Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Georges N. Kanaan"'
Autor:
Georges N. Kanaan, Bianca Ichim, Lara Gharibeh, Wael Maharsy, David A. Patten, Jian Ying Xuan, Arkadiy Reunov, Philip Marshall, John Veinot, Keir Menzies, Mona Nemer, Mary-Ellen Harper
Publikováno v:
Redox Biology, Vol 14, Iss , Pp 509-521 (2018)
Glutaredoxin 2 (GRX2), a mitochondrial glutathione-dependent oxidoreductase, is central to glutathione homeostasis and mitochondrial redox, which is crucial in highly metabolic tissues like the heart. Previous research showed that absence of Grx2, le
Externí odkaz:
https://doaj.org/article/79e5600b7586451baac3f02ec5dd3f77
Autor:
Gedaliah Farber, Liyong Zhang, Youan Liu, Dana J. Philpott, Fayez Dawood, Yena Oh, Kyoung-Han Kim, Alan Valaperti, Benjamin H. Rotstein, Peter P. Liu, Guo Hua Li, David Smyth, Mark Moon, Georges N. Kanaan, Wenbin Liang, Han-Bin Lin, Mary-Ellen Harper, Kotaro Naito
Publikováno v:
Circulation
Background: Cardiac hypertrophy is a key biological response to injurious stresses such as pressure overload and, when excessive, can lead to heart failure. Innate immune activation by danger signals, through intracellular pattern recognition recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1857ac0fdb5191d3ed6b0954615f5ae9
https://doi.org/10.1161/circulationaha.119.041213
https://doi.org/10.1161/circulationaha.119.041213
Autor:
Sandrine Parent, Mary-Ellen Harper, Ghazaleh Rafatian, Pushpinder Kanda, Connor Michie, Melanie Villanueva, Darryl R. Davis, Bin Ye, Georges N. Kanaan, Wenbin Liang
Publikováno v:
Theranostics
Decades of work have shown that diabetes increases the risk of heart disease and worsens clinical outcomes after myocardial infarction. Because diabetes is an absolute contraindication to heart transplant, cell therapy is increasingly being explored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e76016404e8d6dcb8465b95e29f7be2
http://europepmc.org/articles/PMC6735395
http://europepmc.org/articles/PMC6735395
Autor:
Lara Gharibeh, David A. Patten, John P. Veinot, Philip L. Marshall, Bianca Ichim, Wael Maharsy, Keir J. Menzies, Arkadiy Reunov, Mary-Ellen Harper, Mona Nemer, Jian Ying Xuan, Georges N. Kanaan
Publikováno v:
Redox Biology, Vol 14, Iss, Pp 509-521 (2018)
Redox Biology
Redox Biology
Glutaredoxin 2 (GRX2), a mitochondrial glutathione-dependent oxidoreductase, is central to glutathione homeostasis and mitochondrial redox, which is crucial in highly metabolic tissues like the heart. Previous research showed that absence of Grx2, le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed92f74eb9f070ad4ad047a64aaa8753
https://doi.org/10.1016/j.redox.2017.10.019
https://doi.org/10.1016/j.redox.2017.10.019
Autor:
Georges N. Kanaan, Mary-Ellen Harper
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1861:2822-2829
To meet its exceptionally high energy demands, the heart relies largely on fatty acid oxidation, which then drives the oxidative phosphorylation system in mitochondria. Each day, this system produces about 6kg of ATP to sustain heart function. Fatty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99208442540789c19d592fabc47fbfc9
https://doi.org/10.1016/j.bbagen.2017.07.027
https://doi.org/10.1016/j.bbagen.2017.07.027
Publikováno v:
Canadian journal of diabetes. 43(1)
Objectives Type 2 diabetes mellitus is a chronic progressive disease that is associated with increased risk for cardiovascular diseases and with impaired mitochondrial metabolism in cardiac and skeletal muscles. Atrial fibrillation (AF) is the most c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45914d603193b6c5d13c46788b5c137
https://pubmed.ncbi.nlm.nih.gov/30146472
https://pubmed.ncbi.nlm.nih.gov/30146472
Autor:
Mary-Elizabeth Patti, Brittany Beauchamp, Alexandre Blais, Karunanithi Rajamanickam, Mary-Ellen Harper, Georges N. Kanaan, Eve C. Tsai, Alphonse Chu, Sujoy Ghosh, Michael Dysart
Publikováno v:
International journal of obesity (2005)
Background In utero undernutrition is associated with obesity and insulin resistance, although its effects on skeletal muscle remain poorly defined. Therefore, in the current study we explored the effects of in utero food restriction on muscle energy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde4e86d473da0538ee1ac044ce5c218
https://doi.org/10.1038/ijo.2014.120
https://doi.org/10.1038/ijo.2014.120