Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Georges E Janssens"'
Autor:
Rebecca L McIntyre, Eileen G Daniels, Marte Molenaars, Riekelt H Houtkooper, Georges E Janssens
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 9, Pp 1-11 (2019)
Abstract Reversing or slowing the aging process brings great promise to treat or prevent age‐related disease, and targeting the hallmarks of aging is a strategy to achieve this. Epigenetics affects several if not all of the hallmarks of aging and h
Externí odkaz:
https://doaj.org/article/2b84af9709f4463188efcfc603c9e4eb
Autor:
Yasmine J Liu, Georges E Janssens, Rebecca L McIntyre, Marte Molenaars, Rashmi Kamble, Arwen W Gao, Aldo Jongejan, Michel van Weeghel, Alyson W MacInnes, Riekelt H Houtkooper
Publikováno v:
PLoS Genetics, Vol 15, Iss 3, p e1007633 (2019)
The deregulation of metabolism is a hallmark of aging. As such, changes in the expression of metabolic genes and the profiles of amino acid levels are features associated with aging animals. We previously reported that the levels of most amino acids
Externí odkaz:
https://doaj.org/article/27b95c315ec94032878fc1ba1ca5267e
Publikováno v:
Frontiers in Aging, Vol 5 (2024)
IntroductionGeroprotection is an emerging field of research focused on devising strategies for combating the mechanisms of ageing. This study held three aims: 1) to explore the willingness to utilise five different geroprotective measures (i.e., exer
Externí odkaz:
https://doaj.org/article/37f033119a1c4c3b85eb4ca23a8239d7
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167394 (2016)
There is a large variability in lifespans of individuals even if they are genetically identical and raised under the same environmental conditions. Our recent system wide study of replicative aging in baker's yeast predicts that protein biogenesis is
Externí odkaz:
https://doaj.org/article/3358cbd051404001af7d46b3b0d07fc2
Autor:
Georges E Janssens, Anne C Meinema, Javier González, Justina C Wolters, Alexander Schmidt, Victor Guryev, Rainer Bischoff, Ernst C Wit, Liesbeth M Veenhoff, Matthias Heinemann
Publikováno v:
eLife, Vol 4 (2015)
An integrated account of the molecular changes occurring during the process of cellular aging is crucial towards understanding the underlying mechanisms. Here, using novel culturing and computational methods as well as latest analytical techniques, w
Externí odkaz:
https://doaj.org/article/b6e66abd676c4316933d6110f7a0a48f
Autor:
Weisha Li, Rebecca L. McIntyre, Bauke V. Schomakers, Rashmi Kamble, Anne H.G. Luesink, Michel van Weeghel, Riekelt H. Houtkooper, Arwen W. Gao, Georges E. Janssens
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109949- (2024)
Summary: As the global aging population rises, finding effective interventions to improve aging health is crucial. Drug repurposing, utilizing existing drugs for new purposes, presents a promising strategy for rapid implementation. We explored naltre
Externí odkaz:
https://doaj.org/article/71f17d80276646c883e60bcbc8f5ad53
Autor:
Alessandra Tammaro, Eileen G. Daniels, Iman M. Hu, Kelly C. ‘t Hart, Kim Reid, Rio P. Juni, Loes M. Butter, Goutham Vasam, Rashmi Kamble, Aldo Jongejan, Richard I. Aviv, Joris J.T.H. Roelofs, Eleonora Aronica, Reinier A. Boon, Keir J. Menzies, Riekelt H. Houtkooper, Georges E. Janssens
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108681- (2024)
Summary: Aging increases the risk of age-related diseases, imposing substantial healthcare and personal costs. Targeting fundamental aging mechanisms pharmacologically can promote healthy aging and reduce this disease susceptibility. In this work, we
Externí odkaz:
https://doaj.org/article/42cc145abf8d478f88355c37c49e69d9
Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in mice
Autor:
Kim Reid, Eileen G. Daniels, Goutham Vasam, Rashmi Kamble, Georges E. Janssens, Iman M. Hu, Alexander E. Green, Riekelt H. Houtkooper, Keir J. Menzies
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Maintaining mitochondrial function is critical to an improved healthspan and lifespan. Introducing mild stress by inhibiting mitochondrial translation invokes the mitochondrial unfolded protein response (UPRmt) and increases lifespan in seve
Externí odkaz:
https://doaj.org/article/04f22427ca1c4e4aba80208d5951efcd
Autor:
Rebecca L. McIntyre, Marte Molenaars, Bauke V. Schomakers, Arwen W. Gao, Rashmi Kamble, Aldo Jongejan, Michel van Weeghel, André B.P. van Kuilenburg, Richard Possemato, Riekelt H. Houtkooper, Georges E. Janssens
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111928- (2023)
Summary: The human population is aging, and the need for interventions to slow progression of age-related diseases (geroprotective interventions) is growing. Repurposing compounds already used clinically, usually at modified doses, allows rapid imple
Externí odkaz:
https://doaj.org/article/a500213dab204e5bbc1eb68838e73572
Publikováno v:
Ageing research reviews. 87
Age-related loss of function brings age-related disease, and therefore it is of primary importance to search for interventions that can help minimize detrimental symptoms people deal with in old age. Fungi have always been given a great deal of atten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9d8c58d0cfd0a45ef3e6571a9183e4
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