Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Georgette D. Kanmogne"'
Publikováno v:
Cells, Vol 13, Iss 17, p 1415 (2024)
Blood–brain barrier (BBB) injury and dysfunction following infection with the human immunodeficiency virus (HIV) enables viral entry into the brain, infection of resident brain cells, neuronal injury and subsequent neurodegeneration leading to HIV-
Externí odkaz:
https://doaj.org/article/548ceff0acc94cb5b00156848f5d3cee
Autor:
Georgette D. Kanmogne
Publikováno v:
Cells, Vol 13, Iss 8, p 672 (2024)
Endothelial cell activation, injury, and dysfunction underlies the pathophysiology of vascular diseases and infections associated with vascular dysfunction, including human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome. Despite
Externí odkaz:
https://doaj.org/article/5458c0e3ccb34ca987cd40283795bd09
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-23 (2021)
Abstract Background Neurocognitive impairment is present in 50% of HIV-infected individuals and is often associated with Alzheimer’s Disease (AD)-like brain pathologies, including increased amyloid-beta (Aβ) and Tau hyperphosphorylation. Here, we
Externí odkaz:
https://doaj.org/article/705f4ddd754e462280ef57c697fc0713
Autor:
Brady Sillman, Aditya N. Bade, Prasanta K. Dash, Biju Bhargavan, Ted Kocher, Saumi Mathews, Hang Su, Georgette D. Kanmogne, Larisa Y. Poluektova, Santhi Gorantla, JoEllyn McMillan, Nagsen Gautam, Yazen Alnouti, Benson Edagwa, Howard E. Gendelman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Current ART for treatment of HIV-1 infection requires a strict daily regimen adherence. Herein, the authors report the manufacture and characterization of a nanoformulated dolutegravir prodrug with improved cell and tissue penetration, a remarkable a
Externí odkaz:
https://doaj.org/article/9fe938444e464eaea1e85845549ff241
Publikováno v:
Data in Brief, Vol 6, Iss , Pp 345-351 (2016)
In the present article, using human monocyte-derived macrophages and cell lines containing integrated copies of the HIV-1 promoter, we show the effects of TLR3 ligands on the pro-inflammatory cytokine IL-6. We further show the effects of TLR3 ligands
Externí odkaz:
https://doaj.org/article/59a7556f149b4a64b7b6c8b4fd731f95
Autor:
Georges Teto, Julius Y. Fonsah, Claude T. Tagny, Dora Mbanya, Emilienne Nchindap, Leopoldine Kenmogne, Joseph Fokam, Dora M. Njamnshi, Charles Kouanfack, Alfred K. Njamnshi, Georgette D. Kanmogne
Publikováno v:
Viruses, Vol 8, Iss 7, p 196 (2016)
HIV-1 Tat plays a critical role in viral transactivation. Subtype-B Tat has potential use as a therapeutic vaccine. However, viral genetic diversity and population genetics would significantly impact the efficacy of such a vaccine. Over 70% of the 37
Externí odkaz:
https://doaj.org/article/a3d2fba88e5e4a84ae528668b4dcadb3
Autor:
Biju Bhargavan, Georgette D. Kanmogne
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10436
In SARS-CoV-2-infected humans, disease progression is often associated with acute respiratory distress syndrome involving severe lung injury, coagulopathy, and thrombosis of the alveolar capillaries. The pathogenesis of these pulmonary complications
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-23 (2021)
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-23 (2021)
Background Neurocognitive impairment is present in 50% of HIV-infected individuals and is often associated with Alzheimer’s Disease (AD)-like brain pathologies, including increased amyloid-beta (Aβ) and Tau hyperphosphorylation. Here, we aimed to
Publikováno v:
AIDS Res Hum Retroviruses
Variations in the HIV genome influence HIV/AIDS epidemiology. We report here a novel HIV-1 unique recombinant form (URF) isolated from an HIV-infected female (NACMR092) in Cameroon, based on the analyses of near-full-length viral genome (partial gag,
Autor:
Biju Bhargavan, Georgette D. Kanmogne
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Scientific Reports
Scientific Reports
HIV subtypes distribution varies by geographic regions; this is likely associated with differences in viral fitness but the predictors and underlying mechanisms are unknown. Using in-vitro, in-vivo, and ex-vivo approaches, we found significantly high