Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Georges Mairet-Coello"'
Autor:
Jerome Clasadonte, Tania Deprez, Gabriel S. Stephens, Georges Mairet-Coello, Pierre-Yves Cortin, Maxime Boutier, Aurore Frey, Jeannie Chin, Marek Rajman
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2024)
Activity induced transcription factor ΔFosB plays a key role in different CNS disorders including epilepsy, Alzheimer’s disease, and addiction. Recent findings suggest that ΔFosB drives cognitive deficits in epilepsy and together with the emergen
Externí odkaz:
https://doaj.org/article/d2dd9f4f1f4540508a2b8550c0ff6076
Autor:
Annie Lee, Chandana Kondapalli, Daniel M. Virga, Tommy L. Lewis, So Yeon Koo, Archana Ashok, Georges Mairet-Coello, Sebastien Herzig, Marc Foretz, Benoit Viollet, Reuben Shaw, Andrew Sproul, Franck Polleux
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Loss of excitatory synapses occur prior to the formation of amyloid plaques in Alzheimer’s disease. Here the authors show in an animal model that the loss of synapses induced by amyloid-beta oligomers requires over-activation of a stress-response p
Externí odkaz:
https://doaj.org/article/e4cca8864343441c862cd2169b11e9ee
Autor:
Prashant K. Srivastava, Jonathan van Eyll, Patrice Godard, Manuela Mazzuferi, Andree Delahaye-Duriez, Juliette Van Steenwinckel, Pierre Gressens, Benedicte Danis, Catherine Vandenplas, Patrik Foerch, Karine Leclercq, Georges Mairet-Coello, Alvaro Cardenas, Frederic Vanclef, Liisi Laaniste, Isabelle Niespodziany, James Keaney, Julien Gasser, Gaelle Gillet, Kirill Shkura, Seon-Ah Chong, Jacques Behmoaras, Irena Kadiu, Enrico Petretto, Rafal M. Kaminski, Michael R. Johnson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The identification of new drug targets is highly challenging, particularly for diseases of the brain. This study describes a general computational gene regulatory framework called CRAFT for drug target discovery, and the authors use CRAFT to identify
Externí odkaz:
https://doaj.org/article/c0cffc3635504945bbe2f39f8175da2f
Autor:
Charlotte Bouckaert, Charlotte Germonpré, Jeroen Verhoeven, Seon-Ah Chong, Lucas Jacquin, Georges Mairet-Coello, Véronique Marie André, Karine Leclercq, Christian Vanhove, Filip De Vos, Caroline Van den Broecke, Ingeborg Goethals, Benedicte Descamps, Sam Donche, Evelien Carrette, Wytse Wadman, Paul Boon, Kristl Vonck, Robrecht Raedt
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 6999 (2020)
Seizures are common in patients with high-grade gliomas (30–60%) and approximately 15–30% of glioblastoma (GB) patients develop drug-resistant epilepsy. Reliable animal models are needed to develop adequate treatments for glioma-related epilepsy.
Externí odkaz:
https://doaj.org/article/477dcffe04e7468e8c740ef11801806e
Autor:
Guillaume Becker, Tania Deprez, Mohamed Ali Bahri, Alain Plenevaux, Fabian Hustadt, Christian Lemaire, Georges Mairet-Coello, Anne Michel, Catherine De Wolf, Lucas Jacquin, Eric Gillent, Aline Freyssin, Martin Citron, Erwan Bezard, Mélina Caruso, Jean-Marie Frequin, André Luxen, Gaëtan Garraux, Patrick Downey
Publikováno v:
Neurobiology of Aging. 107:142-152
With the emergence of disease-modifying therapies for Parkinson's disease, reliable longitudinal markers are needed to quantify pathology and demonstrate disease progression. We developed the A53T-AAV rat model of synucleinopathy by combining longitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2d97855b19689590e7d238ba49b7a74
https://doi.org/10.1016/j.neurobiolaging.2021.07.012
https://doi.org/10.1016/j.neurobiolaging.2021.07.012
Autor:
Pamela Maher, Karine Leclercq, Tania Deprez, Hideyo Sato, Ilse Julia Smolders, Rafal M. Kaminski, Catherine Vandenplas, Sylvia Dardenne, Seon-Ah Chong, Patrik Foerch, Ann Massie, Georges Mairet-Coello, Joeri Van Liefferinge, Giulia Albertini, Eduard Bentea, Michel Neveux
Publikováno v:
Epilepsia. 60:1412-1423
