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of 2 520
pro vyhledávání: '"Georgi K"'
Autor:
Georgi K. Marinov, Xinyi Chen, Matthew P. Swaffer, Tingting Xiang, Arthur R. Grossman, William J. Greenleaf
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-24 (2024)
Abstract Background In dinoflagellates, a unique and extremely divergent genomic and nuclear organization has evolved. The highly unusual features of dinoflagellate nuclei and genomes include permanently condensed liquid crystalline chromosomes, prim
Externí odkaz:
https://doaj.org/article/3a281a83cbc549b9ad2346e7db762d70
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 102941- (2024)
Summary: Dinoflagellate genomes often are very large and difficult to assemble, which has until recently precluded their analysis with modern functional genomic tools. Here, we present a protocol for mapping three-dimensional (3D) genome organization
Externí odkaz:
https://doaj.org/article/3f0a0a658f4e49b5a2ffb0de2e560769
Autor:
Georgi K. Marinov, S. Tansu Bagdatli, Tong Wu, Chuan He, Anshul Kundaje, William J. Greenleaf
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-22 (2023)
Abstract Background Archaea, together with Bacteria, represent the two main divisions of life on Earth, with many of the defining characteristics of the more complex eukaryotes tracing their origin to evolutionary innovations first made in their arch
Externí odkaz:
https://doaj.org/article/f78a9dc33c4f4e17b113e1b35f86f569
AN UNCOMMON CASE OF FILUM TERMINALE HEMANGIOBLASTOMA NON-ASSOCIATED WITH VON HIPPEL – LINDAU DISEASE
Publikováno v:
Journal of IMAB, Vol 29, Iss 4, Pp 5236-5239 (2023)
A 55-year-old man presented with low backache, paraesthesia, and spasticity of both lower limbs. He had urinary retention and constipation. Investigations revealed a vascular intradural cauda equina tumor. MRI scan demonstrated an enhancing mass at
Externí odkaz:
https://doaj.org/article/285d8c3073854757b4b415be94e2114d
Autor:
Kanev, Georgi K.1,2 (AUTHOR), Zhang, Yaran2 (AUTHOR), Kooistra, Albert J.1,3 (AUTHOR), Bender, Andreas4 (AUTHOR), Leurs, Rob1 (AUTHOR), Bailey, David5,6 (AUTHOR), Würdinger, Thomas2,5 (AUTHOR), de Graaf, Chris1 (AUTHOR), de Esch, Iwan J. P.1 (AUTHOR), Westerman, Bart A.2,5 (AUTHOR) a.westerman@amsterdamumc.nl
Publikováno v:
PLoS Computational Biology. 9/5/2023, Vol. 19 Issue 9, p1-19. 19p. 4 Diagrams.
Akademický článek
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Autor:
Georgi K. Marinov, Samuel H. Kim, S. Tansu Bagdatli, Soon Il Higashino, Alexandro E. Trevino, Josh Tycko, Tong Wu, Lacramioara Bintu, Michael C. Bassik, Chuan He, Anshul Kundaje, William J. Greenleaf
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Detecting and mitigating off-target activity is critical to the practical application of CRISPR-mediated genome and epigenome editing. While numerous methods have been developed to map Cas9 binding specificity genome-wide, they are generally
Externí odkaz:
https://doaj.org/article/2a29028e5573430ebf0d2f915bbb3450
Autor:
Tang, Jun, Weiser, Natasha E., Wang, Guiping, Chowdhry, Sudhir, Curtis, Ellis J., Zhao, Yanding, Wong, Ivy Tsz-Lo, Marinov, Georgi K., Li, Rui, Hanoian, Philip, Tse, Edison, Mojica, Salvador Garcia, Hansen, Ryan, Plum, Joshua, Steffy, Auzon, Milutinovic, Snezana, Meyer, S. Todd, Luebeck, Jens, Wang, Yanbo, Zhang, Shu
Publikováno v:
Nature; Nov2024, Vol. 635 Issue 8037, p210-218, 9p
Autor:
Swaffer, Matthew P., Marinov, Georgi K., Zheng, Huan, Fuentes Valenzuela, Lucas, Tsui, Crystal Yee, Jones, Andrew W., Greenwood, Jessica, Kundaje, Anshul, Greenleaf, William J., Reyes-Lamothe, Rodrigo, Skotheim, Jan M.
Publikováno v:
In Cell 22 November 2023 186(24):5254-5268
Autor:
Georgi K Kanev, Yaran Zhang, Albert J Kooistra, Andreas Bender, Rob Leurs, David Bailey, Thomas Würdinger, Chris de Graaf, Iwan J P de Esch, Bart A Westerman
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 9, p e1011301 (2023)
Many therapies in clinical trials are based on single drug-single target relationships. To further extend this concept to multi-target approaches using multi-targeted drugs, we developed a machine learning pipeline to unravel the target landscape of
Externí odkaz:
https://doaj.org/article/3875d0fdcc1341ac8c4a8184e67a02c7