Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Georges Hirth"'
Autor:
Werner Neidhart, Volker Breu, Daniel Bur, Kaspar Burri, Martine Clozel, Georges Hirth, Marcel Müller, Hans P. Wessel, Henri Ramuz
Publikováno v:
CHIMIA, Vol 50, Iss 11 (1996)
Since its discovery, endothelin-1 has attracted considerable scientific interest for its extremely potent and long-lasting vasoconstrictor effect and its binding to G-protein-coupled receptors. The endothelins appear to be part of a functional regula
Externí odkaz:
https://doaj.org/article/ff1c28abe16f4701bf554dd2d5318630
Autor:
Walter Fischli, Hans Peter Märki, Maurice Wihelm, Marcel Muller, Christian Oefner, Michelangelo Scalone, Eric Vieira, Wolfgang Wostl, Daniel Bur, Heinz Stadler, Georges Hirth, Rolf Güller, Volker Breu, Alfred Binggeli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1397-1402
The identification, synthesis and activity of a novel class of piperidine renin inhibitors is presented. The most active compounds show activities in the picomolar range and are among the most potent renin inhibitors ever identified.
Autor:
Uwe Klinkhammer, Volker Breu, Henri Ramuz, Werner Neidhart, Kaspar Burri, Thomas Giller, Martine Clozel, Georges Hirth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2223-2228
Implementation of a pyridylcarbamoyl group and an isopropylpyridylsulfonamide substituent as key components in the scaffold of Bosentan resulted in the identification of the potent orally active endothelin receptor antagonist Ro 48-5695. It shows aff
Autor:
Kaspar F. Burri, Volker Breu, Jean-Marie Cassal, Martine Clozel, Walter Fischli, Gillian A. Gray, Georges Hirth, Bernd-Michael Löffler, Marcel Müller, Werner Neidhart, Henri Ramuz, Arnold Trzeciak
Publikováno v:
European Journal of Medicinal Chemistry. 30:385s-389s
Autor:
Thomas Giller, Kaspar Burri, Georges Hirth, Uwe Klinkhammer, Martine Clozel, Henri Prof. Dr. Ramuz, Werner Neidhart, Volker Breu
Publikováno v:
ChemInform. 28
Autor:
Heinz Stadler, Volker Breu, Alfred Binggeli, Hans Peter Märki, Marcel Muller, Georges Hirth, Manfred Kansy, Rolf Güller, Maurice Wilhelm, Francois Montavon, Walter Fischli, Christian Jenny, Christian Oefner, Wolfgang Wostl, Eric Vieira, Daniel Bur
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(10)
Piperidine renin inhibitors with heterocyclic core modifications or hydrophilic attachments show improved physical properties (lower lipophilicity, improved solubility). Tetrahydroquinoline derivative rac-30 with a molecular weight of 517 and a log D
Autor:
Fiona Grüninger, Fritz K. Winkler, Georges Hirth, Eric Vieira, Wolfgang Wostl, Arnulf Dorn, H Stadier, Marcel Muller, Allan D'Arcy, Daniel Bur, J-P. Clozel, Walter Fischli, Volker Breu, Christian Oefner, Alfred Binggeli, Robert G. Ridley, Rolf Güller, Maerki Hans-Peter, Salima Mathews, Maurice Wilhelm
Publikováno v:
Chemistrybiology. 6(3)
Background The aspartic proteinase renin catalyses the first and rate-limiting step in the conversion of angiotensinogen to the hormone angiotensin II, and therefore plays an important physiological role in the regulation of blood pressure. Numerous
Autor:
Georges Hirth, Kaspar Burri, Werner Neidhart, Marcel Muller, Walter Fischli, Henri Ramuz, Jean-Marie Cassal, Bernd-Michael Löffier, Volker Breu, Gillian A. Gray, Martine Clozel
Publikováno v:
Nature. 365(6448)
Since its discovery, endothelin-1 has attracted considerable scientific interest because of its extremely potent and long-lasting vasoconstrictor effect and its binding to G-protein-coupled receptors. Plasma concentrations of endothelin-1 are low and
Autor:
Georges Hirth, W. Walther
Publikováno v:
Helvetica Chimica Acta. 68:1863-1871
Synthesis of the (R)- and (S)-Glycerol Acetonides. Determination of the Optical Purity The optical purity of (R)-glycerol acetonide (1) and (S)-glycerol acetonide (1′) has been determined with great accuracy by gas chromatography after derivatizati
Publikováno v:
Helvetica Chimica Acta. 65:684-702
Steroselective Total Synthesis of Natural Phytol and Derivatives thereof; Use of these Compounds in the Synthesis of Natural Vitamin K1 The Li2CuCl4-catalyzed couplings of the easily accessible bifunctional C5 allylic acetates (E)-18a and (E)-18b wit