Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Georgi K Marinov"'
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274509 (2022)
BackgroundThe COVID-19 pandemic has had a devastating impact on the world over the past two years (2020-2021). One of the key questions about its future trajectory is the protection from subsequent infections and disease conferred by a previous infec
Externí odkaz:
https://doaj.org/article/151f26306359423a878daf82d5defe93
Autor:
Rajiv Movva, Peyton Greenside, Georgi K Marinov, Surag Nair, Avanti Shrikumar, Anshul Kundaje
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218073 (2019)
The relationship between noncoding DNA sequence and gene expression is not well-understood. Massively parallel reporter assays (MPRAs), which quantify the regulatory activity of large libraries of DNA sequences in parallel, are a powerful approach to
Externí odkaz:
https://doaj.org/article/e40371fbb0544d5ea9bf64ac57fab03d
Autor:
Michael Lynch, Georgi K Marinov
Publikováno v:
eLife, Vol 6 (2017)
The evolution of the eukaryotic cell marked a profound moment in Earth’s history, with most of the visible biota coming to rely on intracellular membrane-bound organelles. It has been suggested that this evolutionary transition was critically depen
Externí odkaz:
https://doaj.org/article/62c44a4f7ce34ebf80e896ec359c977f
Autor:
Georgi K. Marinov, Xinyi Chen, Matthew P. Swaffer, Tingting Xiang, Arthur R. Grossman, William J. Greenleaf
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-24 (2024)
Abstract Background In dinoflagellates, a unique and extremely divergent genomic and nuclear organization has evolved. The highly unusual features of dinoflagellate nuclei and genomes include permanently condensed liquid crystalline chromosomes, prim
Externí odkaz:
https://doaj.org/article/3a281a83cbc549b9ad2346e7db762d70
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84713 (2014)
Mitochondria contain their own circular genome, with mitochondria-specific transcription and replication systems and corresponding regulatory proteins. All of these proteins are encoded in the nuclear genome and are post-translationally imported into
Externí odkaz:
https://doaj.org/article/2d458abd4161448a8f50021226095dd1
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 102941- (2024)
Summary: Dinoflagellate genomes often are very large and difficult to assemble, which has until recently precluded their analysis with modern functional genomic tools. Here, we present a protocol for mapping three-dimensional (3D) genome organization
Externí odkaz:
https://doaj.org/article/3f0a0a658f4e49b5a2ffb0de2e560769
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e74513 (2013)
Mitochondria contain a 16.6 kb circular genome encoding 13 proteins as well as mitochondrial tRNAs and rRNAs. Copies of the genome are organized into nucleoids containing both DNA and proteins, including the machinery required for mtDNA replication a
Externí odkaz:
https://doaj.org/article/38cdba56ab2544b7a0dd7fe6d0aec73e
Autor:
Georgi K. Marinov, S. Tansu Bagdatli, Tong Wu, Chuan He, Anshul Kundaje, William J. Greenleaf
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-22 (2023)
Abstract Background Archaea, together with Bacteria, represent the two main divisions of life on Earth, with many of the defining characteristics of the more complex eukaryotes tracing their origin to evolutionary innovations first made in their arch
Externí odkaz:
https://doaj.org/article/f78a9dc33c4f4e17b113e1b35f86f569
Autor:
Georgi K. Marinov, Samuel H. Kim, S. Tansu Bagdatli, Soon Il Higashino, Alexandro E. Trevino, Josh Tycko, Tong Wu, Lacramioara Bintu, Michael C. Bassik, Chuan He, Anshul Kundaje, William J. Greenleaf
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Detecting and mitigating off-target activity is critical to the practical application of CRISPR-mediated genome and epigenome editing. While numerous methods have been developed to map Cas9 binding specificity genome-wide, they are generally
Externí odkaz:
https://doaj.org/article/2a29028e5573430ebf0d2f915bbb3450
Autor:
Karen S. Aboody, Kaniel Cassady, Georgi K. Marinov, Gregory A. Cherryholmes, Rosyli F. Reveron-Thornton, Monika D. Polewski
Supplementary Figure 1. Pharmacologic inhibition with SSZ inhibits proliferation of U251 glioma cells in a dose-dependent manner while increasing apoptosis. Supplementary Figure 2. Establishment of stable lentivirus-transduced shSLC7A11 and SLC7A11 U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca59f15d77764ab7eefb473f266dfab
https://doi.org/10.1158/1541-7786.22511455
https://doi.org/10.1158/1541-7786.22511455
