doaj.org/article/c4033d0681a14b8b9e298da249363b60

G2/M Checkpoint Abrogation With Selective Inhibitors Results in Increased Chromatid Breaks and Radiosensitization of 82-6 hTERT and RPE Human Cells

Autor: Aggeliki Nikolakopoulou, Aashish Soni, Martha Habibi, Pantelis Karaiskos, Gabriel Pantelias, Georgia I. Terzoudi, George Iliakis

Publikováno v: Frontiers in Public Health, Vol 9 (2021)

While technological advances in radiation oncology have led to a more precise delivery of radiation dose and a decreased risk of side effects, there is still a need to better understand the mechanisms underlying DNA damage response (DDR) at the DNA a

Externí odkaz: https://doaj.org/article/52a5985618e9403fb7780f9678497bd3

RENEB Inter-Laboratory comparison 2017: limits and pitfalls of ILCs

Autor: Inmaculada Domínguez, Joan Francesc Barquinero, Alegría Montoro, Jayne Moquet, Andrzej Wojcik, Anne Vral, Georgia I. Terzoudi, I. Guclu, Katalin Lumniczky, Seongjae Jang, Mercedes Moreno, William F. Blakely, Ruth C. Wilkins, Ursula Oestreicher, Antonella Testa, Farrah Norton, M. Benadjaoud, Eric Gregoire, M. Prakash Hande, Mirta Milić, Octávia Monteiro Gil, Jelena Pajic, Pham Ngoc Duy, Roberta Meschini, Christina Beinke, Gaëtan Gruel, P. Beukes, Perumal Venkatachalam, D. Zafiropoulos, Laure Sabatier, Juan S. Martinez, Sylwester Sommer, Savina Hadjidekova, Kamile Guogyte, Ulrike Kulka, M. Valente, Adayabalam S. Balajee, Valeria Hadjidekova

Publikováno v: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
International Journal of Radiation Biology
International Journal of Radiation Biology, 2021, 97 (7), pp.888-905. ⟨10.1080/09553002.2021.1928782⟩

Purpose In case of a mass-casualty radiological event, there would be a need for networking to overcome surge limitations and to quickly obtain homogeneous results (reported aberration frequencies or estimated doses) among biodosimetry laboratories.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ace4a52d198627fcda7e301b69e6ab
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=14986

RENEB/EURADOS Field Exercise 2019: Robust Dose Estimation under outdoor Conditions based on the Dicentric Chromosome Assay

Autor: Octávia Monteiro Gil, Ursula Oestreicher, Rositsa Histova, Olga Sevriukova, Laure Bobyk, Yoann Ristic, Antonella Testa, Juan S. Martinez, Clemens Woda, Alfredo Hernandez, Ulrike Kulka, Lovisa Waldner, Eric Gregoire, Georgia I. Terzoudi, Elizabeth A. Ainsbury, Sotiria Triantopoulou, Alegría Montoro, Mirta Milić, Joan Francesc Barquinero, Andrzej Wojcik, Anne Vral, Katalin Lumniczky, David Endesfelder, Sylwester Sommer, Laure Sabatier, François Trompier, Clarice Patrono, M. Valente, Rita Hargitai, Stephen Barnard, Christina Beinke, Mercedes Moreno Domene, Jayne Moquet, María Jesús Prieto

Publikováno v: International Journal of Radiation Biology
International Journal of Radiation Biology, Informa Healthcare, 2021, 97 (9), pp.1181-1198. ⟨10.1080/09553002.2021.1941380⟩
International Journal of Radiation Biology, 2021, 97 (9), pp.1181-1198. ⟨10.1080/09553002.2021.1941380⟩
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

Purpose: Depending on the exposure scenario, different biological and/or physical assays will be required to recover the exposure situation and to obtain reliable dose estimates to aid medical decision making. Inter-laboratory comparisons (ILCs) are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53015ba80e8de873dd26169d97b28061
https://doi.org/10.1080/09553002.2021.1941380

Interphase Cytogenetic Analysis of Micronucleated and Multinucleated Cells Supports the Premature Chromosome Condensation Hypothesis as the Mechanistic Origin of Chromothripsis

Autor: Alexandros G. Georgakilas, Ioanna Karachristou, Antonio Pantelias, Georgia I. Terzoudi

Publikováno v: Cancers
Volume 11
Issue 8
Cancers, Vol 11, Iss 8, p 1123 (2019)

The discovery of chromothripsis in cancer genomes challenges the long-standing concept of carcinogenesis as the result of progressive genetic events. Despite recent advances in describing chromothripsis, its mechanistic origin remains elusive. The pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d324f7e86b6ff72fc9c6203ccf75f8b