Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Georges Blattner"'
Autor:
Rajeev Rai, Marianna Romito, Elizabeth Rivers, Giandomenico Turchiano, Georges Blattner, Winston Vetharoy, Dariusz Ladon, Geoffroy Andrieux, Fang Zhang, Marta Zinicola, Diego Leon-Rico, Giorgia Santilli, Adrian J. Thrasher, Alessia Cavazza
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
In recent years, hematopoietic stem cells gene editing has emerged as a promising tool to treat blood disorders. Here the authors develop a CRISPR/Cas9-based genome editing strategy that allows the precise correction of Wiskott-Aldrich Syndrome in vi
Externí odkaz:
https://doaj.org/article/e93094c9c51f4c1aa746e611fd6ea64c
Publikováno v:
Frontiers in Genome Editing, Vol 2 (2020)
Gene editing technologies show great promise for application to human disease as a result of rapid developments in targeting tools notably based on ZFN, TALEN, and CRISPR-Cas systems. Precise modification of a DNA sequence is now possible in mature h
Externí odkaz:
https://doaj.org/article/2fcd0dcb4ee442fda5ffcae7a7d8ada3
Autor:
Thorsten Mosler, H Irem Baymaz, Justus F Gräf, Ivan Mikicic, Georges Blattner, Edward Bartlett, Matthias Ostermaier, Rossana Piccinno, Jiwen Yang, Andrea Voigt, Marco Gatti, Stefania Pellegrino, Matthias Altmeyer, Katja Luck, Ivan Ahel, Vassilis Roukos, Petra Beli
PARP1 mediates poly-ADP-ribosylation of proteins on chromatin in response to different types of DNA lesions. PARP inhibitors are used for the treatment of BRCA1/2-deficient breast, ovarian, and prostate cancer. Loss of DNA replication fork protection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab05c84687dfd823747403cbec6cf62
https://www.zora.uzh.ch/id/eprint/229089/
https://www.zora.uzh.ch/id/eprint/229089/
Autor:
Georges Blattner, Fang Zhang, Winston Vetharoy, Marianna Romito, Adrian J. Thrasher, Elizabeth Rivers, Dariusz Ladon, Marta Zinicola, Diego Leon-Rico, Rajeev Rai, Giandomenico Turchiano, Giorgia Santilli, Geoffroy Andrieux, Alessia Cavazza
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Wiskott-Aldrich syndrome (WAS) is an X-linked primary immunodeficiency with severe platelet abnormalities and complex immunodeficiency. Although clinical gene therapy approaches using lentiviral vectors have produced encouraging results, full immune
Autor:
Valentina Pennucci, Julia Klermund, Giandomenico Turchiano, Claudio Mussolino, Sushmita Poddar, Toni Cathomen, Melanie Boerries, Tatjana I. Cornu, Melina el Gaz, Georges Blattner, Geoffroy Andrieux, Gianni Monaco
Publikováno v:
Cell stem cell. 28(6)
Genome editing has shown great promise for clinical translation but also revealed the risk of genotoxicity caused by off-target effects of programmable nucleases. Here we describe chromosomal aberrations analysis by single targeted linker-mediated PC
Autor:
Melanie Boerries, Tatjana I. Cornu, Julia Klermund, Sushmita Poddar, Giandomenico Turchiano, Gianni Monaco, Toni Cathomen, Geoffroy Andrieux, Georges Blattner, Valentina Pennucci, Claudio Mussolino
Publikováno v:
SSRN Electronic Journal.
Genome editing with programmable nucleases has shown great promise for clinical translation but also revealed the risk of genotoxicity caused by chromosomal translocations or the insertion of mutations at off-target sites. Here, we describe CAST-Seq,