Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Georges C. Frech"'
Autor:
Jorja Degrado-Warren, Max Dufford, Jian Chen, Paul L. Bartel, Donna Shattuck, Georges C. Frech
Publikováno v:
BioTechniques, Vol 44, Iss 2, Pp 265-273 (2008)
The nuclear yeast two-hybrid (Y2H) system is the most widely used technology for detecting interactions between proteins. A common approach is to screen specific test proteins (baits) against large compilations of randomly cloned proteins (prey libra
Externí odkaz:
https://doaj.org/article/ff7f9fe233044edfa7a354d6474457ea
Autor:
Georges C. Frech, Deborah Trem, Ted D. Adams, David A. Frank, Victor Abkevich, Kirsten Timms, Gongping He, Robyn Riley, Srikanth Jammulapati, Steven C. Hunt, Donna Shattuck, Deanna L. Russell, Jerry S. Lanchbury, Richard E. Gress, Mark H. Skolnick, Chris Neff, Thanh Tran, Diana Iliev, Alexander Gutin, Steven Stone
Publikováno v:
Human Molecular Genetics. 15:2709-2720
The molecular etiology of obesity predisposition is largely unknown. Here, we present evidence that genetic variation in TBC1D1 confers risk for severe obesity in females. We identified a coding variant (R125W) in TBC1D1 that segregated with the dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a298fac8dc76b060f2aa3617cc6e00e6
https://doi.org/10.1093/hmg/ddl204
https://doi.org/10.1093/hmg/ddl204
Autor:
H. Mark Skolnick, D. Ted Adams, Thanh Tran, Srikanth Jammulapati, Charles H. Hensel, Brian T. Bloomquist, Steven C. Hunt, Richard E. Gress, Robyn Riley, Drew Gibbs, Chris Neff, Victor Abkevich, Alexander Gutin, Donna Shattuck, Jennifer Potter, Deanna L. Russell, M.M. Peter Rae, David Sexton, Steven Stone, Georges C. Frech, Diana Iliev, John Amatruda
Publikováno v:
The American Journal of Human Genetics. 70:1459-1468
Although the predisposition to morbid obesity is heritable, the identities of the disease-causing genes are largely unknown. Therefore, we have conducted a genomewide search with 628 markers, using multigenerational Utah pedigrees to identify genes i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc16dede4755443cc82bdb608cfc36cc
https://doi.org/10.1086/340670
https://doi.org/10.1086/340670
Autor:
Larry Simpson, Christoph W. Turck, Georges C. Frech, Frédéric Bringaud, E M Byrne, Renata Stripecke, S Freedland
Publikováno v:
Molecular and Cellular Biology. 17:3915-3923
To identify specific proteins interacting with guide RNAs (gRNAs) in mitochondrial ribonucleoprotein complexes from Leishmania tarentolae, fractionated and unfractionated mitochondrial extracts were subjected to UV cross-linking with added labeled gR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a86934e602e16d5be52e01bc35d0f063
https://doi.org/10.1128/mcb.17.7.3915
https://doi.org/10.1128/mcb.17.7.3915
Autor:
Georges C. Frech, Joanna Liliental, Agda M. Simpson, Marian Peris, Jeremy Grunstein, Larry Simpson
Publikováno v:
Molecular and Biochemical Parasitology. 85:9-24
Two polypeptides of 50 and 45 kDa were adenylated by incubation of a mitochondrial extract from Leishmania tarentolae with [alpha-32P]ATP. These proteins were components of a complex that sedimented at 20S in glycerol gradients and migrated as a sing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29164439934475272068c59e3268f92
https://doi.org/10.1016/s0166-6851(96)02795-8
https://doi.org/10.1016/s0166-6851(96)02795-8
Autor:
Georges C. Frech, Larry Simpson
Publikováno v:
Molecular and Cellular Biology. 16:4584-4589
An RNA editing-like internal uridine (U) incorporation activity (G. C. Frech, N. Bakalara, L Simpson, and A. M. Simpson, EMBO J. 14:178-187, 1995) and a 3'-terminal U addition activity (N. Bakalara, A. M. Simpson, and L. Simpson, J. Biol. Chem. 264:1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfbace99e5ce64730a404943a2ca6ae
https://doi.org/10.1128/mcb.16.8.4584
https://doi.org/10.1128/mcb.16.8.4584
Autor:
Benjamin Groves, Georges C Frech, Charles Owen, Edward Ager, Christopher Pasko, Larry Rea, Maylene Corpuz, Brian Hicke, Nathan A. Ledeboer, Gerald A. Denys, Wendy Smith, Wes Lindsey, Robert D. Jenison, Ashley Warcup, Denton Munns
Clostridium difficile can carry a genetically variable pathogenicity locus (PaLoc), which encodes clostridial toxins A and B. In hospitals and in the community at large, this organism is increasingly identified as a pathogen. To develop a diagnostic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96173438acf6d2ec6e048177a168e309
https://europepmc.org/articles/PMC3421499/
https://europepmc.org/articles/PMC3421499/
Publikováno v:
BMC Research Notes, Vol 5, Iss 1, p 430 (2012)
BMC Research Notes
BMC Research Notes
Background The bacterium Staphylococcus aureus constitutes one of the most important causes of nosocomial infections. One out of every three individuals naturally carries S. aureus in their anterior nares, and nasal carriage is associated with a sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133faa157fee933f65f59acea83dd8bc
http://www.biomedcentral.com/1756-0500/5/430
http://www.biomedcentral.com/1756-0500/5/430
Publikováno v:
Proceedings of the National Academy of Sciences. 87:9514-9518
Thyrotropin-releasing hormone (TRH) is an important extracellular regulatory molecule that functions as a releasing factor in the anterior pituitary gland and as a neurotransmitter/neuromodulator in the central and peripheral nervous systems. Binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1241af4e97c14603e7bac6ffd989fe
https://doi.org/10.1073/pnas.87.24.9514
https://doi.org/10.1073/pnas.87.24.9514
Autor:
Jane Weaver-Feldhaus, Srikanth Jammulapati, Donna Shattuck, Alun Thomas, Charles H. Hensel, Robyn Riley, Richard E. Gress, Victor Abkevich, Alexander Gutin, Deanna L. Russell, Tess Macalma, Mike Francis, Steven C. Hunt, Xiankang Hong, Maria Matthews Richards, Chris Neff, Steven Stone, Ted D. Adams, Thanh Tran, Georges C. Frech
Publikováno v:
Human genetics. 109(3)
Several linkage studies have hinted at the existence of an obesity predisposition locus on chromosome 20, but none of these studies has produced conclusive results. Therefore, we analyzed 48 genetic markers on chromosome 20 for linkage to severe obes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d65d4e7562152eab81359654bc5b9679
https://pubmed.ncbi.nlm.nih.gov/11702208
https://pubmed.ncbi.nlm.nih.gov/11702208