Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Georgi Danovski"'
Autor:
Georgi Danovski, Greta Panova, Bradley Keister, Georgi Georgiev, Aleksandar Atemin, Sonya Uzunova, Rumen Stamatov, Petar-Bogomil Kanev, Radoslav Aleksandrov, Krastan B. Blagoev, Stoyno S. Stoynov
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110826- (2024)
Summary: During DNA repair, ATM-induced H2AX histone phosphorylation and MDC1 recruitment spread megabases beyond the damage site. While loop extrusion has been suggested to drive this spread, the underlying mechanism remains unclear. Herein, we prov
Externí odkaz:
https://doaj.org/article/14a8058a4f0c4a75968a8af700c246cf
Autor:
Petar-Bogomil Kanev, Sylvia Varhoshkova, Irina Georgieva, Maria Lukarska, Dilyana Kirova, Georgi Danovski, Stoyno Stoynov, Radoslav Aleksandrov
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114234- (2024)
Summary: Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) not only suppress PARP1 catalytic activity but also prolong its association to damaged chromatin. Here, through live-cell imaging, we quantify the alterations in PARP1 dynamics and activ
Externí odkaz:
https://doaj.org/article/9e46a1e28703485d886e5375514f41e8
Autor:
Georgi Danovski, Teodora Dyankova-Danovska, Rumen Stamatov, Radoslav Aleksandrov, Petar-Bogomil Kanev, Stoyno Stoynov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16784 (2023)
Elucidating the dynamics of DNA repair proteins is essential to understanding the mechanisms that preserve genomic stability and prevent carcinogenesis. However, the measurement and modeling of protein dynamics at DNA lesions via currently available
Externí odkaz:
https://doaj.org/article/0c56d27aea7747c0ab8b361a1566f0fc
Autor:
Aneliya Ivanova, Aleksandar Atemin, Sonya Uzunova, Georgi Danovski, Radoslav Aleksandrov, Stoyno Stoynov, Marina Nedelcheva-Veleva
Publikováno v:
Molecules, Vol 27, Iss 1, p 97 (2021)
Cells have evolved elaborate mechanisms to regulate DNA replication machinery and cell cycles in response to DNA damage and replication stress in order to prevent genomic instability and cancer. The E3 ubiquitin ligase SCFDia2 in S. cerevisiae is inv
Externí odkaz:
https://doaj.org/article/47e1c3ad3df64f63b6836000aa4ab9b0
Autor:
Rossitsa Hristova, Georgi Danovski, Anastas Gospodinov, Mila Asparuhova, Veselin Andreev, Stoyno S. Stoynov
Publikováno v:
DNA Repair. 74:38-50
Chromatin regulators play crucial roles in the DNA damage response. While the chromatin changes needed for double-strand break repair and nucleotide excision repair have been intensely studied, the chromatin requirements of interstrand crosslink (ICL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4ca8ff51b29f167a9b9d9310268ebb
https://doi.org/10.1016/j.dnarep.2018.12.007
https://doi.org/10.1016/j.dnarep.2018.12.007
SummaryWe present CellTool, a stand-alone open source software with a Graphical User Interface for image analysis, optimized for measurement of time-lapse microscopy images. It combines data management, image processing, mathematical modeling and gra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7aadba034ad74c87154ae78df968e51
https://doi.org/10.1101/454256
https://doi.org/10.1101/454256
Autor:
Stoyno S. Stoynov, Anthony A. Hyman, Radoslav Aleksandrov, Mihail Sarov, Georgi Danovski, Greta Panova, Teodora Dyankova, Stephan W. Grill, Ina Poser, Anton Dotchev, Yordan Babukov, Aneliya Ivanova, Georgi P. Georgiev, Aleksandar Atemin, Lars Hubatsch, Frank Buchholz, Dragomir B. Krastev, Susanne Hasse, Marina N. Nedelcheva-Veleva
Publikováno v:
Molecular cell. 69(6)
A single mutagen can generate multiple different types of DNA lesions. How different repair pathways cooperate in complex DNA lesions, however, remains largely unclear. Here we measured, clustered, and modeled the kinetics of recruitment and dissocia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1207938fca0ff4448138af7c15eba821
https://pubmed.ncbi.nlm.nih.gov/29547717
https://pubmed.ncbi.nlm.nih.gov/29547717
Publikováno v:
Biotechnology, Biotechnological Equipment
Secreted Phospholipases A2 (sPLA2s) represent a large family of structurally related enzymes, which target different tissues and organs and induce numerous pharmacological effects based on their catalytic specificity – hydrolysis of the sn-2 ester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e078b7a6f1c874a7ef72e615cc7f2c
https://doi.org/10.1080/13102818.2014.965014
https://doi.org/10.1080/13102818.2014.965014
Autor:
Valentina Kalichuk, Ghislaine Béhar, Axelle Renodon-Cornière, Georgi Danovski, Gonzalo Obal, Jacques Barbet, Barbara Mouratou, Frédéric Pecorari
Publikováno v:
Scientific Reports
Scientific Reports, 2016, 6, pp.37274-37274. ⟨10.1038/srep37274⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.37274-37274. ⟨10.1038/srep37274⟩
Scientific Reports, 2016, 6, pp.37274-37274. ⟨10.1038/srep37274⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.37274-37274. ⟨10.1038/srep37274⟩
International audience; The " 7 kDa DNA-binding " family, also known as the Sul7d family, is composed of chromatin proteins from the Sulfolobales archaeal order. Among them, Sac7d and Sso7d have been the focus of several studies with some characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::71653c37c714229682a61b3f7d567db9
https://doi.org/10.1038/srep37274
https://doi.org/10.1038/srep37274