An Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study

Autor: Blandine De La Gastine, Soizic Percevault, Laurent Varin, Nicolas Richard, Fabienne Fobe, Benoît Plaud, Georges Daccache, Vincent Compere, Jean-Jacques Parienti, Antoine Coquerel, Magalie Loilier, Nathalie Bleyzac, Laurent Bourguignon, Sylvain Goutelle, Véronique Lelong-Boulouard

Publikováno v: Pharmaceutics, Vol 14, Iss 10, p 2177 (2022)

Cytochrome P450 2D6 (CYP2D6) gene polymorphisms influence the exposure to tramadol (T) and its pharmacologically active metabolite, O-demethyl tramadol (O-dT). Tramadol has been considered as a candidate probe drug for CYP2D6 phenotyping. The objecti

Externí odkaz: https://doaj.org/article/ee290fbcb63e4bc0b0972c421252562e

Tolerance and efficacy of a polyamine-deficient diet for the treatment of perioperative pain

Autor: Anissa Belbachir, Anne-Laure Sérandour, Pierre Schoeffler, Florin Dimache, Georges Daccache, Jean-Pierre Estebe, Cécile Degryse, Alain Le Naoures, Gilles Rezzadori

Publikováno v: Nutrition
Nutrition, 2016, In press. ⟨10.1016/j.nut.2016.02.018⟩
Nutrition, Elsevier, 2016, In press. ⟨10.1016/j.nut.2016.02.018⟩
Nutrition, Elsevier, 2016, In press. 〈10.1016/j.nut.2016.02.018〉

Background Polyamines have been identified as pain agonists and interact with N-methyl-D-aspartate receptors. A prospective, randomized, multicenter, and blinded phase II clinical trial was conducted to evaluate a polyamine-deficient diet for the tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e6888a52806fadfdc6da62cad37463
https://univ-rennes.hal.science/hal-01290418

Relation between aortic dicrotic notch pressure and mean aortic pressure in adults

Autor: Jean-Louis He´bert, Denis Chemla, Nicole Wuilliez, Georges Daccache, Yves Lecarpentier, Liliane Larsonneur, Catherine Coirault, Karen Zamani

Publikováno v: The American journal of cardiology. 76(4)

It has recently been suggested that mean arterial pressure provides a reliable estimate of dicrotic notch pressure in infants and children. The aim of the present study was twofold: (1) to investigate the relation existing between aortic dicrotic not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6c1655fd4e0f5eb39af8817d58b2b7
https://pubmed.ncbi.nlm.nih.gov/7618629