Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Georges Guillerm"'
Autor:
Shao Yang Ku, Jean-Bernard Behr, P. Lynne Howell, Kenneth A. Cornell, Patrick Yip, Georges Guillerm, Michael K. Riscoe
Publikováno v:
Journal of Biological Chemistry. 282:22195-22206
The methionine salvage pathway is ubiquitous in all organisms, but metabolic variations exist between bacteria and mammals. 5-Methylthioribose (MTR) kinase is a key enzyme in methionine salvage in bacteria and the absence of a mammalian homolog sugge
Autor:
Georges Guillerm, Jean-Bernard Behr
Publikováno v:
Tetrahedron Letters. 48:2369-2372
A short and practical procedure for the preparation of C-2 substituted polyhydroxypyrrolidines is described. The C-2 substituent is introduced by a stereoselective addition of a Grignard reagent to a 2,3,5-protected aldofuranose and the cyclization t
Publikováno v:
Journal of Medicinal Chemistry. 49:1223-1226
6'-Cyano-5',6'-didehydro-6'-deoxyhomoadenosine (E)-1, (Z)-1, and 6'-chloro-6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine (E)-2 were synthesized and tested as new mechanism-based inhibitors of AdoHcy hydrolase. Nucleoside (E)-1 was identified as a ty
Publikováno v:
European Journal of Medicinal Chemistry. 40:1255-1261
Chitin synthase is an enzyme involved in the biosynthesis of chitin, a major structural component of the cell wall of many fungi. Since chitin is absent in vertebrates, chitin synthase has been envisaged as a valuable target in the search for new ant
Publikováno v:
Letters in Drug Design & Discovery. 2:579-583
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:5803-5807
A new series of 5'-thioadenosine derivatives 1-4 were synthesized for selectively targeting (195)Cys of human AdoHcy hydrolase. Their incubation with the enzyme resulted in time- and concentration-dependent inactivation, without major modifications o
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1713-1716
We report here the design, synthesis and biological evaluation of new models of sugar analogues for chitin synthase. These UDP-GlcNAc mimetics associate a sugar-mimicking hetaryl group and uridine, linked with different pyrophosphate bioisosteres. Th
Publikováno v:
European Journal of Organic Chemistry. 2002:1256-1262
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 44:653-659
An efficient and reliable method for the preparation of bitritiated-methylthioribose from a suitably protected 5-ketoazido-ribose derivative has been developed. This compound is an essential component in the assay of the microbial enzyme methylthiori
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1483-1486
We report here the design, synthesis and antifungal evaluation of a new model of bisubstrate analogue inhibitor for glycosyltransferases. The synthetic strategy relies on the reductive amination between the aldehyde derived from an N-allylphosphono-p