Výsledky vyhledávání - "Georgette Tanner"

Akademický článek

IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy

Publikováno v: Genome Biology, Vol 25, Iss 1, Pp 1-29 (2024)

Abstract Background Glioblastoma (GBM) brain tumors lacking IDH1 mutations (IDHwt) have the worst prognosis of all brain neoplasms. Patients receive surgery and chemoradiotherapy but tumors almost always fatally recur. Results Using RNA sequencing da

Externí odkaz: https://doaj.org/article/190c474079fc465a883fccd59c89b7b7

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Akademický článek

Benchmarking pipelines for subclonal deconvolution of bulk tumour sequencing data

Autor: Georgette Tanner, David R. Westhead, Alastair Droop, Lucy F. Stead

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)

Subclonal deconvolution in cancer sequencing data is a complex task, and the optimal tools to use are unclear. Here, the authors systematically benchmark subclonal deconvolution pipelines with a comprehensive set of simulated tumour genomes and ident

Externí odkaz: https://doaj.org/article/f5475b13ac43401197d2270caf88aa9a

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IDHwt Glioblastomas Show Opposing Resistance Mechanisms Across Patients in Response to Standard Treatment

Autor: Georgette Tanner, Martina A Finetti, Steven Pollock, Nora Rippaus, Alexander-Francisco Bruns, Catherine Hogg, Alastair Droop, Anke Bruning-Richardson, Mathew Care, Joseph Wilkinson, Michael Jenkinson, Andrew Brodbelt, Aruna Chakrabarty, Azzam Ismail, Susan Short, Lucy Stead

Publikováno v: Neuro-Oncology. 24:iv1-iv1

AIMS Glioblastoma (GBM) is the most common primary malignant brain tumour in adults. Despite aggressive treatment, a resistant tumour recurs in practically all patients. We therefore aimed to better understand the mechanisms driving this treatment re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fda00d6c2c43e811d7a8638c91bb4816
https://doi.org/10.1093/neuonc/noac200.000

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Longitudinal molecular trajectories of diffuse glioma in adults

Autor: Lucy F. Stead, Daniel J. Brat, Michael D. Jenkinson, Michael Schuster, Michael Weller, Hiromichi Suzuki, Raul Rabadan, Kristin Alfaro, Do-Hyun Nam, D. Ryan Ormond, Gaetano Finocchiaro, Anzhela D. Moskalik, Hoon Kim, Jason K. Sa, Mustafa Khasraw, Chew Yee Ngan, Andrew E. Sloan, Peter Gould, Mark R. Gilbert, Ganesh Rao, Michael N. C. Fletcher, Brian L. Shaw, Houtan Noushmehr, Ketan R. Bulsara, Naema Nayyar, Elizabeth B. Claus, Colin Watts, Samirkumar B. Amin, Pim J. French, Rameen Beroukhim, Azzam Ismail, Erwin G. Van Meir, Matthew R. Grimmer, Andrew R Brodbelt, Joseph F. Costello, W. K. Alfred Yung, Susan C Short, Meihong Li, Guido Reifenberger, Adelheid Woehrer, Aruna Chakrabarty, Hui K Gan, Keith L. Ligon, Roel G.W. Verhaak, Chul-Kee Park, Simone P. Niclou, Georgette Tanner, Frederick S. Varn, Arnab Chakravarti, Javad Noorbakhsh, Floris P. Barthel, Jason T. Huse, Christoph Bock, Annette M. Molinaro, Georg Widhalm, Alexander F. Bruns, Olajide Abiola, Tathiane M. Malta, Pieter Wesseling, Tali Mazor, Donát Alpár, Peter Lichter, Jill S. Barnholtz-Sloan, Priscilla K. Brastianos, Antonio Iavarone, Laila M. Poisson, Jennifer Connelly, Bernhard Radlwimmer, Gelareh Zadeh, David M. Ashley, Ho Keung Ng, Ghazaleh Tabatabai, Peter A. E. Sillevis Smitt, Mathilde C.M. Kouwenhoven, Elizabeth J. Cochran, Jeffrey H. Chuang, Pratiti Bandopadhayay, Kevin C. Johnson, Marion Smits, Allison Lowman, John de Groot, Kevin J. Anderson, Johanna M. Niers, Bart A. Westerman, Peter S. LaViolette, Emre Kocakavuk, Kenneth Aldape, Kerrie L. McDonald

