Výsledky vyhledávání - "Georges F. Carle"

Akademický článek

Autophagy inactivation in osteosarcoma leads to the appearance of poor prognosis-associated factors

Autor: Olivier Camuzard, Marie Nollet, Sabine Santucci-Darmanin, Marie-Charlotte Trojani, Nadia Ben Abderrahman, Virginie Virolle, Fanny Burel-Vandenbos, Sophie Pagnotta, François Orange, Ewa Kolano-Merlin, Georges F. Carle, Valérie Pierrefite-Carle

Publikováno v: Autophagy Reports, Vol 1, Iss 1, Pp 418-437 (2022)

Osteosarcoma (OS) is a bone cancer exhibiting a 20% survival rate for metastatic patients, which motivates the development of new therapeutic options. Among the various new treatment approaches, modulation of autophagy is the subject of rising intere

Externí odkaz: https://doaj.org/article/1476262c324a468d8952a505e1a318be

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Akademický článek

Role of autophagy in osteosarcoma

Autor: Olivier Camuzard, Sabine Santucci-Darmanin, Georges F. Carle, Valérie Pierrefite-Carle

Publikováno v: Journal of Bone Oncology, Vol 16, Iss , Pp - (2019)

Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents. It is a highly aggressive tumor with a tendency to spread to the lungs, which are the most common site of metastasis. Advanced osteosarcoma patients with metastasis

Externí odkaz: https://doaj.org/article/556ae41a37ed484ebe5b5c51609b466e

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Supplementary Figures 1 - 8 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability

Autor: Baharia Mograbi, Paul Hofman, Georges F. Carle, Daniel J. Klionsky, Valérie Vouret-Craviari, Patrick Brest, Corinne Bertolotto, Sophie Barale, Michel Tauc, Isabelle Rubera, Marius Ilie, Sandy Giuliano, Florence Pedeutour, Elisabeth Corcelle–Termeau, Abderrahman Chargui, Michaël Cerezo, Amine Belaid

PDF file - 3250K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f8122c28e504742393606d04e3cf98
https://doi.org/10.1158/0008-5472.22396746

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Data from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability

Degradation of signaling proteins is one of the most powerful tumor-suppressive mechanisms by which a cell can control its own growth. Here, we identify RHOA as the molecular target by which autophagy maintains genomic stability. Specifically, inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90ad081eb95e14eb1cdf3393556521bf
https://doi.org/10.1158/0008-5472.c.6504645

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Supplementary Movie 5 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability

AVI file - 5901K, Video 5 (related to Fig. 2G) is a time-lapse recording of a mononucleate a3-/- cell that formed a tetranucleate cell after two rounds of abortive mitosis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d662babdd4bf726769eb9d7187edbb
https://doi.org/10.1158/0008-5472.22396731

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Supplementary Movie 4 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability

AVI file - 2112K, Video 4 (related to Fig. 2F) illustrates the failed abscission of a mononucleated a3-/- cell that exited mitosis as a binucleated cell after 18 attempts at cleavage furrow formation. Note that this cell developed ectopic furrows, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e590f7d0354ecb92ce2f52d1fa61a0
https://doi.org/10.1158/0008-5472.22396734.v1

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Supplementary Movie 6 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability

AVI file - 645K, Video 6 (related to Fig. 6A) is a time-lapse recording showing that the ATG5-depleted A549 cells formed numerous ectopic furrows in addition to a wider-than-normal equatorial cleavage furrow.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759fddb40fb7bc5644389d7366b0003b
https://doi.org/10.1158/0008-5472.22396728

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Supplementary Movie 3 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability

AVI file - 2696K, Video 3 (related to Fig. 2E) is a time-lapse recording of four pairs of a3-/- cells that entered mitosis synchronously, likely bridged sister cells. Pairs of cells that entered mitosis synchronously are outlined in color in the firs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82b5f3ef65e0f55a716b7b4f10aca02
https://doi.org/10.1158/0008-5472.22396737.v1

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Supplementary Movie 2 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability

AVI file - 875K, Video 2 (related to Fig. 2D) shows the delayed abscission of an a3-/- cell that remained connected by an intracellular bridge for up to 8 h 45 min before separating.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70110e40cabfe0a93f182252c69185ba
https://doi.org/10.1158/0008-5472.22396740.v1

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Autophagie et pathologies osseuses

Autor: Marie-Charlotte Trojani, Véronique Breuil, Valérie Pierrefite-Carle, Georges F. Carle, Sabine Santucci-Darmanin

Publikováno v: Revue du Rhumatisme. 89:140-144

Resume L’autophagie est un processus cellulaire ubiquitaire, permettant l’elimination et le recyclage des proteines et organelles endommagees. Au niveau basal, ce processus joue un role dans le controle qualite, participant ainsi a l’homeostasi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28cb994823c25ffe382ea6630533710a
https://doi.org/10.1016/j.rhum.2021.06.014

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