Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Georgia, Dermentzaki"'
Autor:
Georgia Dermentzaki, Mattia Furlan, Iris Tanaka, Tommaso Leonardi, Paola Rinchetti, Patricia M.S. Passos, Alliny Bastos, Yuna M. Ayala, Jacob H. Hanna, Serge Przedborski, Dario Bonanomi, Mattia Pelizzola, Francesco Lotti
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113999- (2024)
Summary: Motor neuron (MN) demise is a hallmark of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Post-transcriptional gene regulation can control RNA’s fate, and defects in RNA processing are critical determinan
Externí odkaz:
https://doaj.org/article/464ceed631b845cfb653dd5c230fb38a
Autor:
Giulietta M. Riboldi, Irene Faravelli, Takaaki Kuwajima, Nicolas Delestrée, Georgia Dermentzaki, Mariangels De Planell-Saguer, Paola Rinchetti, Le Thi Hao, Christine C. Beattie, Stefania Corti, Serge Przedborski, George Z. Mentis, Francesco Lotti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Sumoylation is important for the assembly and function of the SMN complex, which plays a central role in RNA processing. Here the authors show that loss of this posttranslational modification impairs the ability of SMN to correct selective deficits i
Externí odkaz:
https://doaj.org/article/9ae40bf770e34a49910b6f8f9467d2e2
Autor:
Georgia Dermentzaki, Evangelia Dimitriou, Maria Xilouri, Helen Michelakakis, Leonidas Stefanis
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252975 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0060674.].
Externí odkaz:
https://doaj.org/article/923977d1502a4e9d9a6fa6329d0acb67
Autor:
Georgia Dermentzaki, Francesco Lotti
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
RNA modifications termed epitranscriptomics represent an additional layer of gene regulation similar to epigenetic mechanisms operating on DNA. The dynamic nature and the increasing number of RNA modifications offer new opportunities for a rapid fine
Externí odkaz:
https://doaj.org/article/2362480f9d0c4f9bacaabcab493de3b3
Autor:
Eduardo J, Pérez-Torres, Irina, Utkina-Sosunova, Vartika, Mishra, Peter, Barbuti, Mariangels, De Planell-Saguer, Georgia, Dermentzaki, Heather, Geiger, Anna O, Basile, Nicolas, Robine, Delphine, Fagegaltier, Kristin A, Politi, Paola, Rinchetti, Vernice, Jackson-Lewis, Matthew, Harms, Hemali, Phatnani, Francesco, Lotti, Serge, Przedborski
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(26)
Retromer is a heteropentameric complex that plays a specialized role in endosomal protein sorting and trafficking. Here, we report a reduction in the retromer proteins—vacuolar protein sorting 35 (VPS35), VPS26A, and VPS29—in patients with amyotr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cee62dbb0551e475875303d7da8644
https://pubmed.ncbi.nlm.nih.gov/35749364
https://pubmed.ncbi.nlm.nih.gov/35749364
Autor:
Serge Przedborski, Takaaki Kuwajima, Mariàngels de Planell-Saguer, Georgia Dermentzaki, Le Thi Hao, Giulietta Riboldi, Francesco Lotti, George Z. Mentis, Christine C. Beattie, Nicolas Delestrée, Stefania Corti, Irene Faravelli, Paola Rinchetti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
SMN is a ubiquitously expressed protein and is essential for life. SMN deficiency causes the neurodegenerative disease spinal muscular atrophy (SMA), the leading genetic cause of infant mortality. SMN interacts with itself and other proteins to form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8064d5c988f9ead8c81b5560c6706145
https://doaj.org/article/9ae40bf770e34a49910b6f8f9467d2e2
https://doaj.org/article/9ae40bf770e34a49910b6f8f9467d2e2
Autor:
Georgia Dermentzaki, Evangelia Dimitriou, Maria Xilouri, Helen Michelakakis, Leonidas Stefanis
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60674 (2013)
To date, a plethora of studies have provided evidence favoring an association between Gaucher disease (GD) and Parkinson's disease (PD). GD, the most common lysosomal storage disorder, results from the diminished activity of the lysosomal enzyme β-g
Externí odkaz:
https://doaj.org/article/faa94a4d56a34fc990d3a7fe59210ed6
Autor:
Christos Koros, Leonidas Stefanis, Roubina Antonelou, Dimitra Papadimitriou, Nikolaos Papagiannakis, Maria Stamelou, Marina Moraitou, Athina-Maria Simitsi, Georgia Dermentzaki, Matina Maniati, Helen Michelakakis
Publikováno v:
Neuroscience letters. 672
Background Variations of α-synuclein levels or species have been reported in Parkinson’s Disease (PD). There has been little systematic examination of erythrocytes, a rich source of α-synuclein. Methods Erythrocyte membranes were obtained from PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39cd7e2b5969624090d9934ae189eaf
https://pubmed.ncbi.nlm.nih.gov/29129675
https://pubmed.ncbi.nlm.nih.gov/29129675
Autor:
Lei Lu, Kristin A. Politi, Neil A. Shneider, Francesco Lotti, Alexander A. Sosunov, Vartika Mishra, Georgia Dermentzaki, Eduardo J. Perez-Torres, Guy M. McKhann, Serge Przedborski
Publikováno v:
eNeuro
Increasing evidence suggests that necroptosis, a form of programmed cell death (PCD), contributes to neurodegeneration in several disorders, including ALS. Supporting this view, investigations in bothin vitroandin vivomodels of ALS have implicated ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9dbbb06e5c0da91d36b83cb25ac910
https://doi.org/10.1523/eneuro.0308-18.2018
https://doi.org/10.1523/eneuro.0308-18.2018
Autor:
Helen Michelakakis, Leonidas Stefanis, Nick Dekker, Georgia Dermentzaki, Ioannis Monopolis, Marina Moraitou, E. Dimitriou, Hans Aerts
Publikováno v:
Neuroscience letters, 613, 1-5. Elsevier Ireland Ltd
Several observations suggest that disturbed homeostasis of α-Synuclein (α-Syn) may provide a link between Gaucher disease (GD) and Parkinson's disease (PD). We recently reported increased dimerization of α-Syn in the red blood cell (RBC) membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c076209d0f6f2ed72d3de06b519525e
https://hdl.handle.net/1887/3199778
https://hdl.handle.net/1887/3199778
