Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Georges Orfanoudakis"'
Autor:
Changqing Li, Stefano Moro, Kateryna Shostak, Francis J. O’Reilly, Mariel Donzeau, Andrea Graziadei, Alastair G. McEwen, Dominique Desplancq, Pierre Poussin-Courmontagne, Thomas Bachelart, Mert Fiskin, Nicolas Berrodier, Simon Pichard, Karl Brillet, Georges Orfanoudakis, Arnaud Poterszman, Vladimir Torbeev, Juri Rappsilber, Norman E. Davey, Alain Chariot, Katia Zanier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The inhibitor of κB (IκB) kinase (IKK) is a central regulator of NF-κB signaling. All IKK complexes contain hetero- or homodimers of the catalytic IKKβ and/or IKKα subunits. Here, we identify a YDDΦxΦ motif, which is conserved in subs
Externí odkaz:
https://doaj.org/article/7002b32fa22e4bd38f05d9ec9d049537
Autor:
Xavier Bernard, Philip Robinson, Yves Nominé, Murielle Masson, Sebastian Charbonnier, Juan Ramon Ramirez-Ramos, Francois Deryckere, Gilles Travé, Georges Orfanoudakis
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25981 (2011)
The E6 oncoprotein produced by high-risk mucosal HPV stimulates ubiquitinylation and proteasome-dependent degradation of the tumour suppressor p53 via formation of a trimeric complex comprising E6, p53, and E6-AP. p53 is also degraded by its main cel
Externí odkaz:
https://doaj.org/article/3da0520cc73a4949ab70ead7b537c878
Autor:
D. Tsakogiannis, P. Gortsilas, T.G. Dimitriou, Panayotis Markoulatos, Georges Orfanoudakis, Z. Kyriakopoulou, I. G. A. Ruether
Publikováno v:
Journal of Medical Virology. 87:1973-1980
Integration of HPV16 DNA into the host chromosome usually disrupts the E1 and/or E2 genes. The present study investigated the disruption of E1, E2 genes in a total of eighty four HPV16-positive precancerous and cervical cancer specimens derived from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbfaaaf344c993b1f8dbfa2c659f9c53
https://doi.org/10.1002/jmv.24256
https://doi.org/10.1002/jmv.24256
Autor:
Panayotis Markoulatos, F. Darmis, I. G. A. Ruether, E. Panotopoulou, D. Tsakogiannis, Georges Orfanoudakis, Z. Kyriakopoulou, T.G. Dimitriou
Publikováno v:
Journal of Medical Virology. 86:778-784
Recent studies have focused on sequence variation of the HPV16 E1 gene. The present study investigates the prevalence of E1-1374^63nt duplication in the Greek population, and the sequence variation at the 5′ end of the E1 and E6 genes from samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34bb7bc289b2c9ffeb2399ebe3e0fda6
https://doi.org/10.1002/jmv.23896
https://doi.org/10.1002/jmv.23896
Autor:
Penelope Mavromara, Bruno Kieffer, Yves Nominé, Gilles Travé, Niki Vassilaki, Georges Orfanoudakis, Anissa Boumlic, Georgia Dalagiorgou, Sebastian Charbonnier
Publikováno v:
FEBS Journal. 277:774-789
The hepatitis C virus (HCV) Core+1/S polypeptide, also known as alternative reading frame protein (ARFP)/S, is an ARFP expressed from the Core coding region of the viral genome. Core+1/S is expressed as a result of internal initiation at AUG codons (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::185716fcaf8afa59a9c20edd0a77de01
https://doi.org/10.1111/j.1742-4658.2009.07527.x
https://doi.org/10.1111/j.1742-4658.2009.07527.x
Autor:
Georges Orfanoudakis, Laurent Mailly, Etienne Weiss, Magali Lagrange, Charlotte Boulade-Ladame, François Deryckere
Publikováno v:
Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2007, 361 (2), pp.487-92. ⟨10.1016/j.bbrc.2007.07.040⟩
Biochemical and Biophysical Research Communications, Elsevier, 2007, 361 (2), pp.487-92. ⟨10.1016/j.bbrc.2007.07.040⟩
The E6 protein of human papillomavirus type 16 (16E6) is involved in the tumorigenesis of human cervical cells by targeting numerous cellular proteins. We have designed a strategy for neutralizing 16E6 based on the intracellular expression of single-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272c11fac40ca187efd38a0c53f43454
https://doi.org/10.1016/j.bbrc.2007.07.040
https://doi.org/10.1016/j.bbrc.2007.07.040
Autor:
Philip R. Tedbury, Georges Orfanoudakis, Denise Stuber, François Deryckere, Magali Lagrange, Philip Robinson
Publikováno v:
Journal of Molecular Recognition. 18:175-182
'High-risk' human papilloma viruses (HPVs) cause cervical tumours. In order to treat these tumours therapeutic approaches must be developed that efficiently target the tumour cells. Using phage display, we selected tumour-targeting peptides from a li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8463b5dce2d89618642832757dee6176
https://doi.org/10.1002/jmr.723
https://doi.org/10.1002/jmr.723
Autor:
Claude Granier, Laurence Choulier, Danièle Altschuh, Myriam Ben Khalifa, Etienne Weiss, Daniel Laune, Philippe Robinson, Georges Orfanoudakis
Publikováno v:
Journal of Immunological Methods
Journal of Immunological Methods, Elsevier, 2002, 259 (1-2), pp.77-86. ⟨10.1016/S0022-1759(01)00496-3⟩
Journal of Immunological Methods, Elsevier, 2002, 259 (1-2), pp.77-86
Journal of Immunological Methods, Elsevier, 2002, 259 (1-2), pp.77-86. ⟨10.1016/S0022-1759(01)00496-3⟩
Journal of Immunological Methods, Elsevier, 2002, 259 (1-2), pp.77-86
The linear epitope recognized by three closely related antibodies specific for the E6 oncoprotein of papillomavirus type 16 was delineated by phage display, spot peptide synthesis on cellulose membranes, and kinetic measurements with antigenic varian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028422a92ade0866af4c4860cea787f0
https://doi.org/10.1016/s0022-1759(01)00496-3
https://doi.org/10.1016/s0022-1759(01)00496-3
Autor:
G. Kontostathi, I. G. A. Ruether, Georges Orfanoudakis, Z. Kyriakopoulou, Panayotis Markoulatos, T.G. Dimitriou, A. Papadopoulou, D. Tsakogiannis
Publikováno v:
Journal of Medical Microbiology
Journal of Medical Microbiology, Society for General Microbiology, 2013, 62 (11), pp.1688-1696. ⟨10.1099/jmm.0.055491-0⟩
Journal of Medical Microbiology, Society for General Microbiology, 2013, 62 (11), pp.1688-1696. ⟨10.1099/jmm.0.055491-0⟩
Human papillomavirus type 16 (HPV16) non-European variants have been associated with persistent infection and cervical cancer development, while the L83V variant of the E6 gene has been correlated with the progression of cervical malignancy. The pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4a57ac87855a0c93fd4d0f8984ddcb
https://hal.archives-ouvertes.fr/hal-02975711
https://hal.archives-ouvertes.fr/hal-02975711
Publikováno v:
Protein Expression and Purification. 5:509-517
We describe a novel vector system suitable for the efficient preparation of in vivo biotinylated antibody Fab fragments in Escherichia coli. The previously described pGE20 vector used for the functional expression of truncated heavy (Fd) and light (L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab04c3fc1d97bd3eab3a97168ba694b
https://doi.org/10.1006/prep.1994.1070
https://doi.org/10.1006/prep.1994.1070