Publikováno v: Nature, vol 576, iss 7785
Nature, 576(7785), 112-120. Nature Publishing Group
Nature
Barthel, F P, Johnson, K C, Varn, F S, Moskalik, A D, Tanner, G, Kocakavuk, E, Anderson, K J, Abiola, O, Aldape, K, Alfaro, K D, Alpar, D, Amin, S B, Ashley, D M, Bandopadhayay, P, Barnholtz-Sloan, J S, Beroukhim, R, Bock, C, Brastianos, P K, Brat, D J, Brodbelt, A R, Bruns, A F, Bulsara, K R, Chakrabarty, A, Chakravarti, A, Chuang, J H, Claus, E B, Cochran, E J, Connelly, J, Costello, J F, Finocchiaro, G, Fletcher, M N, French, P J, Gan, H K, Gilbert, M R, Gould, P V, Grimmer, M R, Iavarone, A, Ismail, A, Jenkinson, M D, Khasraw, M, Kim, H, Kouwenhoven, M C M, LaViolette, P S, Li, M, Lichter, P, Ligon, K L, Lowman, A K, Malta, T M, Mazor, T, McDonald, K L, Molinaro, A M, Nam, D H, Nayyar, N, Ng, H K, Ngan, C Y, Niclou, S P, Niers, J M, Noushmehr, H, Noorbakhsh, J, Ormond, D R, Park, C K, Poisson, L M, Rabadan, R, Radlwimmer, B, Rao, G, Reifenberger, G, Sa, J K, Schuster, M, Shaw, B L, Short, S C, Smitt, P A S, Sloan, A E, Smits, M, Suzuki, H, Tabatabai, G, Van Meir, E G, Watts, C, Weller, M, Wesseling, P, Westerman, B A, Widhalm, G, Woehrer, A, Yung, W K A, Zadeh, G, Huse, J T, De Groot, J F, Stead, L F, Verhaak, R G W & The GLASS Consortium 2019, ' Longitudinal molecular trajectories of diffuse glioma in adults ', Nature, vol. 576, no. 7785, pp. 112-120 . https://doi.org/10.1038/s41586-019-1775-1, https://doi.org/10.1038/s41586-019-1775-1

The evolutionary processes that drive universal therapeutic resistance in adult patients with diffuse glioma remain unclear1,2. Here we analysed temporally separated DNA-sequencing data and matched clinical annotation from 222 adult patients with gli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42aa714cc58ed5e72980caca94e04350
https://pure.eur.nl/en/publications/b9198630-2a42-471b-be97-3c7b0986e7d4

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Decreasing formalin concentration improves quality of DNA extracted from formalin-fixed paraffin-embedded tissue specimens without compromising tissue morphology or immunohistochemical staining

Autor: Narinder Gahir, James Hurst, Olorunda Rotimi, Katie Allen, Nicolas M. Orsi, Zara Farooq, Leah Khazin, Phillip Thompson, Henry King, Georgette Tanner, Keyura Raveendran, Allan Gray, Caroline Cartlidge, Michele Cummings

Publikováno v: Journal of clinical pathology. 73(8)

Genomic technologies are increasingly used clinically for both diagnosis and guiding cancer therapy. However, formalin fixation can compromise DNA quality. This study aimed to optimise tissue fixation using normal colon, liver and uterus (n=8 each) b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cedaaade527c3a107944ac621ae2e1b
https://pubmed.ncbi.nlm.nih.gov/31919142

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GENE-28. LONGITUDINAL MOLECULAR TRAJECTORIES OF DIFFUSE GLIOMA IN ADULTS

Autor: Kevin W. Anderson, Anzhela D. Moskalik, Olajide Abiola, Lucy F. Stead, John DeGroot, Kevin C. Johnson, Roel G.W. Verhaak, Emre Kocakavuk, Jason T. Huse, Georgette Tanner, Floris P. Barthel, Frederick S. Varn

Publikováno v: Neuro Oncol

Treatment options for adult patients with glioma has remained largely unchanged over the past three decades. Targeted inhibitors and immunotherapies have improved outcomes for many cancer types but their relevance in glioma is unclear. The inevitabil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346816cc3a28d4dfb880aaf44ac9aeea
https://europepmc.org/articles/PMC6847692/

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