Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Georgia Dolios"'
Autor:
Lauren Petrick, Haibin Guan, Grier P. Page, Georgia Dolios, Megan M. Niedzwiecki, Robert O. Wright, Rosalind J. Wright
Publikováno v:
Environment International, Vol 187, Iss , Pp 108663- (2024)
Use of capillary blood devices for exposome research can deepen our understanding of the intricate relationship between environment and health, and open up new avenues for preventive and personalized medicine, particularly for vulnerable populations.
Externí odkaz:
https://doaj.org/article/bbea3ccd417743218a62ee0aa1975acc
Publikováno v:
Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-10 (2022)
Abstract Unknown features in untargeted metabolomics and non-targeted analysis (NTA) are identified using fragment ions from MS/MS spectra to predict the structures of the unknown compounds. The precursor ion selected for fragmentation is commonly pe
Externí odkaz:
https://doaj.org/article/8e3f8d87b16b4bb1bd5d18763634b784
Autor:
Megan M. Niedzwiecki, Shoshannah Eggers, Anu Joshi, Georgia Dolios, Alejandra Cantoral, Héctor Lamadrid-Figueroa, Chitra Amarasiriwardena, Martha M. Téllez-Rojo, Robert O. Wright, Lauren Petrick
Publikováno v:
Environmental Health, Vol 20, Iss 1, Pp 1-11 (2021)
Abstract Background Lead (Pb) exposure is a global health hazard causing a wide range of adverse health outcomes. Yet, the mechanisms of Pb toxicology remain incompletely understood, especially during pregnancy. To uncover biological pathways impacte
Externí odkaz:
https://doaj.org/article/073b4ac0bf9848109bbb955fca8f5d8f
Autor:
Fannie W. Chen, Joanna P. Davies, Raul Calvo, Jagruti Chaudhari, Georgia Dolios, Mercedes K. Taylor, Samarjit Patnaik, Jean Dehdashti, Rebecca Mull, Patricia Dranchack, Amy Wang, Xin Xu, Emma Hughes, Noel Southall, Marc Ferrer, Rong Wang, Juan J. Marugan, Yiannis A. Ioannou
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104941- (2022)
Summary: Numerous studies have established the involvement of lysosomal and mitochondrial dysfunction in the pathogenesis of neurodegenerative disorders such as Alzheimer’s and Parkinson diseases. Building on our previous studies of the neurodegene
Externí odkaz:
https://doaj.org/article/e19a65a93a4f4b3fb15bf654a093fa23
Autor:
Miao Yu, Peijun Tu, Georgia Dolios, Priyanthi S. Dassanayake, Heather Volk, Craig Newschaffer, M. Daniele Fallin, Lisa Croen, Kristen Lyall, Rebecca Schmidt, Irva Hertz-Piccioto, Christine Austin, Manish Arora, Lauren M. Petrick
Publikováno v:
Environment International, Vol 157, Iss , Pp 106849- (2021)
Background: Teeth have unique histology that make this biomatrix a time-capsule for retrospective exposure analysis of fetal and early life. However, most analytic methods require pulverizing the whole tooth, which eliminates exposure timing informat
Externí odkaz:
https://doaj.org/article/c5ddb1d5f17f4b90bf6d1233d97a3ac3
Autor:
Vicki Betts, Malcolm A. Leissring, Georgia Dolios, Rong Wang, Dennis J. Selkoe, Dominic M. Walsh
Publikováno v:
Neurobiology of Disease, Vol 31, Iss 3, Pp 442-450 (2008)
Five point mutations within the amyloid β-protein (Aβ) sequence of the APP gene are associated with hereditary diseases which are similar or identical to Alzheimer's disease and encode: the A21G (Flemish), E22G (Arctic), E22K (Italian), E22Q (Dutch
Externí odkaz:
https://doaj.org/article/47d09018a227404694bb030ea20b80e0
Publikováno v:
Neurobiology of Disease, Vol 17, Iss 2, Pp 205-218 (2004)
Understanding the molecular mechanism of β-amyloid (Aβ) generation is crucial for Alzheimer's disease pathogenesis as well as for normal APP function. The transmembrane domain (TM) of APP appears to undergo presenilin-dependent γ-secretase cleavag
Externí odkaz:
https://doaj.org/article/b0481bb5e6a14fe78ed16b967189828b
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90770 (2014)
Recent studies indicate that soluble β-amyloid (sAβ) oligomers, rather than their fibrillar aggregates, contribute to the pathogenesis of Alzheimer's disease (AD), though the mechanisms of their neurotoxicity are still elusive. Here, we demonstrate
Externí odkaz:
https://doaj.org/article/69113d7d9ee644c39a95bae92cde00bf
Autor:
Celia Torres-Arancivia, Carolyn M Ross, Jose Chavez, Zahra Assur, Georgia Dolios, Filippo Mancia, Iban Ubarretxena-Belandia
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e744 (2010)
BACKGROUND: The GXGD-type diaspartyl intramembrane protease, presenilin, constitutes the catalytic core of the γ-secretase multi-protein complex responsible for activating critical signaling cascades during development and for the production of β-a
Externí odkaz:
https://doaj.org/article/a8987ef021a7453ca7faa5ca19b4c70b
Autor:
Maaike van Gerwen, Elena Colicino, Haibin Guan, Georgia Dolios, Girish N. Nadkarni, Roel C.H. Vermeulen, Mary Wolff, Manish Arora, Eric Michael Genden, Lauren M. Petrick
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94f37487d3c0dd19c1039159901f2f9b
https://doi.org/10.2139/ssrn.4397033
https://doi.org/10.2139/ssrn.4397033