Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Georgeta Teodorescu"'
Autor:
Georgeta Teodorescu, Han-Shen Tae, A. Marie Phillips, Steven Petrou, Holger Lerche, Christopher A. Reid, Kerstin Hallmann, Ailing A. Kleefuss-Lie, Snezana Maljevic, Wolfram S. Kunz, Christian E. Elger, Felicitas Becker, Yvonne G. Weber, Edward Perez-Reyes
Publikováno v:
Epilepsia Open
Summary Objective Genetic generalized epilepsy (GGE) encompasses seizure disorders characterized by spike‐and‐wave discharges (SWD) originating within thalamo‐cortical circuits. Hyperpolarization‐activated (HCN) and T‐type Ca2+ channels are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fcf6348dfbac5fe09717a934f6ea39f
http://europepmc.org/articles/PMC5862120
http://europepmc.org/articles/PMC5862120
Autor:
Mohammad R. Toliat, Gabriel Stölting, Georgeta Teodorescu, Holger Lerche, Birgit Begemann, Peter Nürnberg, Julian Schubert, Christoph Fahlke, Thomas Sander, Rima Nabbout
Publikováno v:
Pflugers Archiv
Pflügers Archiv 465(10), 1423-1437 (2013). doi:10.1007/s00424-013-1286-0
Pflügers Archiv 465(10), 1423-1437 (2013). doi:10.1007/s00424-013-1286-0
ClC-2 is a voltage-dependent chloride channel that activates slowly at voltages negative to the chloride reversal potential. Adenosine triphosphate (ATP) and other nucleotides have been shown to bind to carboxy-terminal cystathionine-ß-synthase (CBS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c214d9f0b7dc33960ba97d1b16daa222
http://europepmc.org/articles/PMC3778897
http://europepmc.org/articles/PMC3778897
Autor:
Heike Wulff, Yingliang Wu, Violeta Visan, Stéphanie Mouhat, Michel De Waard, Stephan Grissmer, Daniel Homerick, Hervé Darbon, Jean-Marc Sabatier, Georgeta Teodorescu
Publikováno v:
Molecular Pharmacology
Molecular Pharmacology, 2006, 69 (1), pp.354-62. ⟨10.1124/mol.105.017210⟩
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2006, 69 (1), pp.354-62. ⟨10.1124/mol.105.017210⟩
Molecular Pharmacology, 2006, 69 (1), pp.354-62. ⟨10.1124/mol.105.017210⟩
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2006, 69 (1), pp.354-62. ⟨10.1124/mol.105.017210⟩
International audience; OSK1, a toxin from the venom of the Asian scorpion Orthochirus scrobiculosus, is a 38-residue peptide cross-linked by three disulfide bridges. A structural analog of OSK1, [Lys(16),Asp(20)]-OSK1, was found previously to be one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfdc8553ff6b630a7906071fac25fe10
https://doi.org/10.1124/mol.105.017210
https://doi.org/10.1124/mol.105.017210
Autor:
Holger Lerche, Georgeta Teodorescu, Cécile Saint-Martin, Eric LeGuern, Gregory Gauvain, Jean Christophe Poncer, Christoph Fahlke, Jennie Garcia-Olivares, Isabelle Gourfinkel-An, Rima Nabbout, Yvonne G. Weber, Snezana Maljevic, Christel Depienne, Estelle Fedirko, Jan-Peter Ernst
Publikováno v:
Human mutation. 30(3)
Heterozygous mutations in the CLCN2 gene encoding the voltage-gated chloride channel CLC2 have been identified in patients with idiopathic generalized epilepsy (IGE). Yet the involvement of CLCN2 in epilepsy remains controversial. To investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1c7c1f2893344a3d32e624ac029bab
https://pubmed.ncbi.nlm.nih.gov/19191339
https://pubmed.ncbi.nlm.nih.gov/19191339
Autor:
Georgeta Teodorescu, Joachim Spiess, Stephan Grissmer, Amalia M. Dolga, Thomas Blank, Ingrid M. Nijholt, Saravana R. K. Murthy
Publikováno v:
Journal of Neurochemistry, 106(6), 2312-2321. Blackwell Publishing Ltd
Throughout the CNS, small conductance Ca(2+)-activated potassium (SK) channels modulate firing frequency and neuronal excitability. We have identified a novel, shorter isoform of standard SK2 (SK2-std) in mouse brain which we named SK2-sh. SK2-sh is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bab47cac225beb75a29e9c35d2d031
https://research.rug.nl/en/publications/0fa973c6-64ce-4644-8576-9478b51b4209
https://research.rug.nl/en/publications/0fa973c6-64ce-4644-8576-9478b51b4209
Publikováno v:
Molecular pharmacology. 69(4)
Potassium channels play fundamental roles in physiology. Chemically diverse drugs bind in the pore region of K+ channels. Here, we homology-modeled voltage- and Ca2+-gated K+ channel BK and voltage-gated Kv1.3 using the X-ray structures of MthK and K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41e0ea18d3859e84546888c71a6c21c
https://pubmed.ncbi.nlm.nih.gov/16391240
https://pubmed.ncbi.nlm.nih.gov/16391240