Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Georgette Howard"'
Publikováno v:
Journal of Pharmacy and Pharmacology. 53:1365-1371
The purpose of this study was to determine if changes in nuclear protein binding of hepatocyte nuclear factor 1 (HNF-1) occur after lipopolysaccharide (LPS) administration. In addition, the time-course of alterations in CYP2E1 regulation were evaluat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c364972949c942571f4133fa8f81f3
https://doi.org/10.1211/0022357011777864
https://doi.org/10.1211/0022357011777864
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 13:63-69
Endotoxin exposure elicits various responses in mammals including the acute phase response that has been shown to cause changes in the activity of several forms of cytochrome P450s and other enzymes. Therefore, the hepatic conjugating enzyme, glutath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d90980316000a185450ea13f30b1a6ec
https://doi.org/10.1002/(sici)1099-0461(1999)13:2<63::aid-jbt1>3.0.co
https://doi.org/10.1002/(sici)1099-0461(1999)13:2<63::aid-jbt1>3.0.co
Publikováno v:
Life Sciences. 63:1339-1346
There is evidence to suggest that obese populations have an increased susceptibility to various pathologic disorders. Both AP-1 and STAT nuclear binding proteins have been suggested to play a role in certain obesity-related diseases. The objective of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b096012d6405550afffae702ff5371
https://doi.org/10.1016/s0024-3205(98)00397-x
https://doi.org/10.1016/s0024-3205(98)00397-x
Autor:
Graham W. Warren, Amy L. Roe, Guoqiang Hou, Steven I. Shedlofsky, Robert A. Blouin, Georgette Howard
Publikováno v:
Pharmaceutical Research. 15:1603-1608
Purpose. The purpose of our research was two-fold: 1) to further characterize the downregulation of CYP3A2 mRNA, protein, and activity during an acute phase response (APR); 2) most importantly, to relate the time-dependent activation of nuclear prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b2decc6e9c8b13195dfd8f65f0df642
https://doi.org/10.1023/a:1011915402914
https://doi.org/10.1023/a:1011915402914
Publikováno v:
Endocrinology. 138:4649-4656
Regulation of galanin gene expression in the anterior pituitary (AP) is positively influenced by estrogen in rodents and undetermined in humans. The objective of this study was to investigate the mechanism behind estrogen induction of galanin by iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76ecf1c196bdcf628fed8c5be002471
https://doi.org/10.1210/endo.138.11.5507
https://doi.org/10.1210/endo.138.11.5507
Publikováno v:
Biochemical and Biophysical Research Communications. 228:110-114
Phenobarbital (PB) is a potent inducer of cytochrome P450 enzymes, particularly CYP2B1/2B2. Although the mechanism(s) of PB induction of CYP2B1/2B2 is not fully understood, current research is focusing on the role PB may play in altering the binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede200b600a6b5c1e75e7a0cd9fb0907
https://doi.org/10.1006/bbrc.1996.1624
https://doi.org/10.1006/bbrc.1996.1624
Autor:
Samuel C. Keeble, Georgette Howard, Kenneth N. Muse, James F. Hyde, Thomas E. Curry, Steve N. London, M D Fox
Publikováno v:
Endocrinology. 135:636-641
Galanin is a 29-amino acid peptide that acts as a neuropeptide in many tissues. To date, galanin action and the hormonal regulation of galanin gene expression have not been described in the ovary of any species. To study possible ovarian expression a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8cc3c7ccd7ab3210b264a1761fd3114
https://doi.org/10.1210/endo.135.2.7518387
https://doi.org/10.1210/endo.135.2.7518387
Publikováno v:
Endocrinology. 133:2588-2593
The peptide galanin is synthesized within and secreted from specific cell types of the rat anterior pituitary gland. The small size of the rat anterior pituitary gland is somewhat limiting for studying the regulation of galanin gene expression and pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f7797b69b31be0f9950c6f9af25e2d
https://doi.org/10.1210/endo.133.6.7694842
https://doi.org/10.1210/endo.133.6.7694842
Publikováno v:
Journal of Neuroendocrinology. 4:449-454
Estrogen dramatically increases galanin mRNA and peptide levels in the rat anterior pituitary gland. We recently reported that galanin secretion in vitro from estrogen-exposed anterior pituitary cells is regulated by hypothalamic factors; dopamine an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e259bea47ee3babbdfc6d3cc90f3b1
https://doi.org/10.1111/j.1365-2826.1992.tb00192.x
https://doi.org/10.1111/j.1365-2826.1992.tb00192.x
Publikováno v:
Molecular and Cellular Biology. 11:4423-4430
Enhancer/promoter elements from two pancreas-specific genes, those encoding amylase and elastase, were ligated to the bacterial GPT gene. The resulting construct can be used to select for expression of gene products which activate these pancreas-spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6d656ccf5e58a4ea4f081d432540e9
https://doi.org/10.1128/mcb.11.9.4423-4430.1991
https://doi.org/10.1128/mcb.11.9.4423-4430.1991