Objective The cystine/glutamate antiporter system x c - could represent a new target for antiepileptogenic treatments due to its crucial roles in glutamate homeostasis and neuroinflammation. To demonstrate this, we compared epilepsy development and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b0e6a73024aef0e3e67e42b1c41e1c
https://doi.org/10.1111/epi.16055
https://doi.org/10.1111/epi.16055
Autor:
Annie Lee, Chandana Kondapalli, Daniel M. Virga, Tommy L. Lewis, So Yeon Koo, Archana Ashok, Georges Mairet-Coello, Sebastien Herzig, Marc Foretz, Benoit Viollet, Reuben Shaw, Andrew Sproul, Franck Polleux
Publikováno v:
Nature Communications
Nature Communications, 2022, 13 (1), pp.4444. ⟨10.1038/s41467-022-32130-5⟩
Nature Communications, 2022, 13 (1), pp.4444. ⟨10.1038/s41467-022-32130-5⟩
During the early stages of Alzheimer’s disease (AD) in both mouse models and human patients, soluble forms of Amyloid-β 1–42 oligomers (Aβ42o) trigger loss of excitatory synapses (synaptotoxicity) in cortical and hippocampal pyramidal neurons (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460af2ea012485e058110bf60eec2fce
https://pubmed.ncbi.nlm.nih.gov/35915085
https://pubmed.ncbi.nlm.nih.gov/35915085
Autor:
Jeroen Verhoeven, Caroline Van den Broecke, Seon-Ah Chong, Karine Leclercq, Christian Vanhove, Charlotte Germonpré, Lucas Jacquin, Ingeborg Goethals, Wytse Wadman, Kristl Vonck, Véronique M. André, Charlotte Bouckaert, Paul Boon, Benedicte Descamps, Robrecht Raedt, Evelien Carrette, Sam Donche, Filip De Vos, Georges Mairet-Coello
Publikováno v:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
International Journal of Molecular Sciences
Volume 21
Issue 19
International Journal of Molecular Sciences, Vol 21, Iss 6999, p 6999 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 19
International Journal of Molecular Sciences, Vol 21, Iss 6999, p 6999 (2020)
Seizures are common in patients with high-grade gliomas (30&ndash
60%) and approximately 15&ndash
30% of glioblastoma (GB) patients develop drug-resistant epilepsy. Reliable animal models are needed to develop adequate treatments for glioma
60%) and approximately 15&ndash
30% of glioblastoma (GB) patients develop drug-resistant epilepsy. Reliable animal models are needed to develop adequate treatments for glioma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd595d7d20820a53738017bdec2764d7
https://biblio.ugent.be/publication/8675526
https://biblio.ugent.be/publication/8675526
Autor:
Berni Sweeney, Marta Westwood, Kerry Louise Tyson, David McMillan, Geofrey Odede, Gillian Burgess, Terry Baker, Daniel John Lightwood, Patrick Downey, Georges Mairet-Coello, Rebecca Munro, Martin Citron, Robert G. Griffin, Dale Starkie, Marie-Laetitia Mushikiwabo, Nathalie Pacico, Ruodan Nan, Sophie Jung, Rachel Angers, Jean-Philippe Courade, Andrew George Popplewell
Publikováno v:
Acta Neuropathologica
In Alzheimer’s disease (AD) and other tauopathies, the cytosolic protein Tau misfolds and forms intracellular aggregates which accumulate within the brain leading to neurodegeneration. Clinical progression is tightly linked to the progressive sprea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67c24541a714f957c1f3282bf1205ce
https://doi.org/10.1007/s00401-018-1911-2
https://doi.org/10.1007/s00401-018-1911-2
Autor:
Jean-Philippe Courade, Joël Mercier, Michel Gillard, Jonas Hannestad, Delphine Viot, Georges Mairet-Coello, Martin Citron, Philippe Motte, Celine Vermeiren
Publikováno v:
Movement Disorders. 33:273-281
BACKGROUND Lilly/Avid's AV-1451 is one of the most advanced tau PET tracers in the clinic. Although results obtained in Alzheimer's disease patients are compelling, discrimination of tracer uptake in healthy individuals and patients with supranuclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4c262809f637fecd05b7537fc44b16
https://doi.org/10.1002/mds.27271
https://doi.org/10.1002/mds.27271