Zobrazeno 1 - 10
of 884
pro vyhledávání: '"Georgi K"'
Autor:
Georgi K. Marinov, Xinyi Chen, Matthew P. Swaffer, Tingting Xiang, Arthur R. Grossman, William J. Greenleaf
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-24 (2024)
Abstract Background In dinoflagellates, a unique and extremely divergent genomic and nuclear organization has evolved. The highly unusual features of dinoflagellate nuclei and genomes include permanently condensed liquid crystalline chromosomes, prim
Externí odkaz:
https://doaj.org/article/3a281a83cbc549b9ad2346e7db762d70
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 102941- (2024)
Summary: Dinoflagellate genomes often are very large and difficult to assemble, which has until recently precluded their analysis with modern functional genomic tools. Here, we present a protocol for mapping three-dimensional (3D) genome organization
Externí odkaz:
https://doaj.org/article/3f0a0a658f4e49b5a2ffb0de2e560769
Autor:
Georgi K. Marinov, S. Tansu Bagdatli, Tong Wu, Chuan He, Anshul Kundaje, William J. Greenleaf
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-22 (2023)
Abstract Background Archaea, together with Bacteria, represent the two main divisions of life on Earth, with many of the defining characteristics of the more complex eukaryotes tracing their origin to evolutionary innovations first made in their arch
Externí odkaz:
https://doaj.org/article/f78a9dc33c4f4e17b113e1b35f86f569
AN UNCOMMON CASE OF FILUM TERMINALE HEMANGIOBLASTOMA NON-ASSOCIATED WITH VON HIPPEL – LINDAU DISEASE
Publikováno v:
Journal of IMAB, Vol 29, Iss 4, Pp 5236-5239 (2023)
A 55-year-old man presented with low backache, paraesthesia, and spasticity of both lower limbs. He had urinary retention and constipation. Investigations revealed a vascular intradural cauda equina tumor. MRI scan demonstrated an enhancing mass at
Externí odkaz:
https://doaj.org/article/285d8c3073854757b4b415be94e2114d
Autor:
Georgi K. Marinov, Samuel H. Kim, S. Tansu Bagdatli, Soon Il Higashino, Alexandro E. Trevino, Josh Tycko, Tong Wu, Lacramioara Bintu, Michael C. Bassik, Chuan He, Anshul Kundaje, William J. Greenleaf
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Detecting and mitigating off-target activity is critical to the practical application of CRISPR-mediated genome and epigenome editing. While numerous methods have been developed to map Cas9 binding specificity genome-wide, they are generally
Externí odkaz:
https://doaj.org/article/2a29028e5573430ebf0d2f915bbb3450
Autor:
Georgi K Kanev, Yaran Zhang, Albert J Kooistra, Andreas Bender, Rob Leurs, David Bailey, Thomas Würdinger, Chris de Graaf, Iwan J P de Esch, Bart A Westerman
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 9, p e1011301 (2023)
Many therapies in clinical trials are based on single drug-single target relationships. To further extend this concept to multi-target approaches using multi-targeted drugs, we developed a machine learning pipeline to unravel the target landscape of
Externí odkaz:
https://doaj.org/article/3875d0fdcc1341ac8c4a8184e67a02c7
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The COVID-19 pandemic followed a unique trajectory in Eastern Europe compared to other heavily affected regions, with most countries there only experiencing a major surge of cases and deaths towards the end of 2020 after a relatively unevent
Externí odkaz:
https://doaj.org/article/4f181e1f360a430f8bf0ced1b5a6a51a
Autor:
Georgi K. Marinov, Xinyi Chen, Tong Wu, Chuan He, Arthur R. Grossman, Anshul Kundaje, William James Greenleaf
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-18 (2022)
Abstract Background Nucleomorphs are remnants of secondary endosymbiotic events between two eukaryote cells wherein the endosymbiont has retained its eukaryotic nucleus. Nucleomorphs have evolved at least twice independently, in chlorarachniophytes a
Externí odkaz:
https://doaj.org/article/5194fc1b7d8f4d88b72dd079ab49b2bd
Autor:
Ke-En Tan, Wei Lun Ng, Georgi K. Marinov, Ken Hung-On Yu, Lu Ping Tan, Ee Shan Liau, Sook Yan Goh, Kok Siong Yeo, Kevin Y. Yip, Kwok-Wai Lo, Alan Soo-Beng Khoo, Lee-Fah Yap, Chee-Kwee Ea, Yat-Yuen Lim
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Epstein-Barr virus (EBV) has been recently found to generate novel circular RNAs (circRNAs) through backsplicing. However, comprehensive catalogs of EBV circRNAs in other cell lines and their functional characterization are still lacking. In
Externí odkaz:
https://doaj.org/article/6f280b89ec074aafa9b102c63d7b3441
Autor:
Georgi K. Georgiev, Ivan V. Todorov, Todor P. Shamov, Ivan V. Krushovenski, Albena D. Fakirova, Boryana N. Ilcheva, Iliyan T. Georgiev, Nikolai D. Georgiev, Vladimir S. Prandjev, Tihomir N. Eftimov
Publikováno v:
Folia Medica, Vol 63, Iss 3, Pp 448-456 (2021)
First described by Miller in 1932, melanocytic schwannoma (MS) (melanotic schwannoma, pigmented schwannoma) is a rare variation of peripheral nerve sheet tumours with ectodermal origin occurring predominantly in somatic, but also in the autonomic per
Externí odkaz:
https://doaj.org/article/86683fa01f1947b6b1337b4b8955e549