Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors

Autor: Christina Lamers, Xiaoguang Xue, Martin Smieško, Henri van Son, Bea Wagner, Nadja Berger, Georgia Sfyroera, Piet Gros, John D. Lambris, Daniel Ricklin

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Therapeutic modulation of the complement system has gained interest over the past two decades. Here, the authors provide molecular-level insight into the mode-of-action, target selectivity and species specificity of the compstatin family of complemen

Externí odkaz: https://doaj.org/article/0c7331cff4f34721b958795607a6055b

Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors

Autor: Christina, Lamers, Xiaoguang, Xue, Martin, Smieško, Henri, van Son, Bea, Wagner, Nadja, Berger, Georgia, Sfyroera, Piet, Gros, John D, Lambris, Daniel, Ricklin

Publikováno v: Nature communications. 13(1)

With the addition of the compstatin-based complement C3 inhibitor pegcetacoplan, another class of complement targeted therapeutics have recently been approved. Moreover, compstatin derivatives with enhanced pharmacodynamic and pharmacokinetic profile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d489ea0ab9615b71c8b2af4897a01154
https://pubmed.ncbi.nlm.nih.gov/36127336

Commensal microbiota modulate gene expression in the skin

Autor: Amanda S. Tyldsley, Ciara Gimblet, Julia Bugayev, Elizabeth A. Grice, David Artis, Brian S. Kim, Joseph Horwinski, Qi Zheng, Casey Bartow-McKenney, Georgia Sfyroera, Brendan P. Hodkinson, Jacquelyn S. Meisel, Jonathan R. Brestoff

Publikováno v: Microbiome, Vol 6, Iss 1, Pp 1-15 (2018)
Microbiome

Background The skin harbors complex communities of resident microorganisms, yet little is known of their physiological roles and the molecular mechanisms that mediate cutaneous host-microbe interactions. Here, we profiled skin transcriptomes of mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec15986a014cf0419505deaba116334c
http://link.springer.com/article/10.1186/s40168-018-0404-9

The Extracellular Adherence Protein from Staphylococcus aureus Inhibits the Classical and Lectin Pathways of Complement by Blocking Formation of the C3 Proconvertase

Autor: Georgia Sfyroera, Brandon L. Garcia, Kasra X. Ramyar, Michal Zolkiewski, Maria Syriga, Andrew Keightley, Alexander B. Weber, Brian V. Geisbrecht, Daphne A.C. Stapels, Maartje Ruyken, Jordan L. Woehl, Daniel Ricklin, Suzan H.M. Rooijakkers, John D. Lambris

Publikováno v: The Journal of Immunology. 193:6161-6171

The pathogenic bacterium Staphylococcus aureus actively evades many aspects of human innate immunity by expressing a series of small inhibitory proteins. A number of these proteins inhibit the complement system, which labels bacteria for phagocytosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ba453b9cd0465ccf25d537ddf0ea09
https://doi.org/10.4049/jimmunol.1401600

Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode

Autor: Daniel Ricklin, Georgia Sfyroera, John P. Atkinson, Richard E. Hauhart, M. Kathryn Liszewski, Elena B. Volokhina, Joke C.M. Granneman, Federico Forneris, Zhuoer Lin, John D. Lambris, Piet Gros, Apostolia Tzekou, Xiaoguang Xue, Jin Wu, Paula Bertram

Publikováno v: 'EMBO Journal ', vol: 35, pages: 1133-1149 (2016)
EMBO Journal, 35, 1133-1149
The EMBO Journal
EMBO Journal, 35, 10, pp. 1133-1149
Europe PubMed Central

Regulators of complement activation (RCA) inhibit complement‐induced immune responses on healthy host tissues. We present crystal structures of human RCA (MCP, DAF, and CR1) and a smallpox virus homolog (SPICE) bound to complement component C3b. Ou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e52585566336e1ffac1e18ecf5a8b191
https://doi.org/10.15252/embj.201